(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
Leading researchers, from the Novartis group that pioneered Gleevec/Glivec (TM) and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.
Contents:
Protein Tyrosine Kinases as Targets for Cancer and Other Indications
Mark Pearson, Carlos Garcia-Echeverria, and Doriano Fabbro
Inhibitors of Signaling Interfaces: Targeting Src Homology 2 Domains in Drug Discovery
Carlos Garcia-Echeverria
PI3-Kinase Inhibition: A Target for Therapeutic Intervention
Peter M. Finan and Stephen G. Ward
Src as a Target for Pharmaceutical Intervention: Potential and Limitations
Mira Susa, Martin Missbach, Rainer Gamse, Michaela Kneissel, Thomas Buhl, Jurg A. Gasser, Markus Glatt, Terence O'Reilly, Anna Teti, and Jonathan Green
Activated FLT3 Receptor Tyrosine Kinase as a Therapeutic Target in Leukemia
Blanca Scheijen and James D. Griffin
JAK Kinases in Leukemias, Lymphomas, and Multiple Myeloma
Renate Burger and Martin Gramatzki
Glivec (R) (Gleevec (R), Imatinib, STI571): A Targeted Therapy for Chronic Myelogenous Leukemia
Elisabeth Buchdunger and Renaud Capedeville
Platelet-Derived Growth Factor: Normal Function, Role in Disease, and Application of PDGF Antagonists
Tobias Sjoeblom, Kristian Pietras, Arne OEstman, and Carl-Henrik Heldin
Structural Biology of Protein Tyrosine Kinases
Sandra W. Cowan-Jacob, Paul Ramage, Wilhelm Stark, Gabriele Fendrich, and Wolfgang Jahnke
Testing of Signal Transduction Inhibitors in Animal Models of Cancer
Terence O'Reilly and Robert Cozens
Phosphoproteomics in Drug Discovery and Development
Michel F. Moran, Jarrod A. Marto, Cynthia J. Brame, Olga Ornatsky, Mark M. Ross, Leticia M. Toledo-Sherman, Alfredo C. Castro, Brett Larsen, Henry Duewel, Christopher Hosfield, Christopher Orsi, Thodoros Topaloglou, Daniel Figeys, Jarrod A. Caldwell-Busby, and David R. Stover
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2010
Pages: 306
Weight: 468g
Availability: Available
Subcategories: Biochemistry
From the same series
Nicola Curtin
Jorge J. Castillo
Moulay A. Alaoui-Jamali
Gail Lewis Phillips
Frank E. Koehn
Beverly A. Teicher
Gary J. Kelloff
Ryan J. Sullivan
Gary K Schwartz
Val R Adams
Antonio Tito Fojo
William D. Figg
Steven Kanner
Giovanni Melillo
Masaki Terabe
Yves Pommier
Derek LeRoith
Beverly A. Teicher
Ann L. Jackman
Jorge J. Castillo
Manuel Hidalgo
Vinata B. Lokeshwar
Beverly A. Teicher
Moulay A. Alaoui-Jamali
Saïd M. Sebti
Frank E. Koehn
Rebecca G. Bagley
Vitaly A. Polunovsky
Benjamin Bonavida
Beverly A. Teicher
Alan M. Gewirtz
Michael A Morse
Janusz W. Rak
J. Silvio Gutkind
Maryann Foote
Zahid H. Siddik
L. Harivardhan Reddy
Gavin J. Gordon
Masaki Terabe
Yves Pommier
Derek LeRoith
Neil J. Clendeninn
Howard L. Kaufman
John D. Haley
Manuel Hidalgo
Beverly A. Teicher
Ulrike Stein
Pat Price
Kelly K. Hunt
Mary L. Disis
David A. Gewirtz
Beverly A. Teicher
Sayed S. Daoud
Nicholas P. Farrell
Vinata B. Lokeshwar
Beverly A. Teicher
Giampietro Gasparini
Nicholas B. La Thangue
David E. Fisher
Beverly A. Teicher
John A. Hickman
Godefridus J. Peters
Julian Adams
Sonia Jakowlew
Antonio Giordano
Youcef M. Rustum
Michel Page
Gurmit Singh
Gary J. Kelloff
Moulay A. Alaoui-Jamali
Wafik S. El-Deiry
Keiko Hiyama
Amy M. Fulton
Federico Innocenti
Hak Choy
Sonia Jakowlew
Dennis M. Brown
Michael T. Lotze
Randall E. Harris
Eric Verdin
Benjamin Bonavida
Rebecca G. Bagley
Vitaly A. Polunovsky
Benjamin Bonavida
L. Harivardhan Reddy
V. Craig Jordan
Zahid H. Siddik
Erwin G. van Meir
Amy M. Fulton
Beverly A. Teicher
Keiko Hiyama
Gavin J. Gordon
David S. Ettinger
Federico Innocenti
John D. Haley
Benjamin Bonavida
Antonio Tito Fojo
Sonia Jakowlew
Sonia Jakowlew
Howard L. Kaufman
David A. Gewirtz
Beverly A. Teicher
Sayed S. Daoud
Pat Price
Michael T. Lotze
Ulrike Stein
Kelly K. Hunt
Godefridus J. Peters
Beverly A. Teicher
Eric Verdin