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Organism Models of Autism Spectrum Disorders
Series: Neuromethods
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Main description:

As autism is associated with many rare diseases, this extensive bench book examines how no one single model can be used; multiple organism models are needed, each one corresponding to one of the diseases or to one aspect of a disease. Split into five sections, Organism Models of Autism Spectrum Disorders explores selecting the good species for the specific disease, modeling autism spectrum disorders (ASD) at the brain level, studying communication and social interactions, using vertebrates or invertebrate models of ASD as defined by DSM-5R, as well as pursuing models of diseases associated with an increased incidence of ASDs. Written for the respected Neuromethods series, this detailed volume contains the kind of insight and useful, practical advice that ensures more successful results in the lab.

Comprehensive and handy, Organism Models of Autism Spectrum Disorders will benefit psychiatrists and geneticists, as well as behavioral researchers who, realizing how important it is to improve their knowledge through more molecular approaches, are looking for the most suitable organisms.


Contents:

Part I: Organism Models of Autism Spectrum Disorders: Selecting the Good Species

1. Organism Models: Choosing the Right Model

Nicolas Levy and Pierre L. Roubertoux

2. The Autistic Spectrum Disorders (ASD) : From the Clinics to the Molecular Analysis

Pierre L. Roubertoux and Sylvie Tordjman

3. Selecting the Right Species: Practical Information on Organism Models

Catherine Bartoli, Arnaud Blanchard, Christine Buske, Gwenaelle Collod-Beroud, Laurent Fasano, Christophe Scajola, and Pierre L. Roubertoux

4. Viewing Animal Models for Tuberous Sclerosis Complex in the Light of Evolution

Christopher J. Howe, Jaco Serfontein, R. Ellen R. Nisbet, and Petrus J. de Vries

Part II: Modeling Autism Spectrum Disorder at the Brain Level

5. In Vivo Imaging in Mice

Nathalie Baril, Muriel Roth, and Rym Djouri

6. Invertebrate Models of Synaptic Transmission in Autism Spectrum Disorders

Manuel Ruiz-Rubio, Fernando Calahorro, and M. Mar Gamez-del-Estal

7. Epigenetic Factors in Normal and Pathological Neuronal Development

Natacha Broucqsault, Cherif Badja, Marie-Cecile Gaillard, and Frederique Magdinier

8. Finding Endophenotypes for Autism Spectrum Disorders (ASD): cDNA Microarrays and Brain Transcripts

Patrice Bourgeois and Pierre Roubertoux

9. Serotonin Disturbance in Mouse Models of Autism Spectrum Disorders

Kota Tamada and Toru Takumi

Part III: Communication and Social Interactions

10. Communication and Language in Animals

Gene S. Fisch

11. Social Relationships in Nonhuman Primates: Potential Models of Pervasive Disorders

Vanessa A.D. Wilson and Alexander Weiss

12. Zebrafish Social Behaviour Testing in Developmental Brain Disorders

Christine Buske

Part IV: Mouse Models of Autism Spectrum Disorders as Defined by DSM-5R

13. Maintaining Mice for Neurobehavioral Examination

Pierre L. Roubertoux

14. Deficit in Social Relationships and Reduced Field of Interest in Mice

Pierre L. Roubertoux , Michele Carlier, and Sylvie Tordjman

15. Modeling Autism Spectrum Disorders Motor Deficits in Mice

Pierre L. Roubertoux and Catherine Bartoli

Part V: Modeling Diseases with a High Prevalence of Autism Spectrum Disorders

16. Neuro-Behavioral Testing of Mouse Models of Rett Syndrome

Jean-Christophe Roux and Laurent Villard

17. Mouse Models of Tuberous Sclerosis

Dan Ehninger

18. Use of the Zebrafish Model to Understand Behavioral Disorders Associated with Altered Oxytocin System Development: Implications for Autism and Prader-Willi Syndrome

Nicole Johnston and Eric Glasgow

19. Epilogue: Perspectives and Caveats

Pierre L. Roubertoux


PRODUCT DETAILS

ISBN-13: 9781493922499
Publisher: Springer (Humana Press Inc.)
Publication date: January, 2015
Pages: 520
Weight: 652g
Availability: Available
Subcategories: Neurology, Neuroscience, Psychiatry
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