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MORE ABOUT THIS BOOK
Main description:
Chemogenomics aims toward the systematic identification of small molecules that interact with the products of the genome and modulate their biological function. The establishment, analysis, prediction, and expansion of a comprehensive ligand-target SAR (structure-activity relationship) matrix has followed the elucidation of the human genome and presents a key scientific challenge for the twenty-first century. The anno- tion and knowledge-based exploration of the ligand-target SAR matrix is then expected to impact science greatly. Progress alongside this challenge without a doubt will c- tribute to further the fundamental understanding of the biological function of the individual proteins and ultimately provide a basis for the discovery of new and better therapies for diseases. While historically the chemogenomics approach is based on efforts that systematically explore target gene families, today broader in vitro and in silico approaches are available to encompass wider genomes. In this book, experts from academia and industry outline relevant aspects of ch- istry, biology, and molecular informatics which are the cornerstones of chemogenomics. General introductory chapters are combined with chapters describing methods and pro- cols, which are the gold standard of the Methods in Molecular Biology book series.
Contents:
1. Organizing Bioactive Compound Discovery in Target Families
H. Peter Nestler
2. Compound Library Design for Target Families
K. V. Balakin, Y. A. Ivanenkov, and N. P. Savchuk
3. Targeting the Purinome
Jeremy M. Murray and Dirksen E. Bussiere
4. Cofactor Chemogenomics
Ratna Singh and Andrea Mozzarelli
5. Chemogenomics with Protein Secondary Structure Mimetics
Garland R. Marshall, Daniel J. Kuster, and Ye Che
6. Database Systems for Knowledge-Based Discovery
Sarma A.R.P. Jagarlapudi and Radha Kishan K.V.
7. Knowledge-Based Virtual Screening: Application to the MDM4/p53 Protein-Protein Interaction
Edgar Jacoby, Andreas Boettcher, Lorenz M. Mayr, Nathan Brown, Jeremy L. Jenkins, Joerg Kallen, Caroline Engeloch, Ulrich Schopfer, Pascal Furet, Keiichi Masuya, and Joanna Lisztwan
8. Off-Target Networks Derived from Ligand Set Similarity
Michael J. Keiser and Jerome Hert
9. Chemogenomic Analysis of Safety Profiling Data
Josef Scheiber and Jeremy L. Jenkins
10. Network and Pathway Analysis of Compound-Protein Interactions
Richard J. Brennan and Svetlana Bureeva
11. The Flexible Pocketome Engine for Structural Chemogenomics
Ruben Abagyan and Irina Kufareva
12. Structure-Based Chemogenomics: Analysis of Protein Family Landscapes
Bernard Pirard
13. Hypothesis-Driven Screening
Ulrich Schopfer, Caroline Engeloch, Frank Hoehn, Herve Mees, Jennifer Leeds, Fraser Glickman, Gunther Scheel, Sandrine Ferrand, Peter Fekkes, and Martin Pfeifer
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: March, 2012
Pages: 330
Weight: 702g
Availability: Available
Subcategories: Biochemistry, Genetics
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