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Main description:
Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy. The authors detail applications of combined modality therapy in lung, esophageal, breast, gastric, pancreatic, colon, and rectal cancers. They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer. A review of how to integrate new specific molecular targeted agents into multimodality therapy in the future.
Contents:
Part I. General/Background
Chemoradiation: Biological Principles and Perspectives
Hak Choy and Robert M. MacRae
Fluoropyrimidines as Radiation Sensitizers
Muhammad Wasif Saif and Robert B. Diasio
Part II. Mechanisms of Interaction of Specific Chemotherapeutic Agents with Radiation
The Role of Platinum Complexes in Combined Modality Therapy
Beverly A. Teicher
Taxanes in Combined Modality Therapy
Robert M. MacRae and Hak Choy
Camptothecin Radiation Sensitization
Tyvin A. Rich
The Role of Gemcitabine in Combined Modality Therapy
Jerome Landry, William Blackstock, Robert M. MacRae, Gary Yang, and Hak Choy
Part III. Clinical Applications
Chemoradiation Strategies for Patients with Malignant Gliomas
Heather A. Curry and Walter J. Curran, Jr.
Combined Modality Strategies in the Treatment of Head and Neck Cancer
Cathy Eng and Everett E. Vokes
The Role of Combined Modality Therapy for Stage III Nonsmall-Cell Lung Cancer
Roger W. Byhardt
Combined Modality Treatment of Small-Cell Lung Cancer
Julie R. Brahmer, Larry Kleinberg, and David S. Ettinger
The Role of Chemoradiation in the Management of Esophageal Cancer
Arlene Forastiere and Bapsi Chak
Combined Modality Therapy in Locally Advanced Breast Cancer
Silvia C. Formenti and Matthew Volm
Combined Modality Therapy for Gastric, Pancreatic, and Biliary Tract Carcinomas
Alexandria Phan and Jaffer A. Ajani
Chemoradiation in Therapy for Colon and Rectum Carcinoma
Jason H. Lee and Christopher G. Willett
Chemoradiotherapy in Muscle-Invasive Bladder Cancer
Bruce J. Roth
The Role of Combined Chemotherapy and Radiation Therapy in the Treatment of Gynecologic Malignancies
Patricia J. Eifel
Part IV. Specific Molecular Targeted Agents
Overview of Specific Molecular Targeted Agents for Combined Modality Therapy
Scott Saxman and Janet Dancey
Receptor Tyrosine Kinases as Therapeutic Targets in Solid Tumors
Stacy L. Moulder and Carlos L. Arteaga
Adenoviral p53 Gene Therapy Strategies in Nonsmall-Cell Lung Cancer
Stephen G. Swisher and Jack A. Roth
Tumor Microvasculature as a Therapeutic Target During Radiotherapy
Dennis E. Hallahan and Don Stacy
Cancer Drug Discovery and Development: Maximizing the Therapeutic Potential of Matrix Metalloproteinase Inhibitors for the Treatment of Cancer
Jeffrey S. Humphrey, Karen Price, Elora Gupta, Andrew Baxter, John Bird, Daryl Sonnichsen, and Joseph Naglich
The Role of Cyclooxygenase-2 Inhibitors in Combined Modality Therapy
Hong Pyo, Raymond N. DuBois, and Hak Choy
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 434
Weight: 824g
Availability: Available
Subcategories: Oncology
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