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MORE ABOUT THIS BOOK
Main description:
Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular Biology (TM) series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases.
Contents:
Macromolecular Drug Delivery
Dr. Mattias Belting, ed.
Table of Contents
Preface
Contributors
Developments in Macromolecular Drug Delivery; Review Chapter
Mattias Belting and Anders Wittrup
Synthetic vs. Natural/Biodegradable Polymers for Delivery of shRNA Based Cancer Therapies; Review chapter
John S. Vorhies and John J. Nemunaitis
siRNA and DNA Transfer to Cultured Cells
Bagavathi Gopalakrishnan and Jon Wolff
Poly(ss-amino esters): Procedures for Synthesis and Gene Delivery
Jordan J. Green, Gregory T. Zugates, Robert Langer, and Daniel G. Anderson
Systemic Delivery and Preclinical Evaluation of Nanoparticles Containing Antisense Oligonucleotides and siRNAs
Chuanbo Zhang, Joseph T. Newsome, Rajshree Mewani, Jin Pei, Prafulla C. Gokhale, and Usha N. Kasid
Peptide-based Delivery of Steric-block PNA Oligonucleotides
Said Abes, Gabriela D. Ivanova, Rachida Abes, Andrey A. Arzumanov, Donna Williams, David Owen, Bernard Lebleu and Michael J. Gait
Characterizing Peptide Mediated DNA Internalization in Human Cancer Cells
Anders Wittrup and Mattias Belting
Selection and Characterization of Antibodies from Phage Display Libraries against Internalizing Membrane Antigens
Johan Fransson and Carl A. K. Borrebaeck
Artificial Membrane Models for the Study of Macromolecular Delivery
Lena Maler and Astrid Graslund
Enhanced Delivery of Macromolecules into Cells by Electroendocytosis
Alexander Barbul, Yulia Antov, Yosef Rosenberg and Rafi Korenstein
In Vitro Systems for Studying Epithelial Transport of Macromolecules
Nicole Daum, Andrea Neumeyer, BirgitWahl, Michael Bur, Claus-Michael Lehr
Preparation of Macromolecule-containing Dry Powders for Pulmonary Delivery
Kelly S. Kraft and Marshall Grant
Macromolecular Delivery Across the Blood-Brain Barrier
Kullervo Hynynen
Positron Emission Tomography (PET) and Macromolecular Delivery In Vivo
Ludwig G. Strauss and Antonia Dimitrakopoulou-Strauss
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: October, 2008
Pages: 216
Weight: 500g
Availability: Available
Subcategories: Pharmacology
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