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Main description:
Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.
Contents:
Part I: Pharmacological Considerations for Drug Delivery Systems in Cancer Medicine
Systemically Administered Drugs
Reginald B. Ewesuedo and Mark J. Ratain
Regional Administration of Antineoplastic Drugs
Maurie Markman
Theoretical Analyses and Simulations of Anticancer Drug Delivery
Ardith W. El-Kareh and Timothy W. Secomb
Part II: Technologies Available for Use in Cancer Drug Delivery Systems
Biopolymers for Parenteral Drug Delivery in Cancer Treatment
Wolfgang Friess
Hydrogels in Cancer Drug Delivery Systems
Sung-Joo Hwang, Namjin Baek, Haesun Park, and Kinam Park
Microparticle Drug Delivery Systems
Duane T. Birnbaum and Lisa Brannon-Peppas
Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future
Robert G. L. Shorr, Michael Bentley, Simon Zhsao, Richard Parker, and Brendan Whittle
Emulsions As Anticancer Delivery Systems
S. Esmail Tabibi
Part III. Current Applications: Products Approved or in Advanced Clinical Development
Liposomal Drug Delivery Systems for Cancer Therapy
Daryl C. Drummond, Dmitri Kirpotin, Christopher C. Benz, John W. Park, and Keelung Hong
Gliadel (R): A New Method for the Treatment of Malignant Brain Tumors
Francesco DiMeco, Henry Brem, Jon D. Weingart, and Alessandro Olivi
Intralesional Chemotherapy with Injectable Collagen Gel Formulations
Elaine K. Orenberg
Sustained-Release Drug Delivery with DepoFoam
Sankaram B. Mantripragada and Stephen B. Howell
Cancer Vaccines
Susanne Osanto
Part IV. Future Directions: Novel Cancer Drug Targets and Delivery Systems
Gene Therapy of Cancer
Susanne Osanto
Progress in Antisense Technology
Stanley T. Crooke
Tumor Vaccines
Francesco M. Marincola
Diagnosis and Treatment of HumanDisease Using Telomerase As a Novel Target
Lynne W. Elmore and Shawn E. Holt
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 402
Weight: 765g
Availability: Available
Subcategories: Oncology, Pharmacology
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