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Transforming Growth Factor-Beta in Cancer Therapy, Volume I
Basic and Clinical Biology
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Main description:

Transforming Growth Factor- ss in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ss (TGF- ss) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume's companion, Cancer Treatment in Therapy, examines transforming growth factor- ss in other developing and advanced cancers and methods of treatment and therapy.


Contents:

Transforming Growth Factor-ss in Cancer Therapy
Volume 1: Basic and Clinical Biology
Sonia B. Jakowlew, Ph.D., Editor
The Humana Press, Inc., Publisher
TABLE OF CONTENTS
In Memorium for Anita B. Roberts, PhD
John M. McPherson*

Preface
Sonia B. Jakowlew*

Foreward
Michael B. Sporn*

Contributors

Part I. Basic Concepts of TGF-ss Signaling in Normal Physiology and
Cancer Pathobiology

1 Component Hardware for Transforming Growth Factor-ss Signal
Transduction: TGF-ss Ligands, TGF-ss Receptors, and Smads
Sonia B. Jakowlew*

2 TGF-ss Signaling in Homeostasis and Cancer
Joan Seoane*

3 TGF-ss Availability: Latent TGF-ss and Latent TGF-ss Binding Proteins
Vesna Todorovic* and Daniel B. Rifkin

4 Biological Functions of Latent TGF-ss Binding Proteins and
Activation of TGF-ss Marko Hyytiaanen*, Katri Koli, and Jorma Keski-Oja

5 Regulators of Smad2/3 Transcription and Phosphorylation
Azeddine Atfi* and Marie-Francoise Bourgeade

6 Interaction of Smad4 and Embryonic Liver Fodrin (ELF)-ss-spectrin in
Hyperplasia, Neoplasia, and
Tumor Progression
Sang Soo Kim, Charles Shuman, and Lopa Mishra*

7 Regulation of Smad Activity by Phosphorylation
Fang Liu*

8 Nuclear Targeting of TGF-ss-activated Smads in Normal and Tumor Biology
Lan Xu*

9 Ski, Sno and Akt as Negative Regulators of Smad Activity: Balancing
Cell Death and Cell Survival
Erwan Le Scolan and Kunxin Luo*

10 Smurfs in TGF-ss Signaling and Regulation of Bone Homeostasis and
Cancer
Ying E. Zhang* and Motozo Yamashita

11 Involvement of KM23 Dynein Light Chains in TGF-ss Signaling
Qunyan Jin, Guofeng Gao, and Kathleen M. Mulder*

12 TGF-ss Signaling in Fibroblastic Cells and Oncogenes
Neil A. Bhowmick*

13 Mechanisms of TGF-ss-induced Apoptosis in Cancer Cells
Tae-Aug Kim* and Seong-Jin Kim

14 Mechanisms of Cell CycleRegulation by TGF-ss Disabled in Cancer
Leslie I. Gold* and Jon Lecanda

15 Proteasome in the Control of TGF-ss Signaling During Development and
Cancer
Arja Band and Marikki Laiho*

16 TGF-ss and Smad Signaling in Transcriptome Reprogramming During
Epithelial to Mesenchymal
Transition
Sylvie Thuault, Ulrich Valcourt, Marcin Kowanetz, and Aristidis
Moustakas*

17 Functional Interaction between MMPs and TGF-ss in Normal and Tumor
Tissue
Christina H. Stuelten*, Anita B. Roberts, and William G.
Stetler-Stevenson

18 Cooperation Between TGF-ss and Wnt Pathway Components in Regulating
Mesenchymal Stem Cell
Function
Irwin M. Liu, Steven H. Schilling, and Xiao-Fan Wang*

19 Interaction of Oncogenic Ras and TGF-ss1 Signaling in Cancer: Lessons
from the Multistage Skin
Carcinogenesis Model
Adam Glick*, Dong-Soon Bae, Xin Liu, and Kinnimulki Vijayachandra

Part II. TGF-ss Superfamily Members in Normal and Tumor Biology

20 Proteomics Analysis of TGFss Superfamily Members
Serhiy Souchelnytskyi*

21 Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally
Occurring Therapeutic Agent for Certain
Human Cancers
David T. MacLaughlin* and Patricia K. Donahoe

22 Activins, Inhibins and Bone Morphogenetic Proteins as Modulators of
Prostate Cancer Progression
Tetsu Hayashida, Vandana Gupta, Sam Thiagalinam, and Shyamala
Maheswaran*

23 Bone Morphogenic Proteins and Angiogenesis in Developing Tumors
George Berberian, Deepak Malhotra, and John E. Langenfeld*

24 Histone Methyltransferase and Smad Interactions in BMP Signaling
Jennifer E. Leader, M. Pilar Frontelo, and Robert J. Lechleider*

25 Endoglin (CD105): A Strong Candidate for Immunologic Targeting of
Tumor Neovasculature in Human
Malignancies
Ester Fonsatti and Michelle Maio*

26 Activins and Inhibins in Cancer Progression
Gail P. Risbridger* and


PRODUCT DETAILS

ISBN-13: 9781617377358
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 760
Weight: 1421g
Availability: Available
Subcategories: Oncology, Pharmacology
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