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Serotonin Receptor Technologies
Series: Neuromethods
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Main description:

Reflecting a vast amount of new information concerning the functional characteristics of the various 5-HT receptor subtypes and the Na+-dependent serotonin transporter (SERT), this volume provides state of the art methodologies currently applied in serotonin research from leading experts in the field. Serotonin Receptor Technologies describes approaches that vary from molecular biological and biochemical techniques (e.g., regarding receptor dimerization), fluorescence microscopy and imaging applications, flow cytometry, the use of organotypic slice and cell cultures to the generation of genetically modified animal models and the development of sophisticated behavioral tests, thus covering a wide spectrum of techniques to study serotonergic signaling in detail. Written for the popular Neuromethods series, chapters include the kind of detail and practical advice that ensures successful results in the lab.

Authoritative and convenient, Serotonin Receptor Technologies serves to foster both basic and translational research aiming to further deepen our understanding of the various facets of aminergic systems, as well as to aid research on similar problems with related GPCRs and neurotransmitter transporters.


Contents:

Part I: Receptor Dimerization

1. Novel Approaches to Serotonin Receptor Interaction StudiesSylwia Lukasiewicz, Ewa Blasiak, Kinga Szafran, and Marta Dziedzicka-Wasylewska

2. Techniques for the Study of GPCR Heteromerization in Living Cells and Animal Models, Jose L. Moreno, Jeremy Seto, James B. Hanks, and Javier Gonzalez-Maeso

Part II: Manipulation and Analysis of Serotonergic Signaling in Brain Slices

3. Organotypic Slices and Biolistic Transfection for the Study of Serotonin Receptor Function in CNS Neuron Kelly McGregor, Jean-Claude Beique, and Rodrigo Andrade

Part III: Mouse Models to Study Serotonin-Associated Behavioral Disorder

4. Dissecting a Model of Depressive-Related Phenotype and Antidepressants Effects in 129S2/SvPas Mice Silvina L. Diaz and Luc Maroteaux

5. The Murine Serotonin Syndrome and the 5-HT1A Receptor: Behavioral Effects and Hypothermi Robert Haberzettl, Heidrun Fink, Silke Dietze, and Bettina Bert

6. 5-HT4 Receptor Subtype, -arrestin Level, and Rapid Onset Effects of Antidepressant Drugs Indira Mendez-David, Denis Joseph David, Jean-Philippe Guilloux, Rene Hen, and Alain Michel Gardier

Part IV: Serotonin Transporter

7. Autoshaping Memory Formation and Retention Loss: Are Serotonin and Other Neurotransmitter Transporters Involved Alfredo Meneses and Ruth Tellez

8. Flow Cytometry to Determine Serotonin Transporter Function in Human Peripheral Blood Cells Brendan S. Beikmann and Anne M. Andrews

Part V: Invertebrate Model Systems

9. Functional Genomics of Serotonin Receptors in Helminth Parasites: Elucidation of Receptor Function through RNA Interference (RNAi)Mohammed Rashid, Kevin MacDonald, and Paula Ribeiro

10. Visualization of the Serotonin System in Drosophila Brain: Immunofluorescence and Confocal Microscopy Charles D. Nichols and Kelly Jean Sherman

11. Serotonin Modulates Adult Neurogenesis in an Invertebrate Model: Approaches to Receptor Localization and Function Barbara S. Beltz, Yi Zhang, and Jeanne L. Benton

12. Immunolocalization of Serotonergic Neurons in Arthropod Developmental and Phylogenetic Neuroanatomy Torben Stemme and Michael Stern


PRODUCT DETAILS

ISBN-13: 9781493921867
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2014
Pages: 240
Weight: 6952g
Availability: Available
Subcategories: Neurology, Neuroscience
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