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Main description:
An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immunotherapy, and the utilization of regulatory T cells. The protocols make it possible to study the adoptive transfer of tailored antigen-specific immune cells and to improve the clinical application of adoptive immunotherapy.
Contents:
Exploiting Dendritic Cells for Active Immunotherapy of Cancer and Chronic Infection
David O'Neill and Nina Bhardwaj
A Mathematical Approach for Optimizing Dendritic Cell-Based Immunotherapy
Gennady Bocharov, Neville J. Ford, and Burkhard Ludewig
Delivery of Tumor Antigens to Dendritic Cells Using Biodegradable Microspheres
Ying Waeckerle-Men, Bruno Gander, and Marcus Groettrup
RNA Transfection of Dendritic Cells
Frank Grunebach, Martin R. Muller, and Peter Brossart
Isolation and Generation of Clinical-Grade Dendritic Cells Using the CliniMACS System
John D. M. Campbell, Christoph Piechaczek, Gregor Winkels, Edith Schwamborn, Daniela Micheli, Sonja Hennemann, and Jurgen Schmitz
Generation of Clinical Grade Monocyte-Derived Dendritic Cells Using the CliniMACS System
Thomas Putz, Hubert Gander, Reinhold Ramoner, Claudia Zelle-Rieser, Andrea Rahm, Walter Nussbaumer, Georg Bartsch, Lorenz Hoeltl, and Martin Thurnher
Adenoviral Transduction of Dendritic Cells
Rienk Offringa, Kitty Kwappenberg, Martijn Rabelink, Delphine Rea, and Rob Hoeben
Generation of Autologous Peptide- and Protein-Pulsed Dendritic Cells for Patient-Specific Immunotherapy
David O'Neill and Nina Bhardwaj
Phenotypical and Functional Characterization of Clinical-Grade Dendritic Cells
I. Jolanda M. de Vries, Gosse J. Adema, Cornelis J. A. Punt, and Carl G. Figdor
Dendritic Cells in Clinical Trials for Multiple Myeloma
Volker L. Reichardt and Peter Brossart
Identification of Tumor-Associated Autoantigens With SEREX
OEzlem Tureci, Dirk Usener, Sandra Schneider, and Ugur Sahin
Application of Proteomics and Protein Analysis for Biomarker and Target Finding for Immunotherapy
Petra Weingarten, Petra Lutter, Andreas Wattenberg, Martin Blueggel, Sonja Bailey, Joachim Klose, Helmut E. Meyer, and Christoph Huels
Isolationand Expansion of Tumor-Reactive Cytotoxic T-Cell Clones for Adoptive Immunotherapy
Helga Bernhard, Burkhard Schmidt, Dirk H. Busch, and Christian Peschel
Tracking Adoptively Transferred Antigen-Specific T-Cells With Peptide/MHC Multimers
Norbert Meidenbauer and Andreas Mackensen
Gene Transfer of MHC-Restricted Receptors
Helmut W. H. G. Kessels, Monika C. Wolkers, and Ton N. M. Schumacher
Immunotherapy With CTL Restricted by Nonself MHC
Liquan Gao, Anne-Marie Downs, and Hans J. Stauss
Designing TCR for Cancer Immunotherapy
Ralf-Holger Voss, Jurgen Kuball, Matthias Theobald
Isolation and Expansion of Tumor-Specific CD4+ T-Cells by Means of Cytokine Secretion
Christian Becker
Methods for the Ex Vivo Characterization of Human CD8+ T Subsets Based on Gene Expression and Replicative History Analysis
Nathalie Rufer, Patrick Reichenbach, and Pedro Romero
Regulatory T Cells in Antitumor Therapy: Isolation and Functional Testing of CD4+CD25+ Regulatory T-Cells
Helmut Jonuleit and Edgar Schmitt
Monoclonal Antibody-Based Strategies in Autoimmunity and Transplantation
Lucienne Chatenoud
Producing Bispecific and Bifunctional Antibodies
Dipankar Das and Mavanur R. Suresh
Antibody-Cytokine Fusion Proteins for the Therapy of Cancer
Gustavo Helguera and Manuel L. Penichet
Synthesis and Biological Evaluation of a Paclitaxel Immunoconjugate
Ahmad Safavy and Kevin P. Raisch
Cytotoxic Tumor Targeting With scFv Antibody-Modified Liposomes
Cornelia Marty and Reto A. Schwendener
Intravenous Immunoglobin Treatment for Fibrosis, Atherosclerosis, and Malignant Conditions
Ilan Krause and Yehuda Shoenfeld
Study of T-Cell Costimulatory Blockade In Vivo at a Single Cell Level
Minh Diem Vu and Xian Chang Li
Stem Cell Transplantation: Graft-Mediated Antileukemia
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 518
Weight: 754g
Availability: Available
Subcategories: Immunology
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