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MORE ABOUT THIS BOOK
Main description:
A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.
Contents:
Part I. Introduction and Perspective
Antisense Methodology: An Assessment After 25 Years
Fritz Eckstein
Nucleic Acid Therapeutics: An Introduction
Alan M. Gewirtz
Part II. Basic Methodology
Targeted Genome Modification Via Triple Helix Formation
Faye A. Rogers and Peter M. Glazer
Therapeutic Applications of Ribozymes
John J. Rossi
Use of Catalytic DNA in Target Validation and Therapeutics
Lun-Quan Sun
Targeted Destruction of Small, Stable RNAs: Principles Applicable to Antisense Therapies
David A. Dunbar and Susan J. Baserga
Mechanism of Action of Antisense RNA in Eukaryotic Cells
Zuo Zhang and Gordon G. Carmichael
Part III. Delivery
The Transport of Oligonucleotides Into Cells
R. L. Juliano
Peptide-Mediated Delivery of Antisense Oligonucleotides and Related Material
Eric Vives, Jean Philippe Richard, and Bernard Lebleu
Molecular Vectors for Gene Delivery to Cancer Cells
Guy Zuber, Jean-Serge Remy, Patrick Erbacher, Pascale Belguise, and Jean-Paul Behr
Part IV. Targeting
Considerations on the Design of Antisense Oligonucleotides
Rosel Kretschmer-Kazemi Far, Jens M. Warnecke, and Georg Sczakiel
Identification of Hybridization Accessible Sequence in Messenger RNA
Lida K. Gifford, Ponzy Lu, and Alan M. Gewirtz
Part V. Clinical Targets
Nucleic Acids As Gene Targeting Therapeutics
Joanna B. Opalinska and Susan E. Shetzline
LY900003 (Isis 3521) and G3139 (Genasense; Oblimersen): Phosphorothioate Antisense Oligonucleotides With Pleiotropic Mechanisms of Action
C. A. Stein, Nathalie Dias, Luba Benimetskaya, Jan S. Jepsen, Johnathan C. H. Lai, and Anthony J. Raffo
Antisense Protein Kinase A-RIa Restores Normal Signal Transduction Signatures to Inhibit Tumor Growth
Yoon S.Cho-Chung
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: July, 2012
Pages: 221
Weight: 345g
Availability: Available
Subcategories: Oncology
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