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The Role of Microtubules in Cell Biology, Neurobiology, and Oncology
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Main description:

I want to thank all who contributed to this first edition for their hard work and professionalism, and especially for their patience. I hope the readers will find this volume as helpful as I have found it. There is no doubt that the family of proteins we call the tubulins and the microtubules that they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investi- tion is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Without the basic science knowledge that has been accumulated, to which the authors of this work have contributed greatly, we would not be in the position we find ourselves of increasingly understanding disease and advancing therapies. As I read the chapters, I was humbled to think of the insights that so many have contributed to this field, and again became aware of how the collaborative effort of so many is needed to understand the complexities of nature. By working together, many have helped to advance this field. Because of their efforts, we find ourselves with the wealth of knowledge contained in this book. This knowledge gives us so much insight even as it challenges us to continue working. Thanks again to all of the wonderful collaborators for their excellence and their patience. Tito Fojo, MD, PhD vii CONTENTS Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .


Feature:

Collects the most current microtubule research available


Investigates the potential of microtubules in cancer therapy


Written by leading anti-cancer researchers


Back cover:

The family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investigation is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available. Among the topics examined in this volume are compounds that interact with tubulin, mechanisms and regulation by microtubule-associated proteins and drugs, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases.


Without the basic scientific knowledge that has been accumulated – to which the contributors of this work have contributed greatly – we would not be in the position we find ourselves as we increasingly understand disease and advancing therapies. Microtubule Targets in Cancer Therapy contributes to this new knowledge, and the text will be an invaluable resource for cancer researchers, oncologists, pharmacologists, and medical chemists.


Contents:

1. An Overview of Compounds that Interact with Tubulin and their Effects on Microtubule Assembly.

Ernest Hamel

2. Molecular Mechanisms of Micotubule Acting Cancer Drugs.

J. J. Correia and S. Lobert

3. Microtubule Dynamics: Mechanisms and Regulation by Microtubule-Associated Proteins and Drugs in vitro and in cells

Mary Ann Jordan and Leslie Wilson

4. Microtubule Associated Proteins (MAPs) and Microtubule Interacting Proteins: Regulators of Microtubule Dynamics

Maria Kavallaris, Sima Don, Nicole M. Verrills

5. The Post-Translational Modifications of Tubulin

Richard F. Ludueña, and Asok Banerjee

6. The Isotypes of Tubulin: Distribution and Functional Significance

Richard F. Ludueña, and Asok Banerjee

7. The Tubulin Superfamily

Richard F. Ludueña, and Asok Banerjee

8. Tubulin Proteomics in Cancer

Pascal Verdier Pinard, Fang Wang, Ruth Hogue Angeletti , Susan Band Horwitz, and George A. Orr

9. Tubulin and Microtubule Structures

Eva Nogales and Kenneth H. Downing

10. Destabilizing Agents: Peptides and Depsipeptides

Lee M. Greenberger and Frank Loganzo

11. Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin

Susan L. Bane

12. Antimicrotubule Agents that Bind Covalently to Tubulin

Dan L. Sackett

13. Microtubule Stabilizing Agents

Susan Band Horwitz and Tito Fojo

14. Mechanisms of Resistance to Drugs that Interfere with Microtubule Assembly

Fernando Cabral

15. Resistance to Microtubule Targeting Drugs: Part II

Paraskevi Giannakakou and James P. Snyder

16. Microtubule Stabilizing Agent in Clinical Oncology: The Taxanes

Chris H. Takimoto and Muralidhar Beeram

17. Investigational anti-cancer agents targeting the microtubule.

Lyudmila A. Vereshchagina, Orit Scharf, and A. Dimitrios Colevas

18. MicrotubuleDamaging Agents and Apoptosis

Manon Carre and Diane Brauger

19. Microtubule targeting agents and the tumor vasculature

Raffaella. Giavazzi, K. Bonezzi and Giulia Taraboletti

20. Neurodegenerative Diseases: Tau Proteins in Neurodegenerative Diseases Other Than Alzheimer's Disease

André Delacourte, Nicolas Sergeant and Luc Buée

21. Structure, Function and Regulation of the Microtubule Associated Protein Tau

Janis Bunker and Stuart C. Feinstein


PRODUCT DETAILS

ISBN-13: 9781588292940
Publisher: Springer (Humana Press)
Publication date: June, 2008
Pages: 605
Weight: 1384g
Availability: POD
Subcategories: Biochemistry, Oncology, Pharmacology
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CUSTOMER REVIEWS

Average Rating 

From the reviews:

"This book is appropriate for laboratories with an interest in the biology of microtubules … . Each chapter is nicely illustrated, well referenced, and offers a timely evaluation of what is known about tubulin and microtubules, including how they are targeted therapeutically. … The color insert and the accompanying CD-ROM with all color figures are helpful. This is an excellent all-around reference appropriate for researchers or clinicians interested in the basic science of tubulins, microtubules, related diseases, and targeted therapy."(John D. Robertson, Doody’s Review Service, January, 2009)

“This book offers a wide and detailed discussion of drugs and methods for studying tubulins and microtubules … . The book is easy-reading and well organized by … well-detailed and itemized methodology of study, a helpful conclusion including tips for future interested investigators, and a long list of references serving a specific source of search. … Chapters added in the end of the book … very nicely wrap up the book for those interested in these areas and hopefully intending to acquire acknowledgement about it.” (Fábio Luís Forti, Brazilian Journal of Pharmaceutical Sciences, Vol. 47 (2), Summer, 2011)