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Microelectrode Biosensors
Series: Neuromethods
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Main description:

For molecules that are not directly electroactive, it is necessary to modify a microelectrode by grafting polymeric or enzymatic membranes capable of translating a local concentration into an electrical current, which is a concept referred to as biosensing. In Microelectrode Biosensors, experts in the field cover the topic of electrochemical biosensor technology as applied to the neurosciences. The volume opens with a section addressing the specific issue of manufacturing biosensors that can be implanted in the central nervous system for neurotransmitter detection, and it then continues with sections on recent studies where biosensors have made a difference in bringing a new level of understanding of signaling mechanisms in neuroscience as well as recent developments in biosensor technology that have not yet been applied to implantable microelectrodes but may have great potential. Written for the Neuromethods series, this work contains the kind of detailed descriptions and implementation advice necessary to achieve successful results.

Focused and cutting-edge, Microelectrode Biosensors serves to inspire the wider neuroscience and physiology community to adopt these powerful methods in their own applications in order to move the field forward with the widespread advances that will most likely flow from the adoption of biosensing as part of the standard laboratory toolkit.


Contents:

Part I: Designs, Principles, and Methods

1. Microelectrode Designs for Oxidase-Based Biosensors

Stephane Marinesco and Olivier Frey

2. Microelectrode Array Fabrication and Optimization for Selective Neurochemical Detection

Kevin N. Hascup, Erin R. Hascup, O. Meagan Littrell, Jason M. Hinzman, Catherine E. Werner, Verda A. Davis, Jason J. Burmeister, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, and Greg A. Gerhardt

3. The Advantage of Microelectrode Technologies for Measurement in Delicate Biological Environments Such as Brain Tissue

Andrea Jaquins-Gerstl and Adrian C. Michael

4. Hexacyanoferrates as Mediators for Microelectrode Biosensors

Faming Tian and Nicholas Dale

5. Enzyme Immobilization on Microelectrode Biosensors

Natalia Vasylieva and Stephane Marinesco

6. Characterization of Polymer-Enzyme Composite Biosensors for Brain Monitoring In Vivo

Robert D. O'Neill

Part II: Case Studies

7. Monitoring Extracellular Glutamate in the Brain by Microdialysis and Microsensors

Si Qin, Miranda (van der Zeyden) Evering, Ngabi Wahono, Thomas I.F.H. Cremers, and Ben H.C. Westerink

8. Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays

Erin R. Hascup, Kevin N. Hascup, Pooja M. Talauliker, David A. Price, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, Alain Gratton, Ingrid Stroemberg, and Greg A. Gerhardt

9. Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors

Pierre Pernot, Caroline Maucler, and Stephane Marinesco

10. Measurement of Purine Release with Microelectrode Biosensors

Nicholas Dale

11. Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle

Raymond Cespuglio, Larissa Netchiporouk, and Nataliya Shram

12. Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors

Vinay Parikh and Martin Sarter

Part III: The Future?

13. Carbon Nanotubes-Based Microelectrode (Bio)sensors

Paloma Yanez-Sedeno, Lourdes Agui, and Jose M. Pingarron

14. Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy

Nicole Jaffrezic-Renault

15. Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins

Cassie Ho and Hua-Zhong Yu

16. Electrochemiluminescent Biosensors: Neuroscience Applications

Robert J. Forster and Tia E. Keyes

17. Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing

Samir Akhtar, Dan Fei, Farhan Mirza, Sergey Piletsky, Shenqi Wang, and Yi Ge

Si Qin, Miranda (van der Zeyden) Evering, Ngabi Wahono, Thomas I.F.H. Cremers, and Ben H.C. Westerink

8. Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays

Erin R. Hascup, Kevin N. Hascup, Pooja M. Talauliker, David A. Price, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, Alain Gratton, Ingrid Stroemberg, and Greg A. Gerhardt

9. Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors

Pierre Pernot, Caroline Maucler, and Stephane Marinesco

10. Measurement of Purine Release with Microelectrode Biosensors

Nicholas Dale

11. Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle

Raymond Cespuglio, Larissa Netchiporouk, and Nataliya Shram

12. Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors

Vinay Parikh and Martin Sarter

Part III: The Future?

13. Carbon Nanotubes-Based Microelectrode (Bio)sensors

Paloma Yanez-Sedeno, Lourdes Agui, and Jose M. Pingarron

14. Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy

Nicole Jaffrezic-Renault

15. Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins

Cassie Ho and Hua-Zhong Yu

16. Electrochemiluminescent Biosensors: Neuroscience Applications

Robert J. Forster and Tia E. Keyes

17. Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing

Samir Akhtar, Dan Fei, Farhan Mirza, Sergey Piletsky, Shenqi Wang, and Yi Ge


PRODUCT DETAILS

ISBN-13: 9781627033695
Publisher: Springer (Humana Press Inc.)
Publication date: April, 2013
Pages: 400
Weight: 9001g
Availability: Available
Subcategories: Neurology, Neuroscience
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