(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors' laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer's diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work. Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab.
Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.
Contents:
1. Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System
Padraig J. Mulcahy, Christopher Binny, Bartosz Muszynski, Evangelia Karyka, and Mimoun Azzouz
2. Lentiviral Vectors for Gene Delivery to the Nervous System
Ioanna Eleftheriadou and Nicholas D. Mazarakis
3. Gene Therapy for Parkinson's Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF)
Bas Blits, Deniz Kirik, Harald Petry, and Stephen Hermening
4. Gene Delivery and Gene Therapy for Alzheimer's Disease
Maya Woodbury, Tomomi Kiyota, and Tsuneya Ikezu
5. Gene Therapy for Huntington's Disease
Angela Wu, Dahna M. Fong, and Deborah Young
6. Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury
Xuenong Bo and Yi Zhang
7. Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors
Nitish D. Fagoe, Ruben Eggers, Joost Verhaagen, and Matthew R.J. Mason
8. Targeted Gene Therapy for Ischemic Stroke
Fanxia Shen and Hua Su
9. Adeno-Associated Viral Gene Therapy for Retinal Disorders
Samantha R. de Silva, Michelle E. McClements, Mark W. Hankins, and Robert E. MacLaren
10. Gene Therapy for Epilepsies
En-Ju D. Lin and Matthew J. During
11. AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement
Diane Golebiowski, Allison M. Bradbury, Churl-Su Kwon, Imramsjah M.J. van der Bom, Lorelei Stoica, Aime K. Johnson, Diane U. Wilson, Heather L. Gray-Edwards, Judith A. Hudson, Jacob A. Johnson, Ashley N. Randle, Brian K. Whitlock, James L. Sartin, Anna Luisa Kuhn, Matthew Gounis, Wael Asaad, Douglas R. Martin, and Miguel Sena-Esteves
12. Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice
Monir Shababi, Erkan Y. Osman, and Christian L. Lorson
13. Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain?
Isabel Martins and Isaura Tavares
14. Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models
John Lynes, Carl Koschmann, Mia Wibowo, Vandana Saxena, Marianela Candolfi, Mariela A. Moreno Ayala, Maria G. Castro, and Pedro R. Lowenstein
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: February, 2015
Pages: 360
Weight: 9335g
Availability: Available
Subcategories: Genetics, Neurology, Neuroscience
From the same series
