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Main description:
A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Contents:
Part I. Antimutagens
Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane
Thomas W. Kensler and Paul Talalay
Chemoprevention by Isothiocyanates
Stephen S. Hecht
Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine
Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D'Agostini, Maria Bagnasco, and Roumen Balansky
Modifiers of Cytochrome(s) P450
John DiGiovanni and Heather E. Kleiner
Part II. Antiinflammatories
Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism
Gary B. Gordon, Gary J. Kelloff, and Caroline C. Sigman
Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention
Raymond N. DuBois
Lipoxygenases as Targets for Cancer Prevention
Susan M. Fischer and Russell D. Klein
Inducible Nitric Oxide Synthase as a Target for Chemoprevention
Lorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, and Curtis C. Harris
Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil
Timothy S. Wiedmann and Lee W. Wattenberg
Chemoprevention of Cancer by Curcumin
Bandaru S. Reddy and Chinthalapally V. Rao
Prostacyclin and Lung Cancer Chemoprevention
Robert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, and Mark W. Geraci
Part III. Nuclear Receptor Superfamily
Nuclear Receptor Superfamily: Targets for Chemoprevention
Julia A. Lawrence and Kapil Dhingra
A. Antiandrogens
Prostate Cancer Chemoprevention: 5a-Reductase Inhibitors
Jennifer E. Drisko and Siu-Long Yao
Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer
Mark S. Chapman,William Y. Chang, Andres Negro-Vilar, and Jeffrey N. Miner
B. Antiestrogens
Aromatase Inhibitors as Chemopreventives of Breast Cancer
Mitchell Dowsett and Judy E. Garber
Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators
Carolyn L. Smith
C. Natural Vitamin D and Synthetic Analogs
Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs
Kathryn Z. Guyton, Thomas W. Kensler, and Gary H. Posner
D. Retinoids
The Retinoids and Cancer Chemoprevention
Sutisak Kitareewan, Ian Pitha-Rowe, Yan Ma, Sarah J. Freemantle, and Ethan Dmitrovsky
E. Dehydroepiandrosterone and Structural Analogs
Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs
Arthur G. Schwartz and Laura L. Pashko
Part IV. Signal Transduction Modulators
ras Oncogene Inhibitors
Nancy E. Kohl
The Potential of EGFR-Targeted Agents in Cancer Prevention
Steven D. Averbuch and Fadlo R. Khuri
Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors
Paul Workman
Therapeutic Strategies Targeting Polyamines
Debora L. Kramer and Eugene W. Gerner
The Role of Phytoestrogens as Cancer Prevention Agents
Stephen Barnes and Coral A. Lamartiniere
Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids
Pamela L. Crowell and Michael N. Gould
Development of an Inhibitor of raf Kinase
Frank McCormick
Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention
Alessandro Sgambato and I. Bernard Weinstein
Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy
Melissa K. Reeder, Rifat Pamakcu, I. Bernard Weinstein, Kirk Hoffman, and W. Joseph
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 714
Weight: 3600g
Availability: Available
Subcategories: Oncology
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