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Main description:
Meningococcal septicemia and meningitis continue to be important causes of devastating illness, death, and long-term disability in both developed and resource-poor countries of the world. Few diseases have attracted as much public attention, or are as feared by parents and family members, as well as the medical staff who have to care for affected patients. The unexpected and unp- dictable occurrence of the disease in previously healthy children and young adults, its rapid progression, and the frequent occurrence of purpura fulminans with the resulting gangrene of limbs and digits and the requirement for mutilating s- gery, have all heightened both public and medical interest in the disease. Over the past two decades there has been a rapid increase in knowledge of many aspects of meningococcal disease as a result of intensive efforts by workers in many different fields: clinicians have studied the early presenting features and acute pathophysiology of the disorder; clinical scientists have explored the immunopathological mechanisms responsible for disease and have highlighted the important roles played by the host inflammatory response and pro-inflammatory cytokines in mediating damage to blood vessels and organs; microbiologists have developed new diagnostic methods; public health phy- cians and epidemiologists have improved surveillance techniques with the help of molecular tools provided by bacterial population biologists; and basic sci- tists have used the powerful new tools in molecular and cell biology to elucidate virulence mechanisms.
Contents:
Microbiology and Laboratory Diagnosis
Keith Cartwright
Isolation, Culture, and Identification of Meningococci from Clinical Specimens
Per Olcen and Hans Fredlund
PCR Diagnosis
Malcolm Guiver and Ray Borrow
Detection of Meningococcal Antigen by Latex Agglutination
Michael A. Sobanski, Rosemary A. Barnes, and W. Terence Coakley
Meningococcal Serology
Stephen J. Gray, Ray Borrow, and Edward B. Kaczmarski
Antibiotic Susceptibility Testing
Colin Block
Molecular Approach for the Study of Penicillin Resistance in Neisseria Meningitidis
Luisa Arreaza and Julio A. Vazquez
Overview: Epidemiology, Surveillance and Population Biology
Martin C. J. Maiden and Norman T. Begg
Serological Characterization
Betsy Kuipers, Germie van den Dobbelsteen, Elisabeth Wedege, and Loek van Alphen
Pulsed-Field Gel Electrophoresis
Mark Achtman and Giovanna Morelli
Nucleotide Sequencing of Antigen Genes of Neisseria Meningitidis
Rachel Urwin
Multi-Locus Sequence Typing
Keith A. Jolley
Capsular Operons
Ulrich Vogel, Heike Claus, and Matthias Frosch
Molecular Analysis of the Meningococcal LPS Expression
Michael P. Jennings, Andrew W. Berrington, and E. Richard Moxon
Genome Sequencing and Annotation
Alex C. Jeffries, Nigel J. Saunders, and Derek W. Hood
Representational Difference Analysis
Lucas D. Bowler, Aldert Bart, and Arie van der Ende
Managing Outbreaks: The Public Health Response
James M. Stuart
Global Trends in Meningococcal Disease
Dominique A. Caugant
Epidemiology, Surveillance, and Population Biology: Carriage Studies
Keith Cartwright
Surveillance of Meningococcal Disease in Europe
Norman Noah
Global Surveillance for Meningococcal Disease
Nancy E.Rosenstein
Epidemiology of Meningococcal Disease in North America
Andrew J. Pollard, David Scheifele, and Nancy Rosenstein
Computational Methods for Meningococcal Population Studies
Keith A. Jolley and Rachel Urwin
Clinical Studies and Host-Pathogen Interactions
F. Andrew I. Riordan and Andrew J. Pollard
Clinical Scoring Systems in Meningococcal Disease
Marino Festa and Bert Derkx
Quantitative Detection of Bacterial Lipopolysaccharides in Clinical Specimens
Petter Brandtzaeg, Reidun Ovstebo, and Peter Kierulf
Isolation and Analysis of Radiolabeled Meningococcal Endotoxin
Peter C. Giardina, Jerrold A. Weiss, Brad W. Gibson, and Michael A. Apicella
Cytokine Measurement In Vivo and In Vitro
Marcel van Deuren and Petter Brandtzaeg
Cytokine Bioassays
Nina-Beate Liabakk, Anders Waage, Egil Lien, Jorgen Stenvik, and Terje Espevik
Molecular Analysis of Gene-Polymorphisms Affecting the Host Response to Infection
Rudi G. J. Westendorp and Tom W.J. Huizinga
Coagulation Studies
Jan A. Hazelzet, C. Erik Hack, and Ronald de Groot
Complement Pathways and Meningococcal Disease: Diagnostic Aspects
Anders G. Sjoeholm, Lennart Truedsson, and Jens C. Jensenius
Evaluation of New Treatments for Meningococcal Disease
Simon Nadel, Iain Macintosh, and Michael Levin
Studies on the Effect of Neisserial Porins on Apoptosis of Mammalian Cells
Paola Massari and Lee M. Wetzler
Molecular Recognition Mechanisms of Meningococci: Identifying Receptor-Ligand Pairs Involved in Microbe-Host Interactions
Mumtaz Virji and Laura Serino
Experimental Nasopharyngeal Colonization by Neisseria Meningitidis Using Explant Organ Culture
Robert C. Read and Linda Goodwin
Invasion of the Central Nervous System by Neisseria Meningitidis
Colin Tinsley and Xavier
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 740
Weight: 1070g
Availability: Available
Subcategories: Infectious Diseases
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