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MORE ABOUT THIS BOOK
Main description:
This volume presents cutting-edge techniques to design, fabricate and use compartmentalized microfluidic devices. Chapters encompass axon guidance and manipulation, compartmentalized devices for synapse manipulation, cell populations interaction either in physiological or pathological condition and compartmentalized devices for pharmacological research and drug discovery. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Authoritative and practical, Microfluidic and Compartmentalized Platforms for Neurobiological Research provides practical skills needed to fabricate, use microfluidics and compartmentalized platforms with neuronal cell cultures as well as the strengths of these exciting devices and their precious contribution in the field of Neuroscience.
Contents:
PART I: Designs and Methods
1. The Fabrication of Microfluidic Platforms with Pneumatically/Hydraulically Controlled PDMS Valves and their use in Neurobiological Research
Bryson M. Brewer, Donna J. Webb and Deyu Li
2. A Reliable Reversible Bonding Method for Perfused Microfluidic Devices
Paola Occhetta, Emilia Biffi, and Marco Rasponi
3. Bridging Two Cultures: Minimalistic Networks Prepared by Microfluidic Arraying, and Open Access Compartments for Electrophysiology
Jonathan West, Ngoc-Duy Dinh, Heike Hardelauf, Ya-Yu Chiang, Tracey A. Newman, Mariana Vargas-Caballero, Ayodeji A. Asuni, Katrin Deinhardt, and Martin Arundell
PART II: Axonal Guidance and Manipulation
4. Asymmetric Genetic Manipulation and Patch Clamp Recording of Neurons in a Microfluidic Chip
Prasanna Sakha, Cecilia Brunello, Joonas Heikkinen, Ville Jokinen, and Henri J. Huttunen
5. Development of a Compartmentalized Biochip for Axonal Isolation and Neuronal-Circuit Formation at the Single-Cell Level
Ting Huang, Tingfei Xi, Wan Qin, Bin Xu, Lina Wei, Lucas Schmidt, Nick Erdman, G. X. Guo, Mauris N Desilva, and Bruce Z. Gao
6. Campenot Cultures and Microfluidics Provide Complementary Platforms for Spatial Study of Dorsal Root Ganglia Neurons
Sara J. Fenstermacher, Maria F. Pazyra-Murphy, and Rosalind A. Segal
PART III: Manipulation Of Synapses
7. Development of Microfluidic Devices for the Manipulation of Neuronal Synapses
Anika Jain and Martha U. Gillette
8. Use of a 3 Compartment Microfluidic Device to Study Activity Dependent Synaptic Competition
Ainsley Coquinco and Max Cynader
PART IV: Interaction Of Different Cell Populations
9. Multi-Compartment Neuron-Glia Co-Culture Microsystem
Jaewon Park, Sunja Kim, Jianrong Li, and Arum Han
10. Compartmentalized Microfluidic Platforms as Tool of Choice to Study the Interaction Between Neurons and Osteoblasts
Estrela Neto, Diogo Paramos-De-Carvalho, Ana Henriques Lourenco, Paulo Aguiar, and Meriem Lamghari
11. A Novel In Vitro Primary Culture Model of the Lower Motor Neuron-Neuromuscular Junction Circuit
Katherine A Southam, Anna E King, Catherine A Blizzard, Graeme H Mccormack, and Tracey C Dickson
PART V: Pharmacological Manipulation and Screening
12. Compartmentalized Microfluidics for In Vitro Alzheimer's Disease Studies
Yufei Ren, Anja Kunze, Philippe Renaud
13. Selective Biochemical Manipulation of Twin Neuronal Networks on Micro Electrode Arrays By Giulia Regalia, Emilia Biffi, Marco Rasponi, and Alessandra Pedrocchi
14. Compartmentalized Synapse Microarray for High-Throughput Screening
Amol D. Jadhav, Wei Li, Zhen Xu, and Peng Shi
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: March, 2015
Pages: 220
Weight: 7035g
Availability: Available
Subcategories: Neuroscience
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