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Main description:
Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications.
Contents:
Superoxide Dismutase.- Extracellular Superoxide Dismutase: Distribution in the Body and Therapeutic Applications.- Targeting SOD by Gene and Protein Engineering and Inhibition of Oxidative Stress in Various Diseases.- The Role of Superoxide Dismutase (SOD) in Preventing Postischemic Spinal Cord Injury.- SOD in Rat Models of Shock and Organ Failure.- The Protective Role of Superoxide Dismutase During Activation of Ribonucleotide Reductase.- Effect of Superoxide Dismutase on the Autoxidation of Hydroquinones Formed during DT-Diaphorase Catalysis and Glutathione Nucleophilic Addition.- Copper Complexes And Other Sod Mimicks.- Superoxide Scavengers and SOD or SOD Mimicks.- Reactivity of Active Centre Analogues of Cu2Zn2 Superoxi de Di smutase.- SOD Mimicking Properties of Copper(II) Complexes: Health Side Effects.- Radiation Recovery Agents: Cu(II), Mn(II), Zn(II) or Fe(III) 3,5-Diisopropylsalicylate Complexes Facilitate Recovery from Ionizing Radiation Induced Radical Medi ated Ti ssue Damage.- Effects of Glycyl-Histidyl-Lysyt Chelated Cu(II) on Ferritin Dependent Lipid Peroxidation.- SOD-Like Activity of 5-Membered Ring Nitroxide Spin Labels.- Antioxidant Vitamins.- Vitamin E in Biological Systems.- The Role of Vitamine E in the Hepatotoxicity by Glutathione Depleting Agents.- Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E free radical reductase.- Quenching of Singlet Oxygen by Tocopherols.- Antioxidant Properties of Vitamin E and Membrane Permeability in Human Fibroblast Cultures.- Vitamin E and Tumor Growth.- Abnormal Susceptibility to Lipid Peroxidation of Plasma LDL and its Prevention by Alpha-Tocopherol during Experimental Cholestasis in the Rat.- The Role of Oxidative Modification and Antioxidants in LDL Metabolism and Atherosclerosis.- Effects of Vitamin E Treatment in Cholestatic Children.- Efficacy of Vitamin E as a Drug in Inflammatory Joint Diseases.- Vitamin E and Correlated Antioxidants: A ? Radiolysis Study.- Ascorbate: The Most Effective Antioxidant in Human Plasma.- Other Natural And Synthetic Antioxidants.- Radical Chemistry of Flavonoid Antioxidants.- Scavenging Effects of Aspalathus Linealis (Rooibos Tea) on Active Oxygen Species.- Selenium and Oxidant Injury in Patients with Cystic Fibrosis.- Selenium and Glutathione Peroxidase Activity in Diploid Human Fibroblasts. Their Effects against H2O2 or UVB Induced Toxicity.- Selenium Therapy in Down Syndrome. A Theory and a Clinical Trial.- Protection by Seleno-Organic Compound, Ebselen, against Acute Gastric Mucosal Injury Induced by Ischemia Reperfusion in Rats.- Biological Activities and Clinical Potential of Ebselen.- Glutathione Level in Mouse Brain after Testosterone Administration..- Prostaglandins, Glutathione Metabolism and Lipid Peroxidation in Relation to Inflammation in Bovine Mastitis.- Sulfur Containing Compounds as Antioxidants.- Zinc, a Redox-Inactive Metal Provides a Novel Approach for Protection against Metal-Mediated Free Radical Induced Injury: Study of Paraquat Toxicity in E.coli.- Antioxidative Action of Zinc-Carnosine Compound Z-103.- High Molecular Weight Forms of Deferoxamine: Novel Therapeutic Agents for Treatment of Iron Mediated Tissue Injury.- Oxygen Toxicity: Role of Hydrogen Peroxide and Iron.- Antioxidant Properties of an Antiischaemic Agent: Trimetazidine.- Oxidative Damage in Chronic Heart Failure: Protection by Captopril through Free Radical Scavenging?.- Free Radical Scavenging Capacity and Anti-Inflammatory Activity of CBS-113 A.- Mechanism, whereby Different Antioxidants and Lipoxy- genase Pathway Inhibitors Suppress IL2 Synthesis.- Reactive Oxygen Species Released by Human Blood neutrophils from Pi roxi cam-Treated Healthy Subjects.- Antioxidative properties of met- and leu-Enkephalin.- Platelet-Activating Factor Amplifies Tumour Necrosis Factor-Induced Superoxide Generation by Human Neut rophi Is.- Comparison of Antioxidant and Prooxidant Activity of Various Synthetic Antioxidants.