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MORE ABOUT THIS BOOK
Main description:
Biological interactions of visible light with photosensitizers have been studied for over a century while controlled clinical applications of light and photosensitizers to treat solid tumors, known as photodynamic therapy, have been evolving since the mid 1970's. In Photodynamic Therapy: Methods and Protocols, leading PDT scientists and clinicians provide the first comprehensive collection of methods and protocols specifically related to relevant mechanistic, dosimetric, preclinical, and clinical procedures used in current PDT research. Reflecting the growing number of studies demonstrating that immunological, tumor microenvironmental, and vascular responses are all contributing to PDT treatment outcomes, the contents of this volume move beyond the more traditional PDT concepts in order to investigate the numerous signal transduction and cell death pathways involved. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Photodynamic Therapy: Methods and Protocols is an ideal guide for new investigators just starting out in PDT research as well as seasoned investigators changing the direction of their research with the intention of exploring this vital field of study.
Contents:
1. Introduction
Thomas J. Dougherty
2. Death and Survival Signals in Photodynamic Therapy
Michael Dewaele, Tom Verfaillie, Wim Martinet, and Patrizia Agostinis
3. Photodynamic Therapy and Cell Death Pathways
David Kessel and Nancy L. Oleinick
4. Identification of MAPKinase Pathways Involved in COX-2 Expression Following Photofrin Photodynamic Therapy
Marian Luna, Angela Ferrario, Sam Wong, and Charles J. Gomer
5. Metronomic PDT and Cell Death Pathways
Gurmit Singh, Omar Alqawi, and Myrna Espiritu
6. How to Monitor NF-kB Activation after Photodynamic Therapy
Isabelle Coupienne, Jacques Piette, and Sebastien Bontems
7. Application of 5-Aminolevulinic Acid and Its Derivatives for Photodynamic Therapy In vitro and In vivo
Asta Juzeniene, Petras Juzenas, and Johan Moan
8. Hypoxia and Perfusion Labeling During Photodynamic Therapy
Theresa M. Busch
9. Targeting the Tumor Microenvironment Using Photodynamic Therapy Combined with Inhibitors of Cyclooxygenase-2 or Vascular Endothelial Growth Factor
Angela Ferrario and Charles J. Gomer
10. Photochemical Internalization (PCI): A Technology for Drug Delivery
Kristian Berg, Anette Weyergang, Lina Prasmickaite, Anette Bonsted, Anders Hogset, Marie-Therese R. Strand, Ernst Wagner, and Pal K. Selbo
11. Photodynamic Therapy-Generated Cancer Vaccines
Mladen Korbelik
12. Antimicrobial Photodynamic Inactivation and Photodynamic Therapy for Infections
Liyi Huang, Tianhong Dai, and Michael R. Hamblin
13. Photodynamic Therapy of Bacterial and Fungal Biofilm Infections
Merrill A. Biel
14. Calculation of Cellular Oxygen Concentration for Photodynamic Therapy In vitro
Michael S. Patterson and Emma Mazurek
15. Fluorescent MolecularImaging and Dosimetry Tools in Photodynamic Therapy
Brian W. Pogue, Kimberley S. Samkoe, Summer L. Gibbs-Strauss, and Scott C. Davis
16. Bifunctional Agents for Imaging and Therapy
Ravindra K. Pandey, Nadine S. James, Yihui Chen, Joseph Missert, and Munawar Sajjad
17. Photodynamic Diagnosis and Therapy and the Brain
Herwig Kostron
18. Photodynamic Therapy of Head and Neck Cancers
Merrill A. Biel
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: May, 2010
Pages: 312
Weight: 850g
Availability: Available
Subcategories: Counselling & Therapy, General Issues, Pathology
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