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Main description:
We are currently experiencing a fundamental shift in the way in which we approach the characterization of cancer. Never before has the make up of cancer tissues and individual cells been so exhaustively researched and char- terized. We are now capable of producing molecular "fingerprints" that ch- acterize the expression of all known and unknown genes within tumors and their surrounding tissues. More than 30,000 different genes may be measured in each patient's tumor in a single experiment. Simultaneously, novel therapies that exploit the molecular roadmap have been developed and are now being offered to patients. These novel agents, such as Glivec, Herceptin, Iressa, and others, specifically target individual genes within tumors and can produce d- matic responses in some patients. These drugs are only the forerunners of a coming tidal wave of novel therapeutics that individually target specific m- ecules within cancer cells-more than 300 such agents are currently in phase I or II clinical trials. This is an exciting time for cancer specialists and patients alike. However, if we have learned anything from the past 50 or more years of research into cancer, it is that Lord Beaverbrook, in founding the British national health service in the 1950s, was frighteningly prescient when he defined the primary goal of health care to be "Diagnosis, Diagnosis, Diag- sis. " Now, more than ever, it is essential that appropriate diagnostic methods and approaches are applied to the selection of patients for treatment.
Contents:
Prognostic and Predictive Factors
Michael Scott and Peter A. Hall
Assessment of Predictive Values of Tumor Markers
Joseph E. Roulston
Quality Assurance of Predictive Markers in Breast Cancer
Anthony Rhodes and Diana M. Barnes
Extraction of Nucleic Acid Templates
John M. S. Bartlett and Helen Speirs
Microdissection and Extraction of DNA From Archival Tissue
Joanne Edwards, James J. Going, and John M. S. Bartlett
Fluorescence In Situ Hybridization: Technical Overview
John M. S. Bartlett
HER2 FISH in Breast Cancer
John M. S. Bartlett and Amanda Forsyth
Fluorescence In Situ Hybridization for BCR-ABL
Mark W. Drummond, Elaine K. Allan, Andrew Pearce, and Tessa L. Holyoake
UroVysion (TM) Multiprobe FISH in Urinary Cytology
Lukas Bubendorf and Bruno Grilli
Chromogenic In Situ Hybridization in Tumor Pathology
Jorma Isola and Minna Tanner
Comparative Genomic Hybridization and Fluorescence In Situ Hybridization in Chronic Lymphocytic Leukemia
Marie Jarosova
Molecular Characterization of Human Papillomaviruses by PCR and In Situ Hybridization
Suzanne D. Vernon and Elizabeth R. Unger
A Nested RT-PCR Assay to Detect BCR/abl
Linda M. Wasserman
TP53 Mutation Detection by SSCP and Sequencing
Jenni Hakkarainen, Judith A. Welsh, and Kirsi H. Vahakangas
PCR Diagnosis of T-Cell Lymphoma in Paraffin-Embedded Bone Marrow Biopsies
Jean Benhattar and Sandra Gebhard
Circulating DNA Analysis: Protocols and Clinical Applications Using Taqman Assays
Kwan-Chee Allen Chan and Yuk-Ming Dennis Lo
Microsatellite Instability: Theory and Methods
Gillian Gifford and Robert Brown
The Diagnostic and Prognostic Significance of the Methylation Status of Myf-3 in Lymphoproliferative Disorders
Jeremy M. E. Taylor, Peter H. Kay, andDominic V. Spagnolo
Quantitative Analysis of PRAME for Detection of Minimal Residual Disease in Leukemia
Maiko Matsushita, Rie Yamazaki, and Yutaka Kawakami
Determination of Cyclin D1 Expression by Quantitative Real-Time, Reverse-Transcriptase Polymerase Chain Reaction
Karen E. Bijwaard and Jack H. Lichy
Detection of Telomerase hTERT Gene Expression and Its Splice Variants by RT-PCR
W. Nicol Keith and Stacey F. Hoare
Detection of Telomerase Enzyme Activity by TRAP Assay
W. Nicol Keith and Aileen J. Monaghan
Identification of TP53 Mutations in Human Cancers Using Oligonucleotide Microarrays
Wen-Hsiang Wen and Michael F. Press
Detection of K-ras Mutations by a Microelectronic DNA Chip
Evelyne Lopez-Crapez, Thierry Livache, Patrice Caillat, and Daniela Zsoldos
Microarray-Based CGH in Cancer
Ekaterina Pestova, Kim Wilber, and Walter King
Tissue Microarrays
Ronald Simon, Martina Mirlacher, Guido Sauter
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 408
Weight: 690g
Availability: Available
Subcategories: Pathology
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