- Radiation And Chemotherapy.- Antioxidant Effects in Radioprotection.- Nuclear Glutathione Transferases which Detoxify Irradiated DNA.- Urinary Biomarkers in Radiation Therapy of Cancer.- Redox Parameters Associated to Cytotoxic and Antitumor Activities in the Series of Antitumor Drugs Ellipticines and Derivatives.- Peroxidase Induced Metabolism and Lipid Peroxide Scavenging by Antitumor Agents.- Reduction of Toxicity and Increase of Antitumor Effect of Adriamycin by N-Acyl Dehydroalanines: a New Family of Free Radical Scavengers.- Inhibition of Bleomycin-Induced Toxic Effects by Anti- Oxidants in Human Malignant Melanoma Cells.- Are Oxygen Radicals Responsible for the Acute Cardio- Toxicity of Doxorubicin?.- Influence of Selenium on Lipid Peroxidation and Cardiac Functions in Chronically Adriamycin-Treated Rats.- Ischemia-Reperfusion Injury.- Improvement of Ischemic and Postischimic Mitochondrial Function by Deferrioxamine: the Role of Iron.- Allopurinol in Ischemia-Reperfusion Injury of the Heart.- Direct Measurement of Free Radical Generation in Isolated Rat Heart by Electron Paramagnetic Resonance Spectroscopy: Effect of Trimetazidine.- Effect of a 5 Day Trimetazidine Pretreatment in a Model of Ischemic and Reperfused Isolated Rat Heart: Spin Trapping Experiments.- Antilipoperoxidant Effect of Trimetazidine in Postischemic Acute Renal Failure in the Rat.- Reperfusion Injury and Renal Metabolism: the Temporal Relationship between Oxidative Stress and Functional Change.- Iron Redistribution and Lipid Peroxidation in the Cold Ischemi c Kidney.- Evidence that Calcium Mediates Free Radical Damage through Activation of Phospholipase A2during Cold Storage of the Rabbit Kidney.- Ischemia-Reperfusion Injury and Free Radical Involvement in Gastric Mucosal Disorders.- Zinc-Carnosine Chelate Compound (Z-103) Attenuates Acute Gastric Mucosal Injury Induced by Ischemia Reperfusion in Rats.- Role of Xanthine-Xanthine Oxidase Systems and Polymorpho Nuclear Leukocytes in Lipid Peroxidation in Compound 48/80-Induced Gastric Mucosal Injury in Rats.- Effect of the Platelet-Activating Factor (PAF) Antagonists, Bn 52021, on Free Radical-Induced Intestinal Ischemia Reperfusion Damage in the Rat.- Other Diseases.- Antioxidant Therapy in Hematological Disorders.- The Adult Respiratory Distress Syndrome (ARDS) and Oxidative Stress: Therapeutic Implications.- Antioxidant Activity in Fetal and Neonatal Lung.- Pro-and Anti-oxidant Factors in Rat Lung Cytosol.- Oxidants, Joint Inflammation and Anti-Inflammatory Strategies.- Antioxidant Therapy in Neurological Disorders.- Free Radicals and Trials of Antioxidant Therapy in Muscle Diseases..- Parkinson's Disease and Alzheimer's Disease: Neuro- Degenerative Disorders due to Brain Antioxidant System Deficiency?.- Oxidative Stress, Poly(ADP)Ribosylation and Aging: invitroStudies on Lymphocytes from Normal and Down's Syndrome Subjects of Different Age and from Patients with Alzheimer's Dementia.- Protein Oxidation and Proteolytic Degradation: General Aspects and Relationship to Cataract Formation.- Free Radicals and Antioxidants in the Pathogenesis of Eye Diseases.- Singlet Oxygen-Induced Damage to Rat Lenses in vitro, Protection by Anisyldithiolthione.- Dermatologic Antioxidant Therapy May be Warranted to Prevent Ultraviolet Induced Skin Damage.- Antioxidant and Prooxidant Effects of the Antipsoriatic Compound Anthralin in Skin and Subcellular Fractions.- Antioxidant Treatment in Experimental Thermal Injury.- Production of Superoxide Anion by Glycated Proteins: Involvement in Complications of Diabetes Mellitus.- Rationale for Antioxidant Therapy in Pancreatitis and Cystic Fibrosis.- Lipid peroxidation Levels and Antioxidant Activities of Blood Plasma in Parturients and New-Born Infants after Normal Delivery.- Attendees.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: April, 2012
Pages: 608
Weight: 1149g
Availability: Available
Subcategories: Biochemistry, Nuclear Medicine, Pharmacology, Radiology
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