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Main description:
Leading oncologists, hematologists, and nephrologists comprehensively review the role of HGFs in clinical practice, explain the molecular basis of their effects, and consider potential future developments. The authors focus on the use of HGFs in oncology, describing their cutting-edge application to patients with lung cancer, Hodgkin's and nonhodgkin's lymphoma, breast cancer, chronic lymphocytic leukemia, AIDS-related malignancies, myelodysplastic syndromes, and aplastic anemias. Among the HGFs described are granulocyte colony-stimulating factor, erythropoietc factors, thrombopoietic factors, and stem cell factor and its receptor, C-kit. To complete their survey, the contributors also consider the safety and economic implications of HGFs and the future potential for HGF antagonists in oncology.
Contents:
Part I. Basic Research
Introduction to Hematopoietic Growth Factors: A General Overview
George Morstyn and MaryAnn Foote
Animal Models of Hematopoietic Growth Factor Perturbations in Physiology and Pathology
Graham J. Lieschke
The Jak/Stat Pathway of Cytokine Signaling
Ben A. Croker and Nicos A. Nicola
Small-Molecule and Peptide Agonists: A Literature Review
Ellen G. Laber and C. Glenn Begley
Part II. Hematopoietic Growth Factors
Granulocyte Colony-Stimulating Factor
Graham Molineux
Erythropoietic Factors: Clinical Pharmacology and Pharmacokinetics
Steven Elliott, Anne C. Heatherington, and MaryAnn Foote
Thrombopoietin Factors
David J. Kuter
Stem Cell Factor and Its Receptor, c-Kit
Keith E. Langley
Hematopoietic Growth Factors: Preclinical Studies of Myeloid and Immune Reconstitution
Ann M. Farese and Thomas J. MacVittie
Part III. Use of Hematopoietic Growth Factors in Oncology
Commentary on the ASCO and ESMO Evidence-Based Clinical Practice Guidelines for the Use of Hematopoietic Colony-Stimulating Factors
Richard M. Fox
Neutropenia and the Problem of Fever and Infection in Patients With Cancer
David C. Dale
Thrombocytopenia and Platelet Transfusions in Patients With Cancer
Lawrence T. Goodnough
Hematopoietic Growth Factors in Lung Cancer
Johan F. Vansteenkiste and Christophe A. Dooms
Role of Hematopoietic Growth Factors As Adjuncts to the Treatment of Hodgkin's and Non-Hodgkin's Lymphomas
Marcie R. Tomblyn and Jane N. Winter
Use of Granulocyte Growth Factors in Breast Cancer
Eric D. Mininberg and Frankie Ann Holmes
Role of Cytokines in the Management of Chronic Lymphocytic Leukemia
Carol Ann Long
Hematopoietic Growth Factor Therapy for Myelodysplastic Syndromes and Aplastic Anemia
Jason Gotlib and Peter L. Greenberg
Use of Hematopoietic Growth Factors in AIDS-Related Malignancies
MaryAnn Foote
Part IV. Safety and Economic Implications
The Safety of Hematopoietic Growth Factors
Roy E. Smith and Barbara C. Good
Long-Term Safety of Filgrastim in Chronic Neutropenias
Karl Welte
Economics of Hematopoietic Growth Factors
Gary H. Lyman and Nicole M. Kuderer
Part V. Future Directions
Potential for Hematopoietic Growth Factor Antagonists in Oncology
Hayley S. Ramshaw, Timothy R. Hercus, Ian N. Olver, and Angel F. Lopez
Acronyms and Selected Abbreviations
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: July, 2012
Pages: 478
Weight: 920g
Availability: Available
Subcategories: Haematology
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