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Main description:
A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.
Contents:
Clinical Resistance to Alkylators: Status and Perspective
Brian Leyland-Jones
Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking Agents
Lawrence C. Panasci, Zhi-Yuan Xu, and Raquel Aloyz
Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs
Peter J. McHugh and John A. Hartley
Chemosensitization to Platinum-Based Anticancer Drugs: Current Trends and Future Prospects
Bertrand J. Jean-Claude
Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells
Istvan Boldogh, Kishor K. Bhakat, Dora Bocangel, Gokul C. Das, and Sankar Mitra
Stress-Activated Signal Transduction Pathways in DNA Damage Response: Implications for Repair, Arrest, and Therapeutic Interventions
Moulay A. Alaoui-Jamali, P. James Scrivens, and Martin Loignon
Overcoming Resistance to Alkylating Agents by Inhibitors of O6-Alkylguanine-DNA Alkyltransferase
Anthony E. Pegg and M. Eileen Dolan
Cellular Protection Against the Antitumor Drug Bleomycin
Dindial Ramotar, Huijie Wang, and Chaunhua He
Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death
Michele Rouleau and Guy G. Poirier
Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy
David Murray and Adrian C. Begg
Strand-Break Repair and Radiation Resistance
George Shenouda
V(D)J Recombination and DNA Double-Strand-Break Repair: From Immune Deficiency to Tumorigenesis
Despina Moshous and Jean-Pierre de Villartay
Inherited Disorders of Genomic Instability and Cancer Susceptibility
Gary M. Kupfer
Role of BRCA1 and BRCA2 in DNA Repair and Potential Impact on Therapeutics
Razqallah Hakem
Genetic Variations in DNARepair: Their Implications in Human Cancer Risk, Prevention, and Therapy
Jennifer J. Hu
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 376
Weight: 552g
Availability: Available
Subcategories: Oncology
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