(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology.
Contents:
Milligan: Identification and Analysis of Function of Heterotrimeric Guanine Nucleotide-Binding Proteins Expressed in Neural Tissue. Godfrey: Methods for the Analysis of Phosphoinositides and Inositol Phosphates. Taylor et al.: Inositol Trisphosphate Receptors and Intracellular Calcium: Experimental Approaches. Poenie: Measurement of Intracellular Calcium with Fluorescent Calcium Indicators. Moreton: Single-Cell Imaging Technology. Burgess: Analysis of Protein Kinase C Function. Potter: Synthetic Analogs of Intracellular Messengers. Murray: Methods in Cyclic Nucleotide Research. Parker: Caged Intracellular Messengers and the Inositol Phosphate Signaling Pathway. Morton: Protein Phosphorylation. Burgoyne: Investigation of the Intracellular Regulators and Components of the Exocytotic Pathway. Matthews/Lamb: Intracellular Messengers in Vertebrate Photoreceptors: Electrophysiological Techniques. Minke/Selinger: Intracellular Messengers in Invertebrate Photoreceptors Studied in Mutant Flies. Index.
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2013
Pages: 580
Weight: 873g
Availability: Available
Subcategories: Neuroscience
From the same series
Francisco Ciruela
Alon Korngreen
Judee K. Burgoon
David Walker
Nina Karpova
Gabriela K. Popescu
Jerome Y. Yager
Heather A. Bimonte-Nelson
Tetsuichiro Saito
Adalberto Merighi
Giselbert Hauptmann
Joost Verhaagen
Pierre L. Roubertoux
Kewal K. Jain
Wolfgang Blenau
Mario Tiberi
Vangelis Sakkalis
Benjamin R. Arenkiel
Jennie B. Leach
Johannes Hirrlinger
Alvaro Pascual-Leone
Theodore H. Schwartz
Eugenio F. Fornasiero
Antoine Triller
Fritjof Helmchen
Alan A. Boulton
Alan A. Boulton
Peter Thorn
Riccardo Brambilla
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Wolfgang Walz
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Wolfgang Walz
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Peter V. Nguyen
Stephane Marinesco
H. Aldskogius
Rolf Dermietzel
Paul M. Pilowsky
Giuseppe Di Giovanni
Ricardo Martinez Murillo
Nicole M. Avena
Klaus Ballanyi
Jean-Rene Martin
Bassem A. Hassan
Gerhard Grunder
Emilio Badoer
Allan V. Kalueff
Hideyuki Mukai
Todd D. Gould
Ole H. Petersen
Tommaso Fellin
Alexei Morozov
Yannis Karamanos
Alan A. Boulton
Stephen B. Dunnett
Stephen B. Dunnett
Todd D. Gould
Patricio O'Donnell
Ka Wan Li
Scott Q. Harper
Michael Aschner
James J. Chambers
Mary C. Olmstead
Illana Gozes
Peter Paul de Deyn
Robert P. Vertes
Andrea C. LeBlanc
Shlomo Seidman
Hugh C. Hemmings
Alan A. Boulton
Alan A. Boulton
Wolfgang Walz
Alan A. Boulton
Allan V. Kalueff
Allan V. Kalueff
Chao Ma
Jacob Raber
Ulrich Dirnagl
Iok-Hou Pang
Allan V. Kalueff
Kewal K. Jain
Prof. Alexei Verkhratsky
Todd D. Gould
Massimo Filippi
Scott C. Baraban
Illana Gozes
Wolfgang Walz