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Cardiovascular Genomics
Methods and Protocols
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Main description:

As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.


Contents:

1. Modes of Defining Atherosclerosis in Mouse Models: Relative Merits and Evolving Standards
Alan Daugherty, Hong Lu, Deborah A. Howatt, and Debra L. Rateri

2. Evaluating Micro- and Macro-Vascular Disease, the End Stage of Atherosclerosis, in Rat Models
James C. Russell

3. Non-Invasive Blood Pressure Measurement in Mice
Minjie Feng and Keith DiPetrillo

4. Direct Blood Pressure Monitoring in Laboratory Rodents via Implantable Radio Telemetry
Daniel A. Huetteman and Heather Bogie

5. Measuring Kidney Function in Conscious Mice

David L. Mattson

6. Ischemic Stroke in Mice and Rats
Aysan Durukan and Turgut Tatlisumak

7. Mouse Surgical Models in Cardiovascular Research
Oleg Tarnavski

8. Echocardiographic Examination in Rats and Mice
Jing Liu and Dean F. Rigel

9. QTL Mapping in Intercross and Backcross Populations
Fei Zou

10. Quantitative Trait Locus Analysis Using J/qtl
Randy Smith, Keith Sheppard, Keith DiPetrillo, and Gary Churchill

11. Computing Genetic Imprinting Expressed by Haplotypes
Yun Cheng, Arthur Berg, Song Wu, Yao Li, and Rongling Wu

12. Haplotype Association Mapping in Mice
Shirng-Wern Tsaih and Ron Korstanje

13. Candidate Gene Association Analysis
Jonathan B. Singer

14. Genome-Wide Association Study in Humans
J. Gustav Smith and Christopher Newton-Cheh

15. Bioinformatics Analysis of Microarray Data
Yunyu Zhang, Joseph Szustakowski, and Martina Schinke

16. eQTL Analysis in Mice and Rats
Bruno M. Tesson and Ritsert C. Jansen

17. eQTL Analysis in Humans
Lude Franke and Ritsert C. Jansen

18. A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation
Paul Fisher, Harry Noyes, Stephen Kemp, Robert Stevens, and Andrew Brass


PRODUCT DETAILS

ISBN-13: 9781617796432
Publisher: Springer (Humana Press Inc.)
Publication date: March, 2012
Pages: 360
Weight: 759g
Availability: Available
Subcategories: Cardiovascular Medicine, Genetics
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