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MORE ABOUT THIS BOOK
Main description:
Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.
Contents:
Part I. Basic Concepts in Oncogene Research
Genetic Basis of Cancer Progression
Susan J. Done and Jeremy A. Squire
The Molecular Basis of Chromosomal Instability in Human Cancer Cells
Daniel P. Cahill
Signal Transduction Networks: Ras as a Paradigm
Frank McCormick
Oncogenic Receptor Tyrosine Kinases
Mark H. Kirschbaum, Mina D. Marmor, and Yosef Yarden
Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis
Gretchen A. Murphy and Channing J. Der
The Interplay Between Tumor Suppressor Genes and Oncogenes in Tumorigenesis
Eric C. Holland
Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment
Amato J. Giaccia
Part II. The Functional Impact of Oncogene Expression on Cancer Cells-Therapeutic Implications
Deregulation of Cell Cycle Progression by Oncogenic Transformation
Marcelo L. Rodriguez-Puebla, Adrian M. Senderowicz, and Claudio J. Conti
Oncogenes as Regulators of Cell Survival: The Role of Oncogenes and Tumor Suppressor Genes in the Induction of Resistance to Anoikis and Hypoxia
Kirill Rosen and Jorge Filmus
Oncogenes and Tumor Angiogenesis
Janusz Rak and Robert S. Kerbel
Oncogenes as Therapeutic Targets to Prevent Metastasis
Ann F. Chambers and Hemanth J. Varghese
The Impact of Oncogenes on Tumor Maintenance
Senji Shirasawa and Takehiko Sasazuki
Primary and Secondary Events in Oncogene-Driven Tumor Development: Lessons from Transgenic Model Systems
Michaela Herzig and Gerhard Christofori
Part III. Oncogenes as Targets for Anticancer Therapy In Vivo
Targeting Oncogenes in Hematopoietic Malignancies
Michael E. O'Dwyer and Brian J. Druker
Clinical Evaluation of Agents Targeting Epidermal Growth Factor Receptor (EGFR) in Cancer
Edward H. Lin and James L. Abbruzzese
Inhibition of the HER-2/neu Oncogene: A Translational Research Model for the Development of Future Targeted Therapies
Gottfried E. Konecny, Jane Arboleda, Dennis J. Slamon, and Mark Pegram
Farnesyltransferase Inhibitors as Anticancer Agents
Adrienne D. Cox
Targeting Oncogenic Signaling Pathways in Human Astrocytomas
Gelareh Zadeh and Abhijit Guha
Targeting Oncogenes in Pediatric Malignancies
Giannoula Klement and Robert S. Kerbel
Inhibiting Signal Transduction as an Approach to Radiosensitizing Tumor Cells
Eric J. Bernhard, Anjali K. Gupta, Elizabeth Cohen-Jonathan, Ruth J. Muschel, Stephen M. Hahn, and W. Gillies McKenna
Oncogenes as Targets for Cancer Vaccines
Samir N. Khleif and Joseph A. Lucci, III
Bcl-2 Antisense Oligonucleotides Therapy for Cancer: Targeting the Mitochondria
Finbarr E. Cotter and Dean A. Fennell
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: July, 2012
Pages: 487
Weight: 950g
Availability: Available
Subcategories: Oncology
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