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Main description:
Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to be chiral and only about 25% are administered as pure enantiomers. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). In several cases, unwanted side effects or even toxic effects may occur with the inactive enantiomer (distomer). Even if the side effects are not that drastic, the inactive enantiomer has to be meta- lized, which represents an unnecessary burden for the organism. The admin- tration of pure, pharmacologically active enantiomers is therefore of great importance. The ideal way to get to pure enantiomers would be by enantioselective synthesis. However, this approach is usually expensive and not often practicable. Usually, the racemates are obtained in a synthesis, and the separation of the enantiomers on a preparative scale is necessary.
On the other hand, there is also a great demand for methods of enantiomer separation on an analytical scale for controlling synthesis, checking for racemization p- cesses, controlling enantiomeric purity, and for pharmacokinetic studies. C- ventional methods for enantiomer separation on a preparative scale are fractionated crystallization, the formation of diastereomeric pairs followed by repeated recrystallization, and enzymatic procedures. In recent years, ch- matographic methods such as gas chromatography and, especially, liquid ch- matography have attracted increasing interest for chiral separation, both on analytical and preparative scales.
Contents:
Chiral Separation Principles: An Introduction
Gerald Gubitz and Martin G. Schmid
Separation of Enantiomers by Thin-Layer Chromatography: An Overview
Kurt Gunther, Peter Richter, and Klaus Moeller
Cyclodextrin-Based Chiral Stationary Phases for Liquid Chromatography: A Twenty-Year Overview
Clifford R. Mitchell and Daniel W. Armstrong
Enantiomeric Separations by HPLC Using Macrocyclic Glycopeptide-Based Chiral Stationary Phases: An Overview
Tom Ling Xiao and Daniel W. Armstrong
Chiral Separation by HPLC Using Polysaccharide-Based Chiral Stationary Phases
Chiyo Yamamoto and Yoshio Okamoto
Applications of Polysaccharide-Based Chiral Stationary Phases for Resolution of Different Compound Classes
Hassan Y. Aboul-Enein and Imran Ali
Chiral Separation by HPLC With Pirkle-Type Chiral Stationary Phases
Myung Ho Hyun and Yoon Jae Cho
Chiral Separation by HPLC Using the Ligand-Exchange Principle
Vadim A. Davankov
Chiral Separations by HPLC Using Molecularly Imprinted Polymers
Peter Spegel, Lars I. Andersson, and Staffan Nilsson
Indirect Enantioseparation by HPLC Using Chiral Benzofurazan-Bearing Reagents
Toshimasa Toyo'oka
Separation of the Racemic Trans-Stilbene Oxide by Sub-/Supercritical Fluid Chromatography
Leo Hsu, Genevieve Kennedy, and Gerald Terfloth
Chiral Separations Using Macrocyclic Antibiotics in Capillary Electrophoresis
Timothy J. Ward and Colette M. Rabai
Enantioresolutions by Capillary Electrophoresis Using Glycopeptide Antibiotics
Salvatore Fanali
Separation of Enantiomers by Capillary Electrophoresis Using Cyclodextrins
Wioleta Maruszak, Martin G. Schmid, Gerald Gubitz, Elzbieta Ekiert, and Marek Trojanowicz
Chiral Separations by Capillary Electrophoresis Using Proteins as Chiral Selectors
Jun Haginaka
Cellulases asChiral Selectors in Capillary Electrophoresis
Gunnar Johansson, Roland Isaksson, and Goeran Pettersson
Use of Chiral Crown Ethers in Capillary Electrophoresis
Martin G. Schmid and Gerald Gubitz
Chiral Separations by Capillary Electrophoresis Using Cinchona Alkaloid Derivatives as Chiral Counter-Ions
Michael Lammerhofer and Wolfgang Lindner
Chiral Separation by Capillary Electrophoresis Using Polysaccharides
Hiroyuki Nishi
Chiral Micellar Electrokinetic Chromatography
Koji Otsuka and Shigeru Terabe
Chiral Separation by Capillary Electrophoresis in Nonaqueous Medium
Marja-Liisa Riekkola and Heli Siren
Chiral Ligand-Exchange Capillary Electrophoresis and Capillary Electrochromatography
Martin G. Schmid and Gerald Gubitz
Enantioseparation in Capillary Chromatography and Capillary Electrochromatography Using Polysaccharide-Type Chiral Stationary Phases
Bezhan Chankvetadze
Chiral Separation by Capillary Electrochromatography Using Cyclodextrin Phases
Dorothee Wistuba, Jingwu Kang, and Volker Schurig
Chiral Separations by Capillary Electrochromatography Using Molecularly Imprinted Polymers
Peter Spegel, Jakob Nilsson, and Staffan Nilsson
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2010
Pages: 446
Weight: 756g
Availability: Available
Subcategories: Biochemistry
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