(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
In this volume, we hope to cover the malor techniques that are presently being used to analyze the actions of drugs used in psyc- atry. The contributors of the chapters are active researchers who have considerable practical experience with the techniques they are describing, and the emphasis in the chapters is on three types of psychiatric drugs, namely antidepressants, antipsychotics, and anxiolytics. The first chapter, by Curry and Yu, discusses protein binding of psychotropic drugs, with special reference to equilibrium ana- sis as the method of assessment and to lipophilicity correlations. Since many of the drugs used in treating psychiatric disorders are bound extensively to protein, this aspect is of great importance with regard to their therapeutic actions and toxicity, Basic mat- matical models, techniques for the study of protein binding, molecular aspects of protein binding, binding in relation to lipophilicity, indirect approaches to measurement of the fraction of drug bound, the function of protein binding, and tissue binding are among the topics discussed. Chapter 2, by Norman and B- rows, deals with the principles of isotope derivative assays and their applications to antidepressants and antipsychotics; extensive protocols are provided. The third chapter, by Cooper, deals with analysis by gas-liquid chromatography. Sample collection and storage, extraction procedures, column selection, use of internal standards, types of detectors, techniques of application, and - plications to specific drugs are among the topics discussed.
Contents:
Protein Binding of Psychotropic Drugs.- Isotope Derivative Assays for Psychotropic Drugs.- Gas-Liquid Chromatography of Antidepressant, Antipsychotic, and Benzodiazepine Drugs in Plasma and Tissues.- Gas Chromatographic- Mass Spectrometric Analysis of Antidepressants, Neuroleptics, and Benzodiazepines.- High-Performance Liquid Chromatographic Analysis of Antidepressants, Neuroleptics, and Benzodiazepines.- Principles of Radioreceptor Assays.- Application of Immunoassay Techniques in Psychopharmacology.- Drug Screening for Benzodiazepines, Antidepressants, and Neuroleptics.- In Vitro and Ex Vivo Neurochemical Screening Procedures for Antidepressants Neuroleptics Benzodiazepines.- Animal Models for Assessing Anxiolytic, Neuroleptic, and Antidepressant Drug Action.- High-Affinity Binding of Antidepressants to Platelets and Brain Tissues.- Structure-Activity Relationships at the Benzodiazepine Receptor.
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2013
Pages: 547
Weight: 822g
Availability: Available
Subcategories: Neuroscience
From the same series
Francisco Ciruela
Alon Korngreen
Judee K. Burgoon
David Walker
Nina Karpova
Gabriela K. Popescu
Jerome Y. Yager
Heather A. Bimonte-Nelson
Tetsuichiro Saito
Adalberto Merighi
Giselbert Hauptmann
Joost Verhaagen
Pierre L. Roubertoux
Kewal K. Jain
Wolfgang Blenau
Mario Tiberi
Vangelis Sakkalis
Benjamin R. Arenkiel
Jennie B. Leach
Johannes Hirrlinger
Alvaro Pascual-Leone
Theodore H. Schwartz
Eugenio F. Fornasiero
Antoine Triller
Fritjof Helmchen
Alan A. Boulton
Alan A. Boulton
Peter Thorn
Riccardo Brambilla
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Wolfgang Walz
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Wolfgang Walz
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Alan A. Boulton
Peter V. Nguyen
Stephane Marinesco
H. Aldskogius
Rolf Dermietzel
Paul M. Pilowsky
Giuseppe Di Giovanni
Ricardo Martinez Murillo
Nicole M. Avena
Klaus Ballanyi
Jean-Rene Martin
Bassem A. Hassan
Gerhard Grunder
Emilio Badoer
Allan V. Kalueff
Hideyuki Mukai
Todd D. Gould
Ole H. Petersen
Tommaso Fellin
Alexei Morozov
Yannis Karamanos
Alan A. Boulton
Stephen B. Dunnett
Stephen B. Dunnett
Todd D. Gould
Patricio O'Donnell
Ka Wan Li
Scott Q. Harper
Michael Aschner
James J. Chambers
Mary C. Olmstead
Illana Gozes
Peter Paul de Deyn
Robert P. Vertes
Andrea C. LeBlanc
Shlomo Seidman
Hugh C. Hemmings
Alan A. Boulton
Alan A. Boulton
Wolfgang Walz
Alan A. Boulton
Allan V. Kalueff
Allan V. Kalueff
Chao Ma
Jacob Raber
Ulrich Dirnagl
Iok-Hou Pang
Allan V. Kalueff
Kewal K. Jain
Prof. Alexei Verkhratsky
Todd D. Gould
Massimo Filippi
Scott C. Baraban
Illana Gozes
Wolfgang Walz