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Main description:
Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.
Contents:
Integrin Signaling, Kenneth M. Yamada and Erik H. J. Danen. Signal Transduction Through Tyrosine Kinase Growth Factor Receptors, Paolo Fedi and Stuart A. Aaronson. Signaling from TGF-b Receptors, Anita B. Roberts, Mark P. de Caestecker, and Robert J. Lechleider. The Wnt Signal Transduction Pathway, Grant D. Barish and Bart O. Williams. Signaling from G-Protein-Coupled Receptors to the Nucleus, Shigetomo Fukuhara, Maria Julia Marinissen, Mario Chiariello, and J. Silvio Gutkind. Proximal Events in T-Cell Activation, Joanne Sloan-Lancaster and Lawrence E. Samelson. Signal Transduction from the High Affinity IgE Receptor, Reuben P. Siraganian. Signaling Through Fas (CD95, APO-1) and Related Death Receptors, Richard M. Siegel, David A. Martin, Felicita Hornung, Erastus C. Dudley, Lixin Zheng, and Michael J. Lenardo. Signal Transduction to the Nucleus by MAP Kinase, Roger J. Davis. The Regulation of MAP Kinase Pathways by MAP Kinase Phosphatases, Kathleen Kelly and Yanfang Chu. Control of MAPK Signaling by Ste20- and Ste11-Like Kinases, Gary R. Fanger, Thomas K. Schlesinger, and Gary L. Johnson. Ras Signaling and Transformation, Geoffrey J. Clark, John P. O'Bryan, and Channing J. Der. Signaling Pathways Controlled by Rho Family GTP-Binding Proteins, Marc Symons. PI3-Kinases: Role in Signal Transduction, David A. Fruman and Lewis C. Cantley. PI3K-Related Kinases: Roles in Cell-Cycle Regulation and DNA Damage Responses, Randal S. Tibbetts and Robert T. Abraham. Integrative Signaling Through c-Abl: A Tyrosine Kinase with Nuclear and Cytoplasmic Functions, Jean Y. J. Wang. Src: A Model for Regulation of Intracellular Signaling Molecules, Pamela L. Schwartzberg. Inhibitors of Protein Kinase C and Related Receptors for the Lipophilic Second Messenger sn-1,2-Diacylglycerol, Peter M. Blumberg, Peter Acs, Dipak K. Bhattacharyya, and Patricia S. Lorenzo. Reactive Oxygen Species in Proliferative Signaling, Toren Finkel and Daniel M. Sullivan. Sphingolipid Metabolites in Signal Transduction, Sarah Spiegel and Sheldon Milstien. The Jak/Stat Signaling Cascade: Its Role in the Biological Effects of Interferons, Andrew C. Larner and Andrew Keightley. Regulation of Cell Growth and Death by p53, Kevin M. Ryan and Karen H. Vousden. Regulation of NF-kB Function: Novel Molecular Targets for Pharmacological Intervention, Frank Mercurio and Anthony M. Manning. Using Protein-Interaction Domains to Manipulate Signaling Pathways, Bruce J. Mayer. Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents, Alexander Levitzki. A Pharmacological Approach to the MAP Kinase Cascade, David T. Dudley and Alan R. Saltiel. Specific Inhibitors of p38 MAP Kinase, Peter R. Young. Farnesyltransferase Inhibitors: Anti-Ras or Anticancer Drugs?, Adrienne D. Cox and Channing J. Der. Targeted p53 Gene Therapy-Mediated Radiosensitization and Chemosensitization, Esther H. Chang, Liang Xu, and Kathleen F. Pirollo. Treatment of p53-Deficient Cancers by Adenovirus E1B-Region Mutants: From Basic Research to the Clinic, David H. Kirn. The Cell Cycle Inhibitor p27 as a Prognostic Marker in Human Tumors and a Novel Target for Therapeutic Intervention, Michele Pagano and Katya Ravid. Chemical Cyclin-Dependent Kinase Inhibitors: Therapeutic Implications, Edward A. Sausville and Adrian M. Senderowicz. Index.
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: July, 2012
Pages: 578
Weight: 1119g
Availability: Available
Subcategories: Pharmacology
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