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Main description:
Covering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development , Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the "root" of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and easily accessible, Pharmacogenomics in Drug Discovery and Development, Second Edition seeks to serve both professionals and novices with comprehensive resources and a holistic view for the translation of pharmacogenomics into better preventive and personalized medical care.
Contents:
Part I. Systems and "Omics" Studies in Pharmacogenomics
1. From Pharmacogenomics and Systems Biology to Personalized Care: A Framework of Systems and Dynamical Medicine
Qing Yan
2. Translational Bioinformatics Approaches for Systems and Dynamical Medicine
Qing Yan
3. Whole Blood Transcriptomic Analysis to Identify Clinical Biomarkers of Drug Response
Grant P. Parnell and David R. Booth
4. Diagnostic Procedures for Paraffin Embedded Tissues Analysis in Pharmacogenomic Studies
Raffaele Palmirotta, Maria Laura De Marchis, Giorgia Ludovici, Patrizia Ferroni, Pasquale Abete, Fiorella Guadagni, and David Della-Morte
5. Approach to Clinical and Genetic Characterization of Statin-Induced Myopathy
QiPing Feng
6. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches
Tristan M. Sissung, Andrew K.L. Goey, Ariel M. Ley, Jonathan D. Strope, and William D. Figg
7. G Protein-Coupled Receptor Accessory Proteins and Signaling: Pharmacogenomic Insights
Miles D. Thompson, David E. C. Cole, Pedro A. Jose, and Peter Chidiac
8. G Protein-Coupled Receptor Mutations and Human Genetic Disease
Miles D. Thompson, Geoffrey N. Hendy, Maire E. Percy, Daniel G. Bichet and David E. C. Cole
9. Pharmacogenetics of the G Protein-Coupled Receptors
Miles D. Thompson, David E. Cole, Valerie Capra, G. Enrico Rovati, and Brinda K. Rana
Part II. Clinical Applications of Pharmacogenomics
10. Pharmacogenomics of Heart Failure
Anastasios Lymperopoulos and Faren French
11. Pharmacogenomics in the Development and Characterization of Atheroprotective Drugs
Efi Valanti, Alexandros Tsompanidis, and Despina Sanoudou
12. Management of Side-Effects in the Personalized Medicine Era: Chemotherapy Induced Peripheral Neuropathy
P. Alberti and G. Cavaletti
13. Pharmacogenomics of Alzheimer's Disease: Novel Therapeutic Strategies for Drug Development
Ramon Cacabelos, Pablo Cacabelos, Clara Torrellas, Sergio Pineiro-Hermida, Maria J. Villanueva-Millan, Cristina Solveira, Ivan Tellado, and Juan C. Carril
14. Pharmacogenetics of Antipsychotic Treatment in Schizophrenia
Jennie G. Pouget and Daniel J. Muller
15. Pharmacogenetics of Addiction Therapy
David A. Nielsen, Ellen M. Nielsen, Teja Dasari, and Catherine J. Spellicy
16. Pharmacogenetics in Rheumatoid Arthritis
Deepali Sen, Jisna R Paul, and Prabha Ranganathan
17. The Pharmacogenomics of Osteoporotic Fractures
Jose A. Riancho and Flor Perez-Campo
18. Pharmacogenomics and Pharmacoepigenomics in Pediatric Medicine
Barkur S. Shastry
19. Pharmacogenomics in Children
Michael Rieder
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2014
Pages: 735
Weight: 652g
Availability: Available
Subcategories: Pharmacology
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