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Main description:
In Tumor Targeting in Cancer Therapy, Dr. Michel Page and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.
Contents:
Part I. A Review
The Current Status of Tumor Targeting: A Review
Tarunendu Ghose
Clinical Applications of Targeted Therapeutics
Tarunendu Ghose
Part II. Targeting Tumors with Drug Antibody Conjugates
Targeting the CD22 Receptor with RNA Damaging Agents
Huaitian Liu, Dianne L. Newton, Hans J. Hansen, Stanislaw M. Mikulski, David M. Goldenberg, Edward A. Sausville, and Susanna M. Rybak
The Development of Liposomes for Enhanced Delivery of Chemotherapeutics to Tumors
Paul Tardi, Ludger Ickenstein, Marcel Bally, and Lawrence Mayer
Overcoming Multiple Drug Resistance with Anti-Pgp Carrier
Brigitte Page and Michel Page
Targeting with Transferrin, Mandip Singh
Synthesis and Evaluation of Paclitaxel Immunoconjugate with Antitumor Activity In Vitro
Jairo Jaime Correa and Michel Page
The Use of Drug-Monoclonal Antibody Conjugates for the Treatment of Cancer
Geoffrey A. Pietersz and Ian F. C. McKenzie
Part III. Targeting Tumors with Antibodies
Targeting Vascular Endothelium with Antibodies
Przemek Twardowski and Kim Margolin
Targeting B-Cell Non-Hodgkin's Lymphoma with Monoclonal Antibodies
Christian Buske and W. Hiddemann
From Bench to Bedside: Development of Rituximab (Rituxan (R)), A Monoclonal Antibody for the Therapy of Non-Hodgkin's Lymphoma
Roland Newman
Mylotarg: The First Antibody-Targeted Chemotherapy Agent
Philip R. Hamann and Mark S. Berger
Part IV. Targeting Tumors with Radioimmunoconjugates
188Rhenium-Labeled Trisuccin-DCh2HuCC49 as a Radioimmunotherapy Model in Nude Mice
Ahmad Safavy and Donald J. Buchsbaum
Part V. Targeting Tumors with Immunotoxins
General Approach for Targeting Toxins
Manish Monga, Richard A. Messman, and Edward A. Sausville
Antibody-Toxin Conjugates: Chemistry of Couplingand Purification
Silvana Canevari, Maria Ines Colnaghi, Luigi Cattel, and Franco Dosio
Shiga-Like Toxins as Targeted Anticancer Agents
Paul LaPointe and Jean Gariepy
Part VI. Targeting Tumors with Antibody-Enzyme Conjugates (ADEPT)
Antibody-Directed Enzyme Prodrug Therapy with Carboxypeptidase G2: Clinical Studies
Kenneth D. Bagshawe
Part VII. Photodynamic Therapy
Photodynamic Therapy: Targeting Cancer Cells with Photosensitizer-Bioconjugates
Cynthia M. Allen, Wesley M. Sharman, and Johan E. van Lier
Tumor Targeting Using PEG-m-THPC for Photodynamic Therapy in a Rat Ovarian-Cancer Model
Rene Hornung
Part VIII. Targeting Tumors with Magnetic Drugs
Targeting Tumors with Magnetic Drugs
Andreas S. Lubbe, Christian Bergemann, and Christoph Alexiou
Part IX. Principles and Techniques in Targeting
Internalization of Antibodies
Jairo Jaime Correa
Bioconjugation and Biodistribution
Francesco M. Veronese and Paulo Caliceti
Principles of Antitumor Targeting of Cytotoxic Drugs
Gene M. Dubowchik
Targeting by Antibody or Ligand: Which Is Better?
Douglas A. Lapp
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 474
Weight: 890g
Availability: Available
Subcategories: Pharmacology
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