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Main description:
For molecules that are not directly electroactive, it is necessary to modify a microelectrode by grafting polymeric or enzymatic membranes capable of translating a local concentration into an electrical current, which is a concept referred to as biosensing. In Microelectrode Biosensors, experts in the field cover the topic of electrochemical biosensor technology as applied to the neurosciences. The volume opens with a section addressing the specific issue of manufacturing biosensors that can be implanted in the central nervous system for neurotransmitter detection, and it then continues with sections on recent studies where biosensors have made a difference in bringing a new level of understanding of signaling mechanisms in neuroscience as well as recent developments in biosensor technology that have not yet been applied to implantable microelectrodes but may have great potential. Written for the Neuromethods series, this work contains the kind of detailed descriptions and implementation advice necessary to achieve successful results.
Focused and cutting-edge, Microelectrode Biosensors serves to inspire the wider neuroscience and physiology community to adopt these powerful methods in their own applications in order to move the field forward with the widespread advances that will most likely flow from the adoption of biosensing as part of the standard laboratory toolkit.
Contents:
Part I: Designs, Principles, and Methods
1. Microelectrode Designs for Oxidase-Based Biosensors
Stephane Marinesco and Olivier Frey
2. Microelectrode Array Fabrication and Optimization for Selective Neurochemical Detection
Kevin N. Hascup, Erin R. Hascup, O. Meagan Littrell, Jason M. Hinzman, Catherine E. Werner, Verda A. Davis, Jason J. Burmeister, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, and Greg A. Gerhardt
3. The Advantage of Microelectrode Technologies for Measurement in Delicate Biological Environments Such as Brain Tissue
Andrea Jaquins-Gerstl and Adrian C. Michael
4. Hexacyanoferrates as Mediators for Microelectrode Biosensors
Faming Tian and Nicholas Dale
5. Enzyme Immobilization on Microelectrode Biosensors
Natalia Vasylieva and Stephane Marinesco
6. Characterization of Polymer-Enzyme Composite Biosensors for Brain Monitoring In Vivo
Robert D. O'Neill
Part II: Case Studies
7. Monitoring Extracellular Glutamate in the Brain by Microdialysis and Microsensors
Si Qin, Miranda (van der Zeyden) Evering, Ngabi Wahono, Thomas I.F.H. Cremers, and Ben H.C. Westerink
8. Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays
Erin R. Hascup, Kevin N. Hascup, Pooja M. Talauliker, David A. Price, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, Alain Gratton, Ingrid Stroemberg, and Greg A. Gerhardt
9. Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors
Pierre Pernot, Caroline Maucler, and Stephane Marinesco
10. Measurement of Purine Release with Microelectrode Biosensors
Nicholas Dale
11. Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle
Raymond Cespuglio, Larissa Netchiporouk, and Nataliya Shram
12. Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors
Vinay Parikh and Martin Sarter
Part III: The Future?
13. Carbon Nanotubes-Based Microelectrode (Bio)sensors
Paloma Yanez-Sedeno, Lourdes Agui, and Jose M. Pingarron
14. Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy
Nicole Jaffrezic-Renault
15. Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins
Cassie Ho and Hua-Zhong Yu
16. Electrochemiluminescent Biosensors: Neuroscience Applications
Robert J. Forster and Tia E. Keyes
17. Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing
Samir Akhtar, Dan Fei, Farhan Mirza, Sergey Piletsky, Shenqi Wang, and Yi Ge
Si Qin, Miranda (van der Zeyden) Evering, Ngabi Wahono, Thomas I.F.H. Cremers, and Ben H.C. Westerink
8. Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays
Erin R. Hascup, Kevin N. Hascup, Pooja M. Talauliker, David A. Price, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, Alain Gratton, Ingrid Stroemberg, and Greg A. Gerhardt
9. Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors
Pierre Pernot, Caroline Maucler, and Stephane Marinesco
10. Measurement of Purine Release with Microelectrode Biosensors
Nicholas Dale
11. Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle
Raymond Cespuglio, Larissa Netchiporouk, and Nataliya Shram
12. Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors
Vinay Parikh and Martin Sarter
Part III: The Future?
13. Carbon Nanotubes-Based Microelectrode (Bio)sensors
Paloma Yanez-Sedeno, Lourdes Agui, and Jose M. Pingarron
14. Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy
Nicole Jaffrezic-Renault
15. Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins
Cassie Ho and Hua-Zhong Yu
16. Electrochemiluminescent Biosensors: Neuroscience Applications
Robert J. Forster and Tia E. Keyes
17. Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing
Samir Akhtar, Dan Fei, Farhan Mirza, Sergey Piletsky, Shenqi Wang, and Yi Ge
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: April, 2013
Pages: 400
Weight: 9001g
Availability: Available
Subcategories: Neurology, Neuroscience
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