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Main description:
A cutting-edge collection of readily reproducible molecular techniques to better understand, classify, and treat lymphoma. Among the highlights are methods to use immunoglobulin gene rearrangements as markers of clonality, to exploit patterns of somatic mutation in the variable regions to indicate at which stage transformation occurred, and to apply gene arrays to the question of biological heterogeneity in morphologically similar diseases. Research methodologies that are highly likely to become routine practice in the future, such as DNA microarray and immunoglobulin V-gene rearrangements, and measurement of minimal disease, are included. There are also molecular techniques for providing for producing novel therapeutics, such as a DNA vaccine with patient-specific sequences derived from the lymphoma in question.
Contents:
Purification of Primary Malignant B-Cells and Immunoblot Analysis of Bcl-2 Family Proteins
Claire Dallman and Graham Packham
Molecular Diagnosis of Lymphoma: Outcome Prediction by Gene Expression Profiling in Diffuse Large B-Cell Lymphoma
Kim Last, Silvana Debarnardi, and T. Andrew Lister
Demonstration of a Germinal Center Immunophenotype in Lymphomas by Immunocytochemistry and Flow Cytometry
Andrew Jack, Sharon Barrans, David Blythe, and Andrew Rawstron
Karyotyping Lymph Node Biopsies in Non-Hodgkin's Lymphoma
Fiona M. Ross and Christine J. Harrison
Identification of Lymphoma-Associated Antigens Using SEREX
Amanda P. Liggins, Barbara A. Guinn, and Alison H. Banham
Determining Mutational Status of Immunoglobulin V Genes in Chronic Lymphocytic Leukemia: A Useful Prognostic Indicator
Surinder S. Sahota, Gavin Babbage, Niklas Zojer, Christian H. Ottensmeier, and Freda K. Stevenson
Idiotype Gene Rescue in Follicular Lymphoma
Katy McCann, Surinder S. Sahota, Freda K. Stevenson, and Christian H. Ottensmeier
Immunoglobulin Gene Mutation Patterns and Heterogeneity of Marginal Zone Lymphoma
Mariella Dono and Manlio Ferrarini
T-Cell Receptor Molecular Diagnosis of T-Cell Lymphoma
Elizabeth Hodges, Anthony P. Williams, Susan Harris, and John L. Smith
Cloning of Immunoglobulin Chromosomal Translocations by Long-Distance Inverse Polymerase Chain Reaction
E. Loraine Karran, Takashi Sonoki, and Martin J. S. Dyer
Sequential Fluorescence In Situ Hybridization Analysis for Trisomy 12 in B-Cell Chronic Lymphocytic Leukemia
Viktoria Hjalmar
Splenic Marginal Zone Lymphoma: 7q Abnormalities
Rachel E. Ibbotson, Anton E. Parker, and David G. Oscier
BCL-6: Rearrangement and Mutation in Lymphoma
Simon D. Wagner and Jaspal S. Kaeda
Antibody Techniques Used in the Study of Anaplastic Lymphoma Kinase-Positive ALCL
Karen Pulford, Helen M. Roberton, and Margaret Jones
Identification of Anaplastic Lymphoma Kinase Variant Translocations Using 5'RACE
Luis Hernandez and Elias Campo
Follicular Lymphoma: Quantitation of Minimal Residual Disease by PCR of the t(14;18) Translocation
Angela Darby and John G. Gribben
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 360
Weight: 529g
Availability: Available
Subcategories: Oncology
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