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Main description:
Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
Contents:
Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches
OEzlem Tureci, Thorsten Klamp, Michael Koslowski, Sebastian Kreiter, and Ugur Sahin
Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens
Ludmila Muller, Stephanie McArdle, Evelyna Derhovanessian, Thomas Flad, Ashley Knights, Robert Rees, and Graham Pawelec
Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy
Lisa M. Harlan and Julie Y. Djeu
The Role of Immune Monitoring in Evaluating Cancer Immunotherapy
Holden T. Maecker
Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials
Susan Groshen
DNA Vaccines for Cancer Immunotherapy
Heesun Kwak and Howard L. Kaufman
Dendritic Cells
Weiping Zou and Tyler J. Curiel
Different Approaches to Dendritic Cell-Based Cancer Immunotherapy
Noweeda Mirza and Dmitry Gabrilovich
Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer
Malaya Bhattacharya-Chatterjee, Nitin Rohatgi, Sunil K. Chatterjee, Asim Saha, Rakesh Shukla, and Kenneth A. Foon
Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics
Jie Dai and Zihai Li
Tumor-Reactive T-Cells for Adoptive Immunotherapy
Helga Bernhard, Julia Neudorfer, Kerstin Gebhard, Heinke Conrad, Dirk H. Busch, and Christian Peschel
T-Cell Adoptive Immunotherapy of Cancer: From Translational Models to Clinical Significance
Peter A. Cohen, Mohamed Awad, and Suyu Shu
Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells
Jeffrey J. Roszkowski and Michael I. Nishimura
Harnessing the Potential of Graft-vs-Tumor
Nancy M. Hardy and Michael R. Bishop
Tumor-Induced Immune Suppression and Immune Escape: Mechanisms and Impact on the Outcome ofImmunotherapy of Malignant Disease
Michael Campoli and Soldano Ferrone
The Tumor Microenvironment: Regulation of Antitumor Immunity and Implications for Immunotherapy
George Coukos and Jose-Ramon Conejo-Garcia
Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity
Eduardo Davila and Esteban Celis
Fast-Lane Evolution in the Tumor Microenvironment
Gabriella Marincola and Francesco M. Marincola
Manipulating Immunological Checkpoints to Maximize Antitumor Immunity
Leisha A. Emens, R. Todd Reilly, and Elizabeth M. Jaffee
Interleukin-2 as Cancer Therapy
Joseph I. Clark and Kim A. Margolin
Biological and Clinical Properties of the Type 1 Interferons
Douglas W. Leaman, Shaun Rosebeck, and Ernest C. Borden
Promising g-Chain Cytokines for Cancer Immunotherapy: Interleukins-7, -15, and -21 as Vaccine Adjuvants, Growth Factors and Immunorestoratives
Terry J. Fry and Crystal L. Mackall
The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies
Sherif S. Farag and Michael A. Caligiuri
Antibody Therapy for Solid Tumors
Cristina I. Truica, Dorinda Rouch, and Carlos L. Arteaga
Antibody Therapy for Non-Hodgkin's Lymphoma
Stephen M. Ansell and Thomas E. Witzig
Approaches to In Vivo Imaging of Cancer Immunotherapy
George A. Vielhauer, Bond Almand, Mary L. Disis, David A. Mankoff, and Keith L. Knutson
Design Issues for Early-Stage Clinical Trials for Cancer Vaccines
Gina R. Petroni
Monoclonal Antibody Therapy of Cancer
Hossein Borghaei, Matthew K. Robinson, and Louis M. Weiner
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2010
Pages: 528
Weight: 1093g
Availability: Available
Subcategories: Oncology
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