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Transforming Growth Factor-Beta in Cancer Therapy, Volume II
Cancer Treatment and Therapy
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Main description:

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim­ ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.


Details the role of TGF- ß in cancer treatment and therapy, including its role in development and progression of several different cancers

Conveniently divided into three easy-to-follow parts

Companion volume details the role of TGF- ß on basic and clinical biology

Back cover:

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor-ß in developing and advanced cancers. Part II details transforming growth factor-ß in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor-ß signaling for therapy.

This volume’s companion, Basic and Clinical Biology, examines transforming growth factor-ß signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.


Transforming Growth Factor-ß in Cancer Therapy
Volume 2: Cancer Treatment and Therapy
Sonia B. Jakowlew, Ph.D., Editor
The Humana Press, Inc., Publisher

In Memorium for Anita B. Roberts, PhD
John M. McPherson*

Sonia B. Jakowlew*

Carl-Henrick Heldin*


Part I. Transforming Growth Factor-ß in Developing and Advanced Cancers

1 Transforming Growth Factor-ß Signaling in Pancreas Development and
Pancreatic Cancer
Sushil Rane*, Huei-Min Lin, Ji-Hyeon Lee, and Wan Jiao

2 Role of Transforming Growth Factor-ß (TGF-ß) in the Pathogenesis of
Head and Neck Squamous Cell
Carcinoma (HNSCC)
Stephen M. Weber, Shi-Long Lu, Sophia Bernstein, and Xiao-Jing Wang*

3 TGF-ß, Smads and Cervical Cancer
Devarajan Karunagaran* and Goodwin Jinesh

4 TGF-ß Signaling and Biglycan in Pancreatic Cancer
Hendrik Ungefroren*

5 TGF-ß Signaling in Endometrial Cancer
Dagmara Piestrzeniewicz-Ulanska*, David H. McGuinnes, and Grant R.

6 TGF-ß Ligands, TGF-ß Receptors, and Lung Cancer
Guiying Wang, Rongmei Zhang, Xiaohua Hu, Jiucun Wang, Lindsey J. Leach,
and Zewei Luo*

7 Role of TGF-ß in Osteolytic Bone Metastases
Laurent Bartholin* and Thesesa A. Guise

8 Hormonal Regulation of Transforming Growth Factor-beta in Breast
Miriam Buck* and Cornelius Knabbe

9 TGF-ß Signaling in Esophageal Cancer
Minoru Fukuchi*, Hiroyuki Kato, and Hiroyuki Kuwano

10 TGF-beta and HER2/ErbB2 and Breast Cancer Progression
Natasa Todorovic-Rakovic*

11 TGF-beta dependent T Cell Regulation in Colitis and Colon Cancer
Christoph Becker* and Markus F. Neurath

12 Role of Transforming Growth Factor-beta in the Kidney - Physiology
and Pathology
Elena Gagliardini and Ariela Benigni*

13 Perturbations of TGF-ß Signaling in Leukocytes as Driversof
Leukemogenesis and Epithelial
Lawrence A. Wolfraim* and John J. Letterio

14 Transforming Growth Factor-ß in Brain Functions and Dysfunctions
Denis Vivien*, Karim Benchenane, and Carine Ali

15 Inhibition of TGF-ß Signaling in Multiple Myeloma and it's Bone
Marrow Environment
Hiroshi Yasui, Teru Hideshima, and Kenneth C. Anderson*

16 Key Roles of Smad3 in TGF-ß Responses in the Prostate
Kyung Song and David Danielpour*

17 Smad Signaling in Leukemic Growth and Differentiation: Crosstalk
Between Smad and Multiple
Pathways Through Activation of the TGF-ß Type I Receptor
Francis W. Ruscetti*, Salem Akel, Maria Birchenall-Roberts, Zhouhong
Cao, and Anita Roberts

Part II. Transforming Growth Factor-ß in Cancer Treatment and Therapy

18 High Throughput Screening of Protein Interaction Networks in the
TGFß Interactome: Understanding the
Signaling Mechanisms Driving Tumor Progression
Miriam Barrios-Rodiles, Alicia Viloria-Petit, Kevin R. Brown, Igor
Jurisica, and Jeffrey L.

19 Tumor Suppressor and Pro-Progression Roles for TGF-ß in Breast Cancer
Ethan Kohn* and Binwu Tang

20 Tumor Suppressors p53 and TGF-ß Converge to Regulate the
Alpha-fetoprotein - Oncodevelopmental
Tumor Marker
Deepti S. Wilkinson and Michelle Craig Barton*

21 TGF-ß1: Roles in DNA Damage Responses
Kumari L. Andarawewa, Julie Kirshner, Joni D. Mott, and Mary Helen

22 The Rationale For and Effects of Targeting TGF-beta for Glioma
Anita B. Hjelmeland* and Jeremy N. Rich

23 Tumor Suppressor Function of TGF-ß1 in T Cells
Ramireddy Bommireddy* and Thomas Doetschman

24 Therapeutic Effects of Adenovirus-mediated Gene Transfer of TGF-ß Signal Antagonists on Undesirable
Epithelial-mesenchymal Transition and Neovascularization
Shizuka Saika*

25 Role of TGF-ß in Tumor Protection


ISBN-13: 9781588297150
Publisher: Springer (Humana Press)
Publication date: February, 2008
Pages: 812
Weight: 1712g
Availability: POD
Subcategories: Oncology, Pathology
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Average Rating 

From the reviews:

"This volume … provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. … This will likely be of interest to those in the field as well as those who are new … . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. … This will be a great resource for researchers and clinicians … ." (James P Luyendyk, Doody’s Review Service, June, 2008)