BOOKS BY CATEGORY
Your Account
Transforming Growth Factor-Beta in Cancer Therapy, Volume I
Basic and Clinical Biology
Price
Quantity
£199.50
(To see other currencies, click on price)
Paperback / softback
Add to basket  

£199.50
(To see other currencies, click on price)
Add to basket  

MORE ABOUT THIS BOOK

Main description:

Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF-~ in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF-~ was first isolated and characterized as a dimeric pep­ tide from both human and bovine sources (1-3), but the entire fieldofTGF-~ research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF-~ does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF-~can have disastrous consequences in almost all ofthese sites. Therefore, the present comprehensive review of so many aspects ofTGF-~ function is a most welcome attempt to bring together a huge body of experimental data that is of the utmost importance in the field of oncology.


Feature:

In-depth detail of basic concepts of TGF-ß in normal physiology and cancer pathobiology


Conveniently divided into three easy-to-follow parts


Companion volume details cancer treatments and therapies


Back cover:

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor-ß signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor-ß superfamily members in normal and tumor biology. Part III details transforming growth factor-ß in inflammation and fibrosis.


This volume’s companion, Cancer Treatment and Therapy, examines transforming growth factor-ß in several developing and advanced cancers and discusses methods of treatment and therapy. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.


Contents:

Transforming Growth Factor-ß in Cancer Therapy
Volume 1: Basic and Clinical Biology
Sonia B. Jakowlew, Ph.D., Editor
The Humana Press, Inc., Publisher
TABLE OF CONTENTS
In Memorium for Anita B. Roberts, PhD
John M. McPherson*

Preface
Sonia B. Jakowlew*

Foreward
Michael B. Sporn*

Contributors

Part I. Basic Concepts of TGF-ß Signaling in Normal Physiology and
Cancer Pathobiology

1 Component Hardware for Transforming Growth Factor-ß Signal
Transduction: TGF-ß Ligands, TGF-ß Receptors, and Smads
Sonia B. Jakowlew*

2 TGF-ß Signaling in Homeostasis and Cancer
Joan Seoane*

3 TGF-ß Availability: Latent TGF-ß and Latent TGF-ß Binding Proteins
Vesna Todorovic* and Daniel B. Rifkin

4 Biological Functions of Latent TGF-ß Binding Proteins and
Activation of TGF-ß Marko Hyytiäanen*, Katri Koli, and Jorma Keski-Oja

5 Regulators of Smad2/3 Transcription and Phosphorylation
Azeddine Atfi* and Marie-Francoise Bourgeade

6 Interaction of Smad4 and Embryonic Liver Fodrin (ELF)-ß-spectrin in
Hyperplasia, Neoplasia, and
Tumor Progression
Sang Soo Kim, Charles Shuman, and Lopa Mishra*

7 Regulation of Smad Activity by Phosphorylation
Fang Liu*

8 Nuclear Targeting of TGF-ß-activated Smads in Normal and Tumor Biology
Lan Xu*

9 Ski, Sno and Akt as Negative Regulators of Smad Activity: Balancing
Cell Death and Cell Survival
Erwan Le Scolan and Kunxin Luo*

10 Smurfs in TGF-ß Signaling and Regulation of Bone Homeostasis and
Cancer
Ying E. Zhang* and Motozo Yamashita

11 Involvement of KM23 Dynein Light Chains in TGF-ß Signaling
Qunyan Jin, Guofeng Gao, and Kathleen M. Mulder*

12 TGF-ß Signaling in Fibroblastic Cells and Oncogenes
Neil A. Bhowmick*

13 Mechanisms of TGF-ß-induced Apoptosis in Cancer Cells
Tae-Aug Kim* and Seong-Jin Kim

14 Mechanisms of Cell CycleRegulation by TGF-ß Disabled in Cancer
Leslie I. Gold* and Jon Lecanda

15 Proteasome in the Control of TGF-ß Signaling During Development and
Cancer
Arja Band and Marikki Laiho*

16 TGF-ß and Smad Signaling in Transcriptome Reprogramming During
Epithelial to Mesenchymal
Transition
Sylvie Thuault, Ulrich Valcourt, Marcin Kowanetz, and Aristidis
Moustakas*

17 Functional Interaction between MMPs and TGF-ß in Normal and Tumor
Tissue
Christina H. Stuelten*, Anita B. Roberts, and William G.
Stetler-Stevenson

18 Cooperation Between TGF-ß and Wnt Pathway Components in Regulating
Mesenchymal Stem Cell
Function
Irwin M. Liu, Steven H. Schilling, and Xiao-Fan Wang*

19 Interaction of Oncogenic Ras and TGF-ß1 Signaling in Cancer: Lessons
from the Multistage Skin
Carcinogenesis Model
Adam Glick*, Dong-Soon Bae, Xin Liu, and Kinnimulki Vijayachandra

Part II. TGF-ß Superfamily Members in Normal and Tumor Biology

20 Proteomics Analysis of TGFß Superfamily Members
Serhiy Souchelnytskyi*

21 Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally
Occurring Therapeutic Agent for Certain
Human Cancers
David T. MacLaughlin* and Patricia K. Donahoe

22 Activins, Inhibins and Bone Morphogenetic Proteins as Modulators of
Prostate Cancer Progression
Tetsu Hayashida, Vandana Gupta, Sam Thiagalinam, and Shyamala
Maheswaran*

23 Bone Morphogenic Proteins and Angiogenesis in Developing Tumors
George Berberian, Deepak Malhotra, and John E. Langenfeld*

24 Histone Methyltransferase and Smad Interactions in BMP Signaling
Jennifer E. Leader, M. Pilar Frontelo, and Robert J. Lechleider*

25 Endoglin (CD105): A Strong Candidate for Immunologic Targeting of
Tumor Neovasculature in Human
Malignancies
Ester Fonsatti and Michelle Maio*

26 Activins and Inhibins in Cancer Progression
Gail P. Risbridger* and


PRODUCT DETAILS

ISBN-13: 9781617377358
Publisher: Springer (Humana Press)
Publication date: November, 2010
Pages: 760
Weight: 1421g
Availability: POD
Subcategories: Oncology, Pharmacology
Related books
Publisher recommends
Related books
From the same series

CUSTOMER REVIEWS

Average Rating 

From the reviews:

"This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. … will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease … . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody’s Review Service, May, 2008)