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MORE ABOUT THIS BOOK
Main description:
An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
Contents:
Mammalian Cell Death Pathways: Intrinsic and Extrinsic
E. Robert McDonald III and Wafik S. El-Deiry
Resistance to Apoptosis in Cancer Therapy
David J. McConkey
Structures of TNF Receptors and Their Interactions With Ligands
Sarah G. Hymowitz and Abraham M. de Vos
Death Receptor Signaling in Embryonic Ectodermal Development
Preet M. Chaudhary
Adaptor Proteins in Death Receptor Signaling
Nien-Jung Chen and Wen-Chen Yeh
Caspase Activation by the Extrinsic Pathway
Xiaolu Yang
Death Signaling and Therapeutic Applications of TRAIL
Mi-Hyang Kim and Dai-Wu Seol
Death Receptor Mutations
Sug Hyung Lee, Nam Jin Yoo, and Jung Young Lee
Regulation of Death Receptors
Udo Kontny and Heinrich Kovar
Regulation of TRAIL Receptor Expression in Human Melanoma
Peter Hersey, Si Yi Zhang, and Xu Dong Zhang
Regulation of Death Receptors by Synthetic Retinoids
Shi-Yong Sun
Role of p53 in Regulation of Death Receptors
Rishu Takimoto
Proapoptotic Gene Silencing Via Methylation in Human Tumors
Tanya Tekautz, Tal Teitz, Jill M. Lahti, and Vincent J. Kidd
Regulation of Death Receptor-Induced Apoptosis by NF-kB and Interferon Signaling Pathways: Implications for Cancer Therapy
Rajani Ravi and Atul Bedi
TRAIL in Cancer Therapy
Mahaveer Swaroop Bhojani, Brian D. Ross, and Alnawaz Rehemtulla
Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma
Subrata Ray, John G. Hissong, Marcela Oancea, and Alex Almasan
Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors
Rudiger Goeke and Youhai H. Chen
Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors
Christina Voelkel-Johnson
Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer
James S. Norris,David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant, Charles Landen, Stephen Tomlinson, Jian-Yun Dong, Lina M. Obeid, and Yusuf Hannun
Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers
Lidong Zhang and Bingliang Fang
Combination of Chemotherapy and Death Ligands in Cancer Therapy
Simone Fulda and Klaus-Michael Debatin
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 388
Weight: 736g
Availability: Available
Subcategories: Oncology
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