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Main description:
The International Workshop - Conference on Atherosclerosis was held at the University of Western Ontario, London, Ontario, Canada, September 1 - 3, 1975. This book does not represent in a strict sense the entire proceedings of the above Workshop - Conference, but does reflect largely the format and the essential content of the scientific sessions. Thus, each of the three Sections of the book is comprised of the summarized presentations either at the Plenary Sessions (Section I), Proffered Papers (Section II) or Workshops (Section III). Section I comprises all the presentations of the Plenary Session on September 1 and the first three presentations at the Plenary Session on the last day of the Conference (September 3). The remaining two addresses of the latter Session (Resume of Workshop - Conference and Closing Remarks) follow the Section III at the end of the book. Sections II and III are subdivided into Chapters which correspond to the individual Sessions of Proffered Papers and Workshops, respectively. To facilitate the orientation, particularly for those who attended the Workshop - Conference, a Summary Table of all Sessions of Proffered Papers designated as Chapters in this book, precedes Section II, and a similar Summary Table of Workshops, also designated as Chapters, precedes Section III. The Tables include, in addition, the names of both Chairmen of each Session. The Chairmen whose names do not appear on either Summary Table are those who chaired the two Plenary Sessions, i. e.
Contents:
Welcoming Address.- A. Welcoming Address.- B. Introduction.- C. Section I (Plenary Sessions).- 1. Highlights of Current Research in Atherosclerosis.- 2. Plasma Lipoproteins: Recent Developments.- 3. Arterial Endothelium and Its Potentials.- 4. The Coronary Drug Project - Findings with Regard to Estrogen, Dextrothyroxine, Clofibrate and Niacin.- 5. The Place of the Aorto-Coronary By-Pass Surgery in the Treatment of Ischemic Heart Disease.- 6. Current Concepts of Coronary Thrombosis as Related to Atherosclerosis and Myocardial Infarction.- 7. Effect of Drugs on Platelets and Complications of Vascular Disease.- D. Section II (Proffered Papers) - Chapter 1 - Clinical Epidemiology.- 1. Hyperlipoproteinemia in Chronic Hemodialysis Patients and Long-Term Renal Transplant Recipients.- 2. Cholesterol Tracking; Prediction Over Time of Serum Cholesterol in Evans County, Ga..- 3. Coronary Heart Disease Profile in Australian Men and Some Factors Influencing Survival.- 4. Exercise ST Segment Depressions in Asymptomatic Hyperlipoproteinaemia and its Relation