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MORE ABOUT THIS BOOK
Main description:
Aiming toward improvement in the safety, efficiency, and specificity of viral vectors for neurobiological research and clinical applications, Viral Vector Approaches in Neurobiology and Brain Diseases covers key aspects related to the use of viral vectors in neuroscience, with a major emphasis on basic mechanisms of synaptic plasticity, learning, and memory, as well as molecular neuropharmacology and experimental animal models of brain disorders. The volume begins by delving into features of the viral vectors currently available in neuroscience and their production methods, and it then continues onward to examples of successful applications of viral vector technology to psychiatric and memory research, current applications of viral vector technology in the context of neurological disorders, as well as various cutting-edge applications of viral vector technology to neuroscience, including optogenetics. Written for the Neuromethods series, the chapters of this book contain the kind of detailed description and implementation advice that promotes successful, repeatable results.
Practical and up to date, Viral Vector Approaches in Neurobiology and Brain Diseases will be useful not only to neurobiologists wishing to routinely use viral vectors in the laboratory but also to experienced scientists needing detailed new protocols for a variety of experimental applications.
Contents:
Part I: Types of Viral Vectors in Neuroscience Research
1. Lentiviral Vectors as Research Tools in Neurobiology: Design and Production
Alessandro Papale and Riccardo Brambilla
2. Recombinant Adenovirus in Neurobiology
Qian Li and Tong-Chuan He
3. Adeno-Associated Virus-Based Vectors
Nathalie Dutheil and Erwan Bezard
4. Herpes Simplex Virus 1 (HSV-1)-Based Vectors
Aldo Pourchet, Matias E. Melendez, Anna Greco, and Alberto L. Epstein
5. Alphavirus-Based Vectors
Kenneth Lundstrom
Part II: Viral Vectors in Memory Research and Psychiatric Diseases
6. Viral Vectors to Study Synaptic Function
Helene Marie
7. Using Viral Vectors to Study the Memory Trace in Mice
Asim J. Rashid, Chen Yan, and Sheena A. Josselyn
8. Development of Cell-Type Specific Viral Vectors to Tease Apart the Neural Circuitry that Contributes to Drug Addiction
Susan M. Ferguson and John F. Neumaier
9. Using Viral-Mediated Gene Transfer to Study Depressive-Like Behavior
Amy R. Furay and John F. Neumaier
Part III: Viral Vectors in Neurological Disorders
10. Gene Therapy for Parkinson's Disease
Erika Elgstrand Wettergren, Luis Quintino, Giuseppe Manfre, and Cecilia Lundberg
11. Lentiviral Vectors in Huntington's Disease Research and Therapy
Aurelie Delzor, Noelle Dufour, and Nicole Deglon
12. Application of Viral Vectors to Motor Neuron Disorders
Elisabeth Dirren and Bernard L. Schneider
Part IV: Applications of Viral Vector Technology to Neuroscience Research
13. In Vivo Gene Silencing by Virally Delivered MicroRNA
Eugenia V. Gurevich, Mohamed R. Ahmed, and Yonatan Carl
14. Viral Manipulation of Neural Stem/Precursor Cells
Nunzio Iraci, Giulia Elisabetta Tyzack, Chiara Cossetti, Clara Alfaro-Cervello, and Stefano Pluchino
15. Viral Vector-Based Techniques for Optogenetic Modulation In Vivo
Mathias Mahn, Shiri Ron, and Ofer Yizhar
16. Viral Vectors for Optogenetics of Hypothalamic Neuropeptides
H. Sophie Knobloch, Alexander Charlet, Ron Stoop, and Valery Grinevich
17. Viral Vectors in Primate Research: Examples from Parkinson's Disease Research
Gregory Porras, Benjamin Dehay, and Erwan Bezard
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: October, 2013
Pages: 345
Weight: 8269g
Availability: Available
Subcategories: Genetics, Neuroscience
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