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MORE ABOUT THIS BOOK
Main description:
A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.
Contents:
Part I. Measurements of DNA Damage, Cell Death, and Regulators of Cytotoxicity
In Vitro Micronucleus Technique to Predict Chemosensitivity
Michael Fenech
Cell Cycle and Drug Sensitivity
Aslamuzzaman Kazi and Q. Ping Dou
TUNEL Assay as a Measure of Chemotherapy-Induced Apoptosis
Robert Wieder
Apoptosis Assessment by the DNA Diffusion Assay
Narendra P. Singh
PARP Cleavage and Caspase Activity to Assess Chemosensitivity
Alok C. Bharti, Yasunari Takada, and Bharat B. Aggarwal
Diphenylamine Assay of DNA Fragmentation for Chemosensitivity Testing
Cicek Gercel-Taylor
Immunodetecting Members of the Bcl-2 Family of Proteins
Richard B. Lock and Kathleen M. Murphy
Correlation of Telomerase Activity and Telomere Length to Chemosensitivity
Yasuhiko Kiyozuka
Application of Silicon Sensor Technologies to Tumor Tissue In Vitro: Detection of Metabolic Correlates of Chemosensitivity
Pedro Mestres-Ventura, Andrea Morguet, Anette Schofer, Michael Laue, and Werner Schmidt
Overview of Tumor Cell Chemoresistance Mechanisms
Laura Gatti and Franco Zunino
Flow Cytometric Monitoring of Fluorescent Drug Retention and Efflux
Awtar Krishan and Ronald M. Hamelik
Flow Cytometric Measurement of Functional and Phenotypic P-Glycoprotein
Monica Pallis and Emma Das-Gupta
Measurement of Ceramide and Sphingolipid Metabolism in Tumors: Potential Modulation of Chemosensitivity
David E. Modrak
Part II. Genomics, Proteomics, and Chemosensitivity
Gene Expression Profiling to Characterize Anticancer Drug Sensitivity
James K. Breaux and Gerrit Los
Identifying Genes Related to Chemosensitivity Using Support Vector Machine
Lei Bao
Genetic Manipulation of Yeast to Identify Genes Involved in Regulation of Chemosensitivity
Giovanni L. Beretta and Paola Perego
Real-Time RT-PCR (Taqman (R)) of Tumor mRNA to Predict Sensitivity of Specimens to 5-Fluorouracil
Tetsuro Kubota
Use of Proteomics to Study Chemosensitivity
Julia Poland, Silke Wandschneider, Andrea Urbani, Sergio Bernardini, Giorgio Federici, and Pranav Sinha
Part III. In Vivo Animal Modeling of Chemosensitivity
Clinically Relevant Metastatic Breast Cancer Models to Study Chemosensitivity
Lee Su Kim and Janet E. Price
Orthotopic Metastatic (MetaMouse (R)) Models for Discovery and Development of Novel Chemotherapy
Robert M. Hoffman
Preclinical Testing of Antileukemic Drugs Using an In Vivo Model of Systemic Disease
Richard B. Lock, Natalia L. Liem, and Rachael A. Papa
Assessing Growth and Response to Therapy in Murine Tumor Models
C. Patrick Reynolds, Bee-Chun Sun, Yves A. DeClerck, and Rex A. Moats
Evaluation of Chemosensitivity of Micrometastatses with Green Fluorescent Protein Gene-Tagged Tumor Models in Mice
Hayao Nakanishi, Seiji Ito, Yoshinari Mochizuki, and Masae Tatematsu
99mTc-Annexin A5 Uptake and Imaging to Monitor Chemosensitivity
Tarik Z. Belhocine and Francis G. Blankenberg
Magnetic Resonance Imaging of Tumor Response to Chemotherapy
Richard Mazurchuk and Joseph A. Spernyak
Metabolic Monitoring of Chemosensitivity with 18FDG PET
Guy Jerusalem and Tarik Z. Belhocine
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 460
Weight: 776g
Availability: Available
Subcategories: Oncology
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