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Main description:
Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful Neuromethods (TM) series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field.
Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.
Contents:
1. The Open Field Test
Todd D. Gould, David T. Dao, and Colleen E. Kovacsics
2. Analysis of Grooming Behavior and its Utility in Studying Animal Stress, Anxiety, and Depression
Amanda N. Smolinsky, Carisa L. Bergner, Justin L. LaPorte, and Allan V. Kalueff
3. Digging in Mice: Marble Burying, Burrowing, and Direct Observation Reveal Changes in Mouse Behavior
Robert M.J. Deacon
4. Circadian and Light Modulation of Behavior
Cara M. Altimus, Tara A. LeGates, and Samer Hattar
5. Ultrasonic Vocalizations by Infant Mice: An Ethological Expression of Separation Anxiety
James T. Winslow
6. The Forced Swimming Test in Mice: A Suitable Model to Study Antidepressants
Martine Hascoet and Michel Bourin
7. The Tail Suspension Test: A Model for Characterizing Antidepressant Activity in Mice
Olivia F. O'Leary and John F. Cryan
8. Stress-Induced Hyperthermia in the Mouse
Christiaan Vinkers, Ruud van Oorschot, Berend Olivier, and Lucianne Groenink
9. Factors of Reproducibility of Anhedonia Induction in a Chronic Stress Depression Model in Mice
Tatyana Strekalova and Harry Steinbusch
10. Learned Helplessness in Mice
Hymie Anisman and Zul Merali
11. The Mouse Light-Dark Box Test
Martine Hascoet and Michel Bourin
12. Using the Elevated Plus Maze as a Bioassay to Assess the Effects of Naturally-Occurring, and Exogenously-Administered Compounds, to Influence Anxiety-Related Behaviors of Mice
Alicia A. Walf and Cheryl A. Frye
13. Novelty-Induced Hypophagia
Stephanie C. Dulawa
14. Acute and Chronic Social Defeat: Stress Protocols and Behavioral Testing
Alessandro Bartolumucci, Eberhard Fuchs, Jaap M. Koolhaas, and Frauke Ohl
15. Reduction of SubmissiveBehavior Model for Antidepressant Drug Testing in Mice
Ewa Malatynska, Albert Pinhasov, and Richard J. Knapp
16. Mice Models for the Manic Pole of Bipolar Disorder
Shlomit Flaisher-Grinberg and Haim Einat
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: March, 2012
Pages: 346
Weight: 735g
Availability: Available
Subcategories: General Issues, Neuroscience, Psychiatry
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