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Main description:
There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer.
Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs.
Road map to anticancer drug development from discovery to NDA submission
Discussion of molecular targets and preclinical screening
Development and validation of bioanalytical methods
Chapters on clinical trial design and phase 0, I, II, III clinical trials
Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents
Review of the drug development process from both laboratory and clinical perspectives
New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Contents:
Molecular Targets
Annunziata, Christina M. (et al.)
Preclinical Screening for New Anticancer Agents
Burger, Angelika M. (et al.)
Natural Product Screening
McKee, Tawnya C. (et al.)
Defining the Starting Dose: Should It Be mg/kg, mg/m
Gao, Bo (et al.)
Phase 0 Trials in Oncology
Kummar, Shivaani (et al.)
Phase I Trials in Oncology: Design and Endpoints
Glen, Hilary (et al.)
Quantitative Analytical Methods: Development and Clinical Considerations
Gardner, Erin R.
Validation and Control of Bioanalytical Methods
Karnes, H. Thomas (et al.)
Anticancer Clinical Pharmacology Overview
Dandamudi, Uday B. (et al.)
Pharmacokinetic Modeling
Li, Jing (et al.)
Pharmacometrics
Brar, Satjit S. (et al.)
Pharmacodynamic Modeling
Bauer, Kenneth S. (et al.)
Protein Binding
Sparreboom, Alex (et al.)
Metabolism (Non-CYP Enzymes)
Jamieson, David (et al.)
Pharmacogenomics and Cancer Therapy: Somatic and Germline Polymorphisms
Patel, Jai N. (et al.)
Cytochrome P450
Ando, Yuichi
Polymorphisms in Genes of Drug Targets and Metabolism
Bohanes, Pierre (et al.)
DNA Repair: ERCC1, Nucleotide Excision Repair, and Platinum Resistance
Reed, Eddie (et al.)
Drug Interactions
Rivory, Laurent P.
ABC Transporters: Involvement in Multidrug Resistance and Drug Disposition
Massey, Paul R. (et al.)
Solute Carriers
Ho, Richard H. (et al.)
High-Throughput Platforms in Drug Metabolism and Transport Pharmacogenetics
English, Bevin C. (et al.)
Intrathecal Administration
Kilburn, Lindsay B. (et al.)
Microdialysis
Combest, Austin J. (et al.)
Regional Drug Delivery for Inoperable Pulmonary Malignancies
Schrump, David S.
Blood-Brain Barrier and CNS Malignancy
Balmanoukian, Ani (et al.)
Radiation and Altering Clinical Pharmacology
Smart, DeeDee (et al.)
Therapeutic Cancer Vaccines: An Emerging Approach to Cancer Treatment
Madan, Ravi A. (et al.)
Recombinant Immunotoxins
Kreitman, Robert J.
Monoclonal Antibodies
Bai, Shuang (et al.)
Clinical Pharmacology in Pediatrics
Tagen, Michael (et al.)
Clinical Pharmacology in the Older Adult
Slattum, Patricia W. (et al.)
Organ Dysfunction Trials: Background, Historical Barriers, Progress in Overcoming Barriers, and Suggestions for Future Trials
Kummar, Shivaani (et al.)
Drug Formulations: How these Affects Anticancer Drug
Lagas, Jurjen S. (et al.)
Nanotechnology in Cancer
Janat-Amsbury, Margit M. (et al.)
Imaging in Drug Development
Kurdziel, Karen A. (et al.)
Exposure-Response Relationships of Anticancer Agents: Application in Drug Development and Drug Label
Rahman, Atiqur
The Role of Phase III Trials in Modern Drug Development
Murphy, Janet E. (et al.)
Clinical Trial Designs for Approval of New Anticancer Agents
Chadha, Manpreet K. (et al.)
Clinical Pharmacogenetics
Sachidanandam, Kamakshi (et al.)
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: January, 2014
Pages: 770
Weight: 1960g
Availability: Available
Subcategories: Pharmacology
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