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MORE ABOUT THIS BOOK
Main description:
PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors.
PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The "synthetic lethality" of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.
Contents:
Section 1: What PARP is and What it Does
1. History of the discovery of poly (ADP-ribose)
Takashi Sugimura and Sydney Shall
2. Discovery of the PARP superfamily and focus on the lesser exhibited but not lesser talented members
Elea Heberle, Jean-Christophe Ame, Giuditta Illuzzi, Francoise Dantzer, Valerie Schreiber
3. The role of PARPs in DNA Strand Break Repair
Stuart L. Rulten, Francoise Dantzer and Keith W. Caldecott
4. TIPs: Tankyrase Interacting Proteins
Susan Smith
5. PARP and Carcinogenesis
Junhui Wang, Akira Sato, Hiroaki Fujimori, Yoshio Miki, Mitsuko Masutani
6. Multitasking roles for poly(ADP-ribosyl)ation in aging and longevity
Aswin Mangerich and Alexander BurkleSection 2. NAD catalysis and the identification of inhibitors
7. Overview of PARP Inhibitor Design and Optimization
Dana Ferraris
8. Structure Based Design of PARP Inhibitors
Stacie S. Canan
Section 3. Chemo- and radiosensitisation in vitro and in vivo
9. Preclinical chemosensitization by PARP inhibitors
David R. Shalinsky, Cherrie K. Donawho. Gerrit Los, and Joanne P. Palma
10. Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase I inhibitors and alkylating agents
Junko Murai and Yves Pommier
11. Radiosensitisation by poly(ADP-ribose) polymerase inhibition
Charles Fouillade, Alexis Fouquin, Mohammed-Tayyib Boudra, Vincent Favaudon, Vincent Pennaneach, Janet Hall
12. The vasoactivity of PARP inhibitors
Cian M. McCrudden and Kaye J. Williams
Section 4. Synthetic lethality
13. Synthetic lethality with Homologous Recombination Repair defects
Helen E. Bryant, Sydney Shall
14. Targeting tumour hypoxia with PARP Inhibitors: Contextual synthetic lethality
Katarzyna B. Leszczynska, Nadya Temper, Robert G. Bristow and Ester M. Hammond
15. Other determinants of sensitivity
Naoyuki Okita and Atsushi Shibata
16. Synthetic sickness with molecularly targeted agents against the EGFR pathway
Jennifer A. Stanley and Eddy S Yang
17. Disruption of DNA repair by cell cycle and transcriptional CDK inhibition
Liam Cornell, Neil Johnson and Geoffrey I. Shapiro
18. Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations
Kiranjit K. Dhillon and Toshiyasu Taniguchi
19. PARP inhibitor resistance - what is beyond BRCA1 or BRCA2 restoration
Guotai Xu, Jos Jonkers, Sven Rottenberg
Section 5. Clinical status
20. Introduction to PARPi clinical trials and future directions
Ruth Plummer and Yvette Drew
21. Clinical trials investigating PARP inhibitors as single agents
Sheeba Irshad and Andrew Tutt
22. Clinical trials of PARP inhibitors with chemotherapy
Ashley K. Clift, Nicholas Coupe and Mark R. Middleton
23. Combination of PARP inhibitors with clinical radiotherapy
Ross Carruthers, Anthony J. Chalmers
24. Biomarkers for PARP Inhibitors
C. Dearman, Ricky A. Sharma, Nicola Curtin
PRODUCT DETAILS
Publisher: Springer (Birkhauser Verlag AG)
Publication date: June, 2015
Pages: 562
Weight: 652g
Availability: Available
Subcategories: General Issues, Oncology, Pharmacology
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