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Main description:
The immune system is a complex network in which different cell types and soluble factors interact to efficiently eliminate various kinds of microorganisms as well as aberrant cell clones. The roots of immunologic investigations reach far into the past. In 430 BC, Thucydides reported that survivors of the plague did not present a second time with similar symptoms. The first report of a successful immu- therapy was made by Edward Jenner in 1798 who found a protective effect of cowpox vaccination against human pox. Since then, much knowledge has been accumulated; today, investigations of the molecular mechanisms of immune regulation are of central research interest. The novel insights into gene polymorphisms and gene regulation gathered from this work has improved our knowledge of individual immune reactions and risk factors in overcoming infections. Strategies to use the immune system for cancer treatment have been propelled by the discovery of divergent immunoregulatory cytokines and the introduction of new gene therapy strategies to modify immune responses. Recently, the discovery of various dendritic cells has focused attention on these cell types as central elements of the immune response and to the possibility of dendritic cell expansion, maturation, and consecutive stimulation with immuno- active tumor-specific peptides. Similarly, methods for ex vivo expansion of various stem cell-derived cell types have led to an improved therapeutic management of various benign and malignant diseases.
Contents:
Part I. Introduction
Primary Immunodeficiencies Caused by Defects of Cytokines and Cytokine Receptors
Volker Wahn
Part II. Detection Assays for Cytokines and Growth Factors
Intracellular Detection of T-Cell Cytokines: Differentiation of TH1 and TH2 Cells
Ursula Banning and Dieter Koerholz
Analysis of Cytokine Profiles in Human Skin
Jean Krutmann, Renz Mang, and Susanne Grether-Beck
Intracytoplasmic Detection of Proinflammatory Cytokines and Chemokines in Monocytes by Flow Cytometry
Christian Schultz
Flow-Cytometric Immune Function Methodology for Human Peripheral Blood Dendritic Cells
Kerstin Willmann
Evaluation of the Frequency of Virus-Specific CD8+ T Cells by Cytokine Flow Cytometry
Bodo Hoffmeister, Felix Kiecker, Ingolf Surel, Elham Khatamzas, Volker Schuster, Hans-Dieter Volk, and Florian Kern
Detection of Common Cytokine and Colony Stimulating Factor Gene Polymorphisms
Thomas Lehrnbecher and Stephen J. Chanock
Apoptosis Induction by TRAIL
Angelika Eggert, Hauke Sieverts, and Henning Walczak
Angiogenic Cytokines: Quantitative and Functional Analysis
Angelika Eggert and John H. Maris
Part III. Protocols on Gene Therapy
Experimental Strategies for Combined Suicide and Immune Cancer Gene Therapy: An Overview
Christof M. Kramm, Tim Niehues, and Nikolai G. Rainov
Gene Therapy with Plasmids Encoding Cytokine- or Cytokine Receptor-IgG Chimeric Proteins
Ciriaco A. Piccirillo and Gerald J. Prud'homme
Interferon-b Gene Therapy for the Treatment of Arthritis
Yuti Chernajovsky, Hanna Dreja, Kostas Triantaphyllopoulos, and David Gould
Gene Gun-Based In Vivo Gene Transfer: Application to DNA Vaccination
Tohru Sakai and Kunisuke Himeno
Purification of the Eukaryotic Heat-Shock Proteins Hsp70 and gp96
Arne von Bonin, Solveig H.More, and Minka Breloer
Genetic Engineering of a Recombinant Fusion Protein Possessing an Antitumor Antibody Fragment and a TNF-a Moiety
Jim Xiang and John R. Gordon
Genetic Engineering of Dendritic Cells by Adenovirus-Mediated TNF-a Gene Transfer
Jim Xiang and Josh Wu
Retroviral Transfer of T-Cell Receptor Genes into Human Peripheral Blood Lymphocytes
Timothy M. Clay and Michael I. Nishimura
Gene Transfer to Articular Chondrocytes with Recombinant Adenovirus
Glyn D. Palmer, Elvire Gouze, Jean-Noel Gouze, Oliver B. Betz, Christopher H. Evans, and Steven C. Ghivizzani
Gene Therapy of X-Linked Severe Combined Immunodeficiency
Salima Hacein-Bey-Abina, Genevieve de Saint Basile, and Marina Cavazzana-Calvo
Gene Transfer for Generation of Tumor and Leukemia Vaccines
Dagmar Dilloo and Andree Zibert
Cytokine Gene Delivery into the Central Nervous System Using Intrathecally Injected Nonreplicative Viral Vectors
Roberto Furlan, Stefano Pluchino, Peggy C. Marconi, and Gianvito Martino
Part IV. Ex Vivo Cell Expansion
In Vitro Regulation of Colony Stimulating Factor-Mediated Hematopoiesis in Healthy Individuals and Patients with Different Types of Myeloproliferative Disease
Thomas Vraetz, Peter D. Emanuel, and Charlotte M. Niemeyer
In Vitro Generation of Dendritic Cells from Cord Blood CD34+ Hematopoietic Progenitors Cells
Bruno Canque, Michele Rosenzwajg, and Jean Claude Gluckman
Generation of Transgenic T Cells from Human CD34+ Cord Blood Cells
Bruno Verhasselt, Evelien Naessens, and Veronique Stove
Ex Vivo Expansion of Umbilical Cord Blood Cells on Feeder Layers
Martin Bornhauser
Ex Vivo Production of Cord Blood CD34+ Derived Myeloid Precursors After Serum-Free Static Culture
Sergio Querol
Ex Vivo Expansion of Hematopoietic Stem Cells
Beatriz Albella, Jose
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 496
Weight: 723g
Availability: Available
Subcategories: Immunology
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