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MORE ABOUT THIS BOOK
Main description:
In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.
Contents:
Cancer Chemotherapy Based on E2F and the Retinoblastoma Pathway
William G. Kaelin, Jr
Myc Oncoproteins as Targets for Therapeutic Intervention in Tumorigenesis
Bernd Berwanger and Martin Eilers
The AP-1 Family of Transcription Factors: Structure, Regulation, and Functional Analysis in Mice
Marina Schorpp-Kistner, Peter Herrlich, and Peter Angel
Hypoxia-Induced Factor-1 as a Target for Anticancer Therapy
Shoumo Bhattacharya
Nuclear b-Catenin Signaling as a Target for Anticancer Drug Development
Eun Joo Chung, Paolo Bonvini, Ho Jung Oh, Len Neckers, and Jane Trepel
Histone Acetyltransferases as Potential Targets for Cancer Therapies
Stuart Thomson and Louis C. Mahadevan
Histone Deacetylases
Manfred Jung
Cyclin-Dependent Kinases and Their Small-Molecule Inhibitors in Cancer Therapy
R. Nagaraja Rao and Bharvin K. R. Patel
Mitogen-Activated Protein Kinase Cascades as Therapeutic Targets in Cancer
Antonio Chiloeches and Richard Marais
Mdm2 and ARF
Andrea Klotzbucher and Michael H. G. Kubbutat
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2
Anastasia Gabriel and Alan Ashworth
Human Papillomavirus: Targets for Therapeutic Intervention
David Pim, Miranda Thomas, and Lawrence Banks
Apoptin as an Anticancer Therapy
Mathieu H. M. Noteborn
E2F and Cancer Chemotherapy
Debabrata Banerjee and Joseph R. Bertino
Hypoxic Signaling Pathways as Targets for Anticancer Therapy
Heidi M. Sowter and Adrian L. Harris
Androgen Receptor and Estrogen Receptors
H. M. Oosterkamp and R. Bernards
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 364
Weight: 672g
Availability: Available
Subcategories: Oncology
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