BOOKS BY CATEGORY
Your Account
Cancer Chemoprevention
Volume 1: Promising Cancer Chemopreventive Agents
Price
Quantity
€304.99
(To see other currencies, click on price)
Paperback / softback
Add to basket  

MORE ABOUT THIS BOOK

Main description:

A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.


Contents:

Part I. Antimutagens

Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane
Thomas W. Kensler and Paul Talalay

Chemoprevention by Isothiocyanates
Stephen S. Hecht

Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine
Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D'Agostini, Maria Bagnasco, and Roumen Balansky

Modifiers of Cytochrome(s) P450
John DiGiovanni and Heather E. Kleiner

Part II. Antiinflammatories

Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism
Gary B. Gordon, Gary J. Kelloff, and Caroline C. Sigman

Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention
Raymond N. DuBois

Lipoxygenases as Targets for Cancer Prevention
Susan M. Fischer and Russell D. Klein

Inducible Nitric Oxide Synthase as a Target for Chemoprevention
Lorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, and Curtis C. Harris

Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil
Timothy S. Wiedmann and Lee W. Wattenberg

Chemoprevention of Cancer by Curcumin
Bandaru S. Reddy and Chinthalapally V. Rao

Prostacyclin and Lung Cancer Chemoprevention
Robert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, and Mark W. Geraci

Part III. Nuclear Receptor Superfamily

Nuclear Receptor Superfamily: Targets for Chemoprevention
Julia A. Lawrence and Kapil Dhingra

A. Antiandrogens

Prostate Cancer Chemoprevention: 5a-Reductase Inhibitors
Jennifer E. Drisko and Siu-Long Yao

Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer
Mark S. Chapman,William Y. Chang, Andres Negro-Vilar, and Jeffrey N. Miner

B. Antiestrogens

Aromatase Inhibitors as Chemopreventives of Breast Cancer
Mitchell Dowsett and Judy E. Garber

Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators
Carolyn L. Smith

C. Natural Vitamin D and Synthetic Analogs

Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs
Kathryn Z. Guyton, Thomas W. Kensler, and Gary H. Posner

D. Retinoids

The Retinoids and Cancer Chemoprevention
Sutisak Kitareewan, Ian Pitha-Rowe, Yan Ma, Sarah J. Freemantle, and Ethan Dmitrovsky

E. Dehydroepiandrosterone and Structural Analogs

Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs
Arthur G. Schwartz and Laura L. Pashko

Part IV. Signal Transduction Modulators

ras Oncogene Inhibitors
Nancy E. Kohl

The Potential of EGFR-Targeted Agents in Cancer Prevention
Steven D. Averbuch and Fadlo R. Khuri

Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors
Paul Workman

Therapeutic Strategies Targeting Polyamines
Debora L. Kramer and Eugene W. Gerner

The Role of Phytoestrogens as Cancer Prevention Agents
Stephen Barnes and Coral A. Lamartiniere

Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids
Pamela L. Crowell and Michael N. Gould

Development of an Inhibitor of raf Kinase
Frank McCormick

Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention
Alessandro Sgambato and I. Bernard Weinstein

Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy
Melissa K. Reeder, Rifat Pamakcu, I. Bernard Weinstein, Kirk Hoffman, and W. Joseph


PRODUCT DETAILS

ISBN-13: 9781617373428
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 714
Weight: 3600g
Availability: Available
Subcategories: Oncology
Related books
From the same series

CUSTOMER REVIEWS

Average Rating