(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.
The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and "reverse" Warburg effect--these topics and more are discussed in this volume.
Contents:
Chapter 1: Tumor cell metabolic reprogramming and drug targeting (Steven B. Kanner)
Chapter 2: Cancer metabolism: a nexus of matter, energy and reactive oxygen species (Paul M. Bingham, Shawn D. Stuart, Zuzana Zachar) Chapter 3: Regulating mitochondrial respiration in cancer (Teresa L. Serafim and Paulo J. Oliveira)
Chapter 4: Regulation of cancer cell metabolism by hypoxia (Ashleigh Pulkoski-Gross, Nikki A. Evensen and Jian Cao)
Chapter 5: Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs (Gernot Bruchelt, Rupert Handgretinger, Mirjam Weckenmann, Talia Hahn)
Chapter 6: Modulating autophagy and the "reverse Warburg effect" (Maria Vaccaro, Claudio D. Gonzalez, Silvia Alvarez and Alejandro Ropolo)
Chapter 7: Metabolic adaptation in reprogrammed cancer cells (Kevin Marks and Charles Kung)
Chapter 8: Targeting of PFKFB3 (Katarina Farnegardh, Maria Shoshan, Lars AEhrlund-Richter)
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: January, 2014
Pages: 240
Weight: 483g
Availability: Available
Subcategories: General Issues, Oncology, Pharmacology
From the same series
Nicola Curtin
Jorge J. Castillo
Moulay A. Alaoui-Jamali
Gail Lewis Phillips
Frank E. Koehn
Beverly A. Teicher
Gary J. Kelloff
Ryan J. Sullivan
Gary K Schwartz
Val R Adams
Antonio Tito Fojo
William D. Figg
Giovanni Melillo
Masaki Terabe
Yves Pommier
Derek LeRoith
Beverly A. Teicher
Ann L. Jackman
Jorge J. Castillo
Manuel Hidalgo
Vinata B. Lokeshwar
Beverly A. Teicher
Moulay A. Alaoui-Jamali
Saïd M. Sebti
Frank E. Koehn
Rebecca G. Bagley
Vitaly A. Polunovsky
Benjamin Bonavida
Beverly A. Teicher
Alan M. Gewirtz
Michael A Morse
Janusz W. Rak
J. Silvio Gutkind
Maryann Foote
Zahid H. Siddik
L. Harivardhan Reddy
Gavin J. Gordon
Masaki Terabe
Yves Pommier
Derek LeRoith
Neil J. Clendeninn
Howard L. Kaufman
John D. Haley
Manuel Hidalgo
Beverly A. Teicher
Ulrike Stein
Pat Price
Kelly K. Hunt
Mary L. Disis
David A. Gewirtz
Beverly A. Teicher
Sayed S. Daoud
Nicholas P. Farrell
Vinata B. Lokeshwar
Beverly A. Teicher
Giampietro Gasparini
Doriano Fabbro
Nicholas B. La Thangue
David E. Fisher
Beverly A. Teicher
John A. Hickman
Godefridus J. Peters
Julian Adams
Sonia Jakowlew
Antonio Giordano
Youcef M. Rustum
Michel Page
Gurmit Singh
Gary J. Kelloff
Moulay A. Alaoui-Jamali
Wafik S. El-Deiry
Keiko Hiyama
Amy M. Fulton
Federico Innocenti
Hak Choy
Sonia Jakowlew
Dennis M. Brown
Michael T. Lotze
Randall E. Harris
Eric Verdin
Benjamin Bonavida
Rebecca G. Bagley
Vitaly A. Polunovsky
Benjamin Bonavida
L. Harivardhan Reddy
V. Craig Jordan
Zahid H. Siddik
Erwin G. van Meir
Amy M. Fulton
Beverly A. Teicher
Keiko Hiyama
Gavin J. Gordon
David S. Ettinger
Federico Innocenti
John D. Haley
Benjamin Bonavida
Antonio Tito Fojo
Sonia Jakowlew
Sonia Jakowlew
Howard L. Kaufman
David A. Gewirtz
Beverly A. Teicher
Sayed S. Daoud
Pat Price
Michael T. Lotze
Ulrike Stein
Kelly K. Hunt
Godefridus J. Peters
Beverly A. Teicher
Eric Verdin