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MORE ABOUT THIS BOOK
Main description:
This book is derived from contributions to the Second International Workshop on Mechanisms in Cell-Mediated Cytotoxicity, held in Annopolis, Maryland, June 10-13, 1984. This workshop was organized by an international committee of immunologists interested in lymphocyte cytotoxic mechanisms (G. Berke, W.R. Clark, P. Golstein, M. Hanna, P. Henkart, R. Herberman, H.R. MacDonald, E. Martz, and C. Nathan), who strove to invite participants who have made major contributions to this field. The Workshop was a follow-up to the highly successful 1981 Workshop, whose proceedings Workshop were published by Plenum as Mechanisms in Cell-Mediated Cytotoxicity, edited by W.R. Clark and P. Golstein. That volume has been much appreciated by researchers and students since it contains accounts of most of the current approaches to understanding cytotoxic lymphocyte mechanisms all in one volume. The present book may be viewed as a follow-up to the first one, and in our opinion fairly summarizes the varying current viewpoints on lymphocyte cytotoxic mechanism. It should be noted that the discussions have been transcribed directly by us, and the participants have not had an opportunity to edit their remarks. We have tried to maintain some of the style of the actual discussion in these transcripts. In some cases technical problems prevented usable transcriptions from being made, and hence not all of the actual discussion at the workshop is reproduced here.
Contents:
I. Non-Lymphocyte Cytotoxic Mechanisms.- Formation Of Protein Channels In Target Membranes.- Discussion.- Ige-Dependent Platelet Cytotoxicity Against Helminths.- Discussion.- Killing of Gram-Negative Bacteria by Neutrophils: Role of 02-Independent System in Intracellular Killing and Evidence Of 02-Dependent Extracellular Killing.- Discussion.- Abberant Oxygen Metabolism in Neoplastic Cells Injured by Cytotoxic Macrophages.- The Cell Biology of Tumor Cell Capture by Activated Macrophages.- Discussion.- Destructive Interactions Between Murine Macrophages, Tumor Cells, and Antibodies of the Igg2A Isotype.- II. Mechanistic Features Shared by CTL and NK Cells.- Reorientation of the Golgi Apparatus and the Microtubule Organizing Center: is it a Means to Polarize Cell-Mediated Cytotoxicity?.- Discussion.- Cytolytic T Cell Granules: Biochemical Properties and Functional Specificity.- Discussion.- The Role of Cytoplasmic Granules in Cytotoxicity by Large Granular Lymphocytes and Cytotoxic T Lymphocytes.- Discussion.- A Unified Theory for the Mechanism of the Lethal Hit by Cytotoxic T Lymphocytes (CTL) and Natural Killer (NK) Cells as Defined by Antisera Capable of Blocking the Lethal Hit Stage of Cytotoxicity.- Discussion.- Human Nk Resistant Tumor Cell Lysis is Effected by IL-2 Activated Killer Cells.- Discussion.- III. NK Cell Mediated Cytotoxicity.- Biochemical Characterization of Natural Killer Cytotoxic Factors.- Both NK Sensitive and Resistant Mycoplasma Free Cell Lines Stimulate Release of NKCF.- Discussion.- Studies of Human Natural Killer Cytotoxic Factor (NKCF): Characterization and Anlaysis of its Mode of Action.- Discussion.- An Investigation of the Role of Soluble Cytotoxic Factors and Reactive Oxygen Intermediates in Lysis by NK Cells.- Discussion.- Analysis of Sequential Substages Of the Natural Killer Cell Lethal Hit.- Discussion.- The Lipoxygenase Pathway in the Human Nk Cell System.- A Serine Proteinase as a "Trigger" For Human Natural Killer Lymphocyte-Mediated Cytolysis.- The Mechanism of Leukoregulin Enhancement of Target Cell Susceptibility to NK Cell Mediated Cytotoxicity in Humans.- IV. The Role of Membrane Components in CTL Function.- Lymphocyte Function-Associated Antigens: Regulation of Lymphocyte Adhesions in Vitro and Immunity in Vivo.- Discussion.- The Function of LFA-1 in Cell-Mediated Killing and Adhesion: Studies on Heritable LFA-1, Mac-1 Deficiency and on Lymphoid Cell Self-Aggregation.- Discussion.- Functional Interactions of LFA-1, T8 and Alloantigen Surface Structures in T-Cell Mediated Cytotoxicity.- Discussion.- Requirement for LYT-2/3 Molecules on Allospecific Cytolytic T Lymphocyte Clones is Dependent Upon Target Cell Antigen Density.- Discussion.- Functional Relationships of LYT-2 and LYT-3 Expression and T Cell Cytototoxicity: A New Model System.- The Role of the T3 Molecular Complex on Human T Lymphocyte-Mediated Cytotoxicity.- Discussion.- The Plasma Membrane 'Skeleton' of Tumor and Lymphoid Cells: a Role in Cell Lysis?.- p215 And p24: Two Membrane-Associated Proteins Expressed on Cloned Cytolytic T-Cells but Not on Cloned Helper T-Cells.- Mechansim of T-Dependent Cytotoxicity: Role of Papain-Sensitive Non CLASS I MHC Target Molecules and Expression of Target Antigen for Cytotoxicity.- Cell Contact Proteins in Antigen-Specific and Antigen-Nonspecific Cellular Cytotoxicity.- Discussion.- V. Post-Binding Events in the Cytotoxic Process.- Evidence for the Molecular Dissociation of Binding and Post-Binding Functions in Cytotoxic Lymphocytes.- Discussion.- Immune Cytolysis Viewed as a Stimulatory Process of the Target.- Discussion.- DNA Fragmentation in Targets of CTL: an Example of Programmed Cell Death in the Immune System.- Discussion.- Mechanism of Rapid Tumor Lysis by Human Adcc: Mediation by Monoclonal Antibodies and Fragmentation of Target Cell DNA.- Discussion.- Cell Surface Thiols, Methylation, and Complementlike Components are Involved in the Early Events of CML Whereas Proteases Participate in the Later,CaDependent Events.- Antigen/Mitogen Induced Cytolytic Activity and IL-2 Secretion in Memory-Like CTL Hybridomas.- Discussion.- Quantitative Models for The Kinetics of Cell-Mediated Cytotoxicity at the Single Cell Level.- Author Index.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: November, 2012
Pages: None
Weight: 1104g
Availability: Available
Subcategories: Immunology
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