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Main description:
Despite the availability of an effective vaccine, there are still 400 million people, worldwide who are chronically infected with hepatitis B virus (HBV). For them, the vaccine, as currently applied, has no value. Given the possible consequences of HBV infection, the number of those chronically infected with HBV presents an enormous public health challenge. For example, the major etiology of hepatocellular carcinoma (HCC) is chronic infection with HBV. Although fifth in cancer incidence, worldwide, HCC/liver cancer is the third leading cause of cancer death. The high mortality as- ciated with HCC arises because the disease is often detected late and is unresponsive to treatment. The number of deaths caused by PHCC is expected to rise over the next 20 years. Those chronically infected with HBV have a life risk of death to HCC of between 10 and 25%. Even the limited efficacy of drugs for the treatment of chronic HBV helps underscore the point that this disease is responsive to therapy. Drugs that target the polymerase (e. g. , hepsera and lamivudine) and interferon alpha represent two distinct strategies and show that both conventional antiviral and immunothe- peutic approaches can be used in management. However, the current inventory of therapeutics is inadequate. Interferon alpha is of limited value, only parenterally ava- able, and fraught with adverse reactions.
Contents:
Part I. Viral-Specific Immunological and Other Host Responses
Studying Host Immune Responses Against Duck Hepatitis B Virus Infection
Darren S. Miller, Edward M. Bertram, Catherine A. Scougall, Ieva Kotlarski, and Allison R. Jilbert
Measurement of Cell-Mediated Immune Response in Woodchucks
Stephan Menne and Paul J. Cote
Study of Liver-Specific Expression of Cytokines During Woodchuck Hepatitis Virus Infection
Mengji Lu and Michael Roggendorf
Induction of Anti-Hepatitis B Virus Immune Responses Through DNA Immunization
Michael Geissler, Robert Weth, Christian F. Grimm, Doerte Ortmann, and Hubert E. Blum
Monitoring Gene Expression Using DNA Microarrays During Hepatitis B Virus Infection
Michael R. Beard and Stephen Locarnini
Determination of Hepatitis B Virus-Specific CD8+ T-Cell Activity in the Liver
Michelina Nascimbeni and Barbara Rehermann
Determining the Precursor Frequency of HBV Nucleocapsid Antigen-Specific T Cells
Jennifer A. Waters and Howard C. Thomas
Detection and Characterization of Virus-Specific CD8+ T Cells Using the Tetramer Approach
Xiao-Song He and Harry B. Greenberg
In Vitro Analysis of Hepatitis B Virus Specific CD4+ T Cells
Shilpa Chokshi and Nikolai V. Naoumov
Induction of Humoral and Cellular Immune Responses to Hepatitis Delta Virus Through DNA Immunizaiton in BALB/c Mice
Ren-Shiang Lee, Shih-Jer Hsu, Li-Rung Huang, Hui-Lin Wu, Shiou-Lin Lin, Ding-Shinn Chen, and Pei-Jer Chen
Part II. In Vitro and In Vivo Models
Infection of Primary Chimpanzee Hepatocytes with Recombinant Hepatitis D Virus Particles: A Surrogate Model for Hepatitis B Virus
Azeneth Barrera and Robert E. Lanford
Study of the Endocytosis and Intracellular Localization of Subviral Particles of Hepatitis B Virus in Primary Hepatocytes
Dieter Glebe and Wolfram H.Gerlich
The Tupaia Model for the Study of Hepatitis B Virus: Direct Infection and HBV Genome Transduction of Primary Tupaia Hepatocytes
Fritz von Weizsacker, Josef Koeck, Sabine MacNelly, Shaotang Ren, Hubert E. Blum, and Michael Nassal
Delivery of Hepatitis B Virus Therapeutic Agents Using Asialoglycoprotein Receptor-Based Liver-Specific Targeting
Masayoshi Konishi, Catherine H. Wu, and George Y. Wu
Woodchuck Hepatitis Virus Hepatocyte Culture Models
Norma D. Churchill and Tomasz I. Michalak
Duck Hepatitis B Virus Primary Hepatocyte Culture Model
Olivier Hantz and Fabien Zoulim
Enhancement of Infection of HepG2 Cells in Culture by Predigestion of Hepadnavirus with V8 Protease
Xuanyong Lu and Timothy M. Block
Construction of Recombinant Adenoviruses that Produce Infectious Hepatitis B Virus
Martin Sprinzl, Jerome Dumortier, and Ulrike Protzer
Baculovirus-Mediated Gene Transfer for the Study of Hepatitis B Virus
Harriet C. Isom, Ayman M. Abdelhamed, John P. Bilello, and Thomas G. Miller
Transgenic Hepatitis B Virus Mouse Model in the Study of Chemotherapy
John D. Morrey
Transplantation of Human Hepatocytes in Immunodeficient UPA Mice: A Model for the Study of Hepatitis B Virus
Joerg Petersen, Martin R. Burda, Maura Dandri, and Charles E. Rogler
Duck Hepatitis B Virus Model in the Study of Hepatitis B Virus
Lucyna Cova and Fabien Zoulim
Hepatitis B Virus Transgenic Severe Combined Immunodeficient Mouse Model of Acute and Chronic Liver Disease
Mark A. Feitelson, Jonathan D. Larkin, and Raymond F. Schinazi
The Chimpanzee Model: Contributions and Considerations for Studies of Hepatitis B Virus
Pascal Gagneux and Elaine A. Muchmore
Hepatitis B in Liver Transplant Recipients as a Special Model of Antiviral Drug Development
Robert G. Gish and Adil
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 600
Weight: 999g
Availability: Available
Subcategories: Infectious Diseases
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