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Cytokines in the Genesis and Treatment of Cancer
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Main description:

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume’s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress — both in animal models and humans — in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field.


Feature:

Explores the clearly demonstrated link between cytokines and cancer


Highlights potential treatment strategies that take advantage of utilizing cytokine and anti-cytokine therapies


Contributions from internationally distinguished investigators


Covers TNF, IL-2, IL-12, and Type I interferons, among others


Practically divided into four useful parts


Back cover:

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume’s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress — both in animal models and humans — in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field.


Contents:

Cytokines in the Genesis and Treatment of Cancer

Co-Editors: Michael A. Caligiuri and Michael T. Lotze

Introduction

1. Overview and Introduction to Cancer and Inflammation

Michael A. Caligiuri and Michael T. Lotze

Part I. Cytokines in the Genesis of Cancer

Infectious Agents, Cytokines and Cancer

2. Helicobacter Pylori

Richard M. Peek, Jr.

3. HTLV-1

Michael Lairmore and Lee Ratner

4. Herpes Viruses

Frank J. Jenkins and Heather R. Hensler

Cytokines and Carcinogenesis

5. TNF

Mark DeWitte, David J. Shealy, Marian Nakada, and G. Mark Anderson

6. TGF-Š

Alyssa R. Bonine, Brian K. Law and Harold L. Moses

7. Interleukin 1 (IL-1) Family of Cytokines

Michael T. Lotze

8. IL-4/13

Koji Kawakami and Raj Puri

9. IL-6 and Castleman's disease

Norihiro Nishimoto

10. Interleukin 10 (IL-10) Family of Cytokines

Shin-ichiro Fujii and Michael Lotze

11. Cytokines in Multiple Myeloma: Therapeutic Implications

Dharminder Chauhan, Teru Hideshima and Kenneth Anderson

12. Murine Cytokine Models and the Genesis of Cancer

Todd A. Fehniger, Megan A. Cooper, Michael A. Caligiuri

13. Experimental Models of Cytokines and Cancer Prevention

Mark J. Smyth, Erika Cretney, Shayna E.A. Street and Yoshihiro Hayakawa

Cytokines and Tumor Stroma/Metastasis

14. Cytokines in the Tumor Stroma

Michael C. Ostrowski

15. Cytokines and Angiogenesis in Tumors

Sharmila Roy-Chowdhury and Charles K. Brown

16. Chemokines and Receptor Expression in Tumor Progression

Paola Allavena, Federica Marchesi and Alberto Mantovani

17. The Biology of Cancer Cachexia: Role of TNF±

Denis Guttridge

Part II: Cytokines in The Treatment Of Cancer

18. IL-2

Kim Margolin and JoeClark

19. IL-12

Timothy E. Bael and Jared Gollob

20. The Type I Interferon Family

Stergios J. Moschos, Gregory B. Lesinski, William E. Carson, III, and John M. Kirkwood

21. Combination Cytokine Therapy

Seth Cohen and Howard Kaufman

22. Novel Strategies for Targeting Cytokine Administration

Paul M. Sondel, Jackie Hank, Mark Albertini and Stephen D. Gilles

23. Cytokines and Cancer Vaccines

Hideho Okada and Michael T. Lotze

24. Anti-cytokine Therapy

Miguel A. Villalona-Calero

25. Cytokines in the Supportive Care of Cancer

John A. Glaspy


PRODUCT DETAILS

ISBN-13: 9781617372032
Publisher: Springer (Humana Press)
Publication date: November, 2010
Pages: 504
Weight: 950g
Availability: POD
Subcategories: Oncology, Pharmacology
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CUSTOMER REVIEWS

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From the reviews:

"...brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer.  Together,, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field." -Anticancer Research

"This is a collection of papers from a large number of authors on the role of cytokines in the genesis of neoplastic diseases including metastatic spreads and the potential role in therapy. … Chronic cytokine production can contribute to the generation and progression of cancer. Mechanisms involved in this process are described in the many chapters of this volume. The book is highly recommended to all of those involved in the study of neoplastic diseases." (Julian L. Ambrus, The Journal of Medicine, March, 2008)

“This new volume in Humana’s series will be necessary reading for researchers, oncologists, pharmacologists, radiotherapists.” (Tumori, Vol. 93, 2007)