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MORE ABOUT THIS BOOK
Main description:
This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed 'amyloid'. Examples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimer's disease-related dementia and Parkinson's disease, as well as other less prevalent conditions like Huntington's disease, cerebral amyloid angiopathy and the transmissible prion disorders. A disease-modifying therapeutic agent is still lacking for all these diseases, and there are no approved therapies that target amyloid formation directly. Nevertheless, a large and complex group of natural aromatic compounds known as polyphenols are rapidly emerging as potentially potent anti-amyloidogenic agents.
This book collectively presents a considerable body of experimental and epidemiological evidence from peer-reviewed scientific publications that support a role for natural compounds and herbal extracts in the chemoprevention and therapy of amyloidogenic disorders.
Each contribution is written by scientific experts in the relevant field; chapters are devoted to Mediterranean diet and olive oil phenols, traditional Chinese medicine, herbal extracts, polyphenols (with a particular emphasis on epigallocatechin-3-gallate) and bi-flavonoids, amongst others.
The topic of this book is relevant to a wide audience, from academia and university students in the biological and chemical sciences, to physicians and allied health professionals, as well as people working in the nutraceutical industry.
Contents:
Preface
1. Olive Oil Phenols as Promising Multi-targeting Agents against Alzheimer's disease; Stefania Rigacci
2. Alzheimer's disease, Drosophila melanogaster and Polyphenols; Marlene Jimenez Del Rio and Carlos Velez-Pardo
3. Biflavonoids as Potential Small Molecule Therapeutics for Alzheimer's disease; Arjun Thapa and Eva Chi
4. Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis; Masahito Yamada, Kenjiro Ono, Tsuyoshi Hamaguchi and Moeko Noguchi-Shinohara
5. Brain Food for Alzheimer-free Ageing: Focus on Herbal Medicines; Helmut M. Hugel
6. Tea Polyphenols in Parkinson's disease; Mario Caruana and Neville Vassallo
7. The Effect of (-)-Epigallo-catechin-(3)-gallate on Amyloidogenic Proteins Suggests a Common Mechanism; Kathrin Andrich and Jan Bieschke
PRODUCT DETAILS
Publisher: Springer (Springer International Publishing AG)
Publication date: July, 2015
Pages: 230
Weight: 4758g
Availability: Available
Subcategories: Biochemistry, Epidemiology, Neurology, Pharmacology
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