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MORE ABOUT THIS BOOK
Main description:
According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.
Contents:
Part I. Crossroads of Inflammation and Cancer: Molecular Aspects
Chapter 1. Immunohistochemical Analysis of 8-nitroguanine, a Nitrative DNA Lesion, in Relation to Inflammation-Associated Carcinogenesis
Yusuke Hiraku and Shosuke Kawanishi
Chapter 2. Molecular Analysis of Genetic Instability Caused by Chronic Inflammation
Bin Yan, Yuanlin Peng, and Chuan-Yuan Li
Chapter 3. Obesity Provides a Permissive Milieu in Inflammation-Associated Carcinogenesis: Analysis of Insulin and IGF Pathways
Nomeli P. Nunez, Stephen D. Hursting, Shoshana Yakar, Dan Fowler, and Charles Vinson
Chapter 4. Detecting and Modulating the NF-kB Activity in Human Immune Cells: Generation of Human Cell Lines with Altered Levels of NF-kB
Fui G. Goh, Helen Banks, and Irina A. Udalova
Chapter 5. Inflammation-Related Aberrant Patterns of DNA Methylation: Detection and Role in Epigenetic Deregulation of Cancer Cell Transcriptome
Hiromu Suzuki, Minoru Toyota, Yutaka Kondo, and Yasuhisa Shinomura
Chapter 6. cDNA Microarray Analysis of Inflammatory Breast Cancer Signatures
Steven J. Van Laere, Peter B. Vermeulen, and Luc Y. Dirix
Chapter 7. Analysis of the TLR/NF-kB Pathway in Antigen-Presenting Cells in Malignancies Promoted by Inflammation
J. Magarian Blander
Chapter 8. Induced Nitric Oxide Synthase (iNOS) as a Major Player in the Oncogenic Transformation of Inflamed Tissue
Guang-Yu Yang, Sofia Taboada, and Jie Liao
Part II. Molecular and Cellular Approaches to Diagnostics and Drug Target Discovery in Inflammation-Related Oncogenesis
Chapter 9. Development of a Cell-Based Assay to Quantify the Inflammatory Potential of Test Substances and Screen Compound Libraries for Anti-Cancer Drug Candidates in a High-Throughput Format
Serguei V. Kozlov
Chapter 10. The NF-kB Transcription Factor Pathway as a Therapeutic Target in Cancer: Methods for Detection of NF-kB Activity
Claudio Mauro, Francesca Zazzeroni, Salvatore Papa, Concetta Bubici, and Guido Franzoso
Chapter 11. Inhibiting Pro-Inflammatory NF-kB Signaling Using Cell-Penetrating NEMO Binding Domain (NBD) Peptides
Lisa A. Madge and Michael J. May
Chapter 12. Quantitative Measurement of Cytokine Expression in Synoviocytes Derived from Rheumatoid Arthritis Patients
Scott Thomson and Irina A. Udalova
Chapter 13. Molecular Characterization of Inflammation-Induced JNK/c-Jun Signaling Pathway in Connection with Tumorigenesis
Bozena Kaminska
Chapter 14. Molecular Characterization of STAT Signaling in Inflammation and Tumorigenesis
Alicja Adach, Aleksandra Ellert-Miklaszewska, and Bozena Kaminska
Chapter 15. Inflammation and Tumor Progression: A Lesson from TNF-a-Dependent FAK Signaling in Cholangiocarcinoma
Naing Naing Mon, Toshio Kokuryo, and Michinari Hamaguchi
Chapter 16. Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPARd -> 14-3-3e Pathway
Kenneth K. Wu and Jun-Yang Liou
Chapter 17. PPARb/d Agonist Increases the Expression of PGE2 Receptor Subtype EP4 in Human Lung Carcinoma Cells
Jeffrey D. Ritzenthaler, Jesse Roman, and ShouWei Han
Chapter 18. Investigating Macrophage and Malignant Cell Interactions In vitro
Thorsten Hagemann and Toby Lawrence
Chapter 19. Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anti-Cancer Therapy
Pierre Smirnov
Chapter 20. Application of Phage Display to Discovery of Tumor-Specific Homing Peptides: Developing Strategies for Therapy and Molecular Imaging of Canc
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 424
Weight: 1030g
Availability: Available
Subcategories: General Issues, Oncology
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