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Main description:
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed "immune surveillance" in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.
Contents:
Preface
Bruce Zetter, PhD
Table of Contents:
PHYSIOLOGICAL PARAMETERS
1. Combination Strategies Targeting Hypoxia Inducible Factor 1 (HIF-1) for Cancer Therapy
Annamaria Rapisarda, PhD and Giovanni Melillo, MD
2. New Insights into Regulation of Tumor pH by Carbonic Anhydrases
Pawel Swietach,DPhil, Adrian L. Harris, DPhil/MBChB, and Richard D. Vaughan-Jones1,PhD
3. Hypoxia, Gene Expression and Metastasis
Olga V. Razorenova, PhD and Amato J. Giaccia, PhD
4. Molecular Mechanisms Regulating Expression and Function of Cancer-Associated Carbonic Anhydrase IX
Jaromir Pastorek, PhD and Silvia Pastorekova, PhD
5. Glycolytic Pathway as a Target for Tumor
Inhibition
Weiqin Lu, PhD and Peng Huang, MD/PhD
CELLULAR COMPONENTS
I. MALIGNANT CELLS
6. Aberrant DNA Methylation in Cancer Cells
Toshikazu Ushijima, MD/PhD
7. DNA Repair and Redox Signaling
Mark R. Kelley, PhD, Millie M Georgiadis, PhD, and Melissa L. Fishel, PhD
8. Cancer Stem Cells and Microenvironment
Mario Federico, MD and Antonio Giordano, MD/PhD
9. Epithelial-Mesenchymal Transition in Development and Diseases
Yadi Wu,PhD and Binhua P. Zhou, MD/PhD
10. Invasion and Metastasis
Douglas M. Noonan, PhD, Giuseppina Pennesi, MD, and Adriana Albini, PhD
11. Dormancy of Disseminated Tumor Cells: Reciprocal Crosstalk with the Microenvironment
Paloma Bragado, PhD, Aparna C. Ranganathan, PhD, and Julio Aguirre-Ghiso, PhD
II. VASCULATURE AND STROMA
12. Impact of Endothelial Progenitor Cells on Tumor Angiogenesis and Outcome of Antiangiogenic Therapy: New Perspectives on an Ongoing Controversy
Robert S. Kerbel1, PhD, Francesco Bertolini, MD/PhD, and Yuval Shaked, PhD
13. Bone Marrow Derived Mesenchymal Stem/Stromal Cells and Tumor Growth
Pravin J. Mishra, MS and Debabrata Banerjee, PhD
14. Integrin Signaling in Lymphangiogenesis
Barbara Garmy-Susini, PhD
15. Role of Pericytes in Resistance to Anti-Angiogenic Therapy
Koji Matsuo, MD, Chunhua Lu1, MD/PhD Mian M K. Shazad, MS/MD, Robert L. Coleman,MD, and Anil K. Sood, MD
16. Tumour-Promoting Stromal Fibroblasts in Human Carcinomas
Urszula M. Polanska, Msc/PhD, Kieran T. Mellody, BSc./MPhil., and Akira Orimo, MD/PhD*
III. IMMUNE-MEDIATED CELLS
17. Mast cells and tumor microenvironment
Theoharis C. Theoharides, MS/MD/PhD, Konstantinos-Dionysios Alysandratos, MD, Asimenia Angelidou, MD, and Bodi Zhang, MD/MPH
18. Macrophages in the Tumor Microenvironment
Monica Escorcio-Correia, PhD and Thorsten Hagemann, MD/PhD
19. The Prognostic Significance of Tumor-Infiltrating Lymphocytes
Ping Yu, MD/PhD and Yang-Xin Fu, MD/PhD
20. The Pro-Inflammatory Milieu and Pre-Malignant Epithelial Initiation
Adam Yagui-Beltran, MD, Lisa M. Coussens, PhD, Qizi Tang, PhD, and David Jablons, MD
21. Natural Killer Cells for Adoptive Immunotherapy
Jonathan E. Benjamin, MD/PhD and Sally Arai, MD
EXTRACELLULAR MATRIX
22. Fibronectin
Andreas Menrad, PhD
23. Collagen in Cancer
Janelle L. Lauer, PhD and Gregg B. Fields, PhD
24. Integrins and Cancer
Laurie G. Hudson,PhD and M. Sharon Stack, PhD
25. Matrix Metalloproteinases and Cancer Cell Invasion/Metastasis
Stanley Zucker, MD and Jian Cao, PhD
26. Tetraspanins and Cancer Metastasis
Margot Zoller, PhD
SECRETED PROTEINS
27. Chemokines and Metastasis
Kalyan C. Nannuru, PhD, Seema Singh, PhD, and Rakesh K. Singh, PhD
28. Transforming Growth Factor-? in Lung Cancer, Carcinogenesis and Metastasis
Sonia B. Jakowlew, PhD
29. Cooperative Interactions Between Integrins and Growth Factors in Pathological Angiogenesis
Jennifer M. Roth, MS, Eric Tweedie, BS, and Peter C. Brooks, PhD
30. The Extracellular Matrix and the Growth and Survival of Tumors
Yves DeClerck, MD
31. Secreted Growth Factors as Therapeutic Targets
Beverly A. Teicher, PhD
32. Adrenomedullin in Tumor Development
Rebecca G. Bagley, MS
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: September, 2010
Pages: 318
Weight: 1475g
Availability: Available
Subcategories: Oncology, Pharmacology
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