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MORE ABOUT THIS BOOK
Main description:
Alzheimer's disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental and computational level. The interplay of disease mechanisms and homeostatic networks will underlie the time of onset and rate of progression of the disease.
This book addresses such an integrated approach to AD. It aims to present Systems Biology, including both experimental and computational approaches, as a new strategy for the study of AD and other multifactorial diseases, with the hope that the results will translate into more effective diagnosis and treatment, as well as improved public health policies.
Written for the highly successful Methods in Molecular Biology series, practical and cutting-edge, Systems Biology of Alzheimer's Disease is intended for post-graduate students, post-doctoral researchers and experts in different fields with an interest in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases (including other neurodegenerative diseases and cancers). This book aims to complement other excellent volumes and monographs on AD that cover fundamental, physiological or medical aspects of the disease.
Contents:
Part I: Systems Biology of Multifactorial Diseases: Alzheimer's Disease
1. Alzheimer's as a Systems-Level Disease Involving the Interplay of Multiple Cellular Networks
Juan I. Castrillo and Stephen G. Oliver
2. Application of Systems Theory in Longitudinal Studies on the Origin and Progression of Alzheimer's Disease
Simone Lista, Zaven S. Khachaturian, Dan Rujescu, Francesco Garaci, Bruno Dubois, and Harald Hampel
Part II: Alzheimer's Disease: Main Underlying Pathways and Networks
3. The APP Proteolytic System and Its Interactions with Dynamic Networks in Alzheimer's Disease
Sally Hunter, Steven Martin, and Carol Brayne
4. Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing
Jiangli Tan, Qiao-Xin Li, and Genevieve Evin
5. Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models
Ana Garcia-Osta and Mar Cuadrado-Tejedor
6. Advanced Optical Super-Resolution Method and Techniques for the Study of -Amyloid Aggregation In Vitro and In Vivo
Dorothea Pinotsi, Gabriele S. Kaminski Schierle, and Clemens F. Kaminski
7. Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease
Alberto Rabano, Raquel Cuadros, Paula Merino
-Serrais, Izaskun Rodal, Ruth Benavides-Piccione, Elena Gomez, Miguel Medina, Javier DeFelipe, and Jesus Avila
8. LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells
Anne Streeter, Fiona M. Menzies, and David C. Rubinsztein
9. Advanced Mitochondrial Respiration Assay for Evaluation of Mitochondrial Dysfunction in Alzheimer's Disease
Amandine Grimm, Karen Schmitt, and Anne Eckert
10. Analysis of Microglial Proliferation in Alzheimer's Disease
Diego Gomez-Nicola and V. Hugh Perry
Part III: Comprehensive Disease Models Recapitulating Alzheimer's Disease Features: From Cellular Models to Human
11. Yeast as a Model for Alzheimer's Disease: Latest Studies and Advanced Strategies
Mathias Verduyckt, Helene Vignaud, Tine Bynens, Jeff Van den Brande, Vanessa Franssens, Christophe Cullin, and Joris Winderickx
12. Yeast as a Model for Studies on A Aggregation Toxicity in Alzheimer's Disease, Autophagic Responses, and Drug Screening
Afsaneh Porzoor and Ian Macreadie
13. Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease
Jung Yeon Lim, Stanislav Ott, and Damian C. Crowther
14. Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models
Mar Cuadrado-Tejedor and Ana Garcia-Osta
15. Gene Expression Studies on Human Trisomy 21 iPSCs and Neurons: Towards Mechanisms Underlying Down's Syndrome and Early Alzheimer's Disease-Like Pathologies
Jason P. Weick, Huining Kang, George F. Bonadurer III, and Anita Bhattacharyya
16. Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer's Disease
Nathalie G. Saurat, Frederick J. Livesey, and Steven Moore
Part IV: Experimental Systems Biology: Next Generation Molecular and High-Throughput Methods for the Study of Disease Susceptibility and Networks Dynamics Interplay in Complex Diseases
17. Next Generation Sequencing in Alzheimer's Disease
Lars Bertram
18. Pooled-DNA Sequencing for Elucidating New Genomic Risk Factors, Rare Variants Underlying Alzheimer's Disease
Sheng Chih Jin, Bruno A. Benitez, Yuetiva Deming, and Carlos Cruchaga
19. New Genome-Wide Methods for Elucidation of Candidate Copy Number Variations (CNVs) Contributing to Alzheimer's Disease Heritability
Kinga Szigeti
20. RNA-Sequencing to Elucidate Early Patterns of Dysregulation Underlying the Onset of Alzheimer's Disease
Bei Jun Chen, James D. Mills, Caroline Janitz, and Michael Janitz
21. Systems Biology Approaches to the Study of Biological Networ
ks Underlying Alzheimer's Disease: Role of miRNAs
Wera Roth, David Hecker, and Eugenio Fava
22. The Emerging Role of Metalloproteomics in Alzheimer's Disease Research
Dominic J. Hare, Alan Rembach, and Blaine R. Roberts
23. Redox Proteomics in Human Biofluids: Sample Preparation, Separation and Immunochemical Tagging for Analysis of Protein Oxidation
Fabio Di Domenico, Marzia Perluigi, and D. Allan Butterfield
24. Advanced Shotgun Lipidomics for Characterization of Altered Lipid Patterns in Neurodegenerative Diseases and Brain Injury
Miao Wang and Xianlin Han
25. AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer's Disease Pathogenesis
Soichi Ogishima, Satoru Mizuno, Masataka Kikuchi, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka, and Jun Nakaya
Part V: Computational Systems Biology, Network biology: Next Generation Computational and Integrative Network Biology Approaches for the Study of Modules, Network Dynamics, and Their Interplay in Complex Diseases
26. A Computational Network Biology Approach to Uncover Novel Genes Related to Alzheimer's Disease
Andreas Zanzoni
27. Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans
Justin Yerbury, Dan Bean, and Giorgio Favrin
28. Characterization of Genetic Networks Associated with Alzheimer's Disease
Bin Zhang, Linh Tran, Valur Emilsson, and Jun Zhu
29. Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer's Disease
Masataka Kikuchi, Soichi Ogishima, Akinori Miyashita, Ryozo Kuwano, Jun Nakaya, and Hiroshi Tanaka
30. The SDREM Method for Reconstructing Signaling and Regulatory Response Networks: Applications for Studying Disease Progression
Anthony Gitter and Ziv Bar-Joseph
Part VI: Systems Biology of Alzheimer's Disease in Practice: From Systems Biology to Early Diagnostics and Systems Medicine
31. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer's Disease
Jorge Sepulcre and Joseph C. Masdeu
32. Plasma Proteomics Biomarkers in Alzheimer's Disease: Latest Advances and Challenges
Robert Perneczky and Liang-Hao Guo
33. A Practical Guide For Exploring Opportunities of Repurposing Drugs for CNS Diseases in Systems Biology
Hongkang Mei, Gang Feng, Jason Zhu, Simon Lin, Yang Qiu, Yue Wang, and Tian Xia
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2015
Pages: 520
Weight: 652g
Availability: Available
Subcategories: Neuroscience, Psychiatry
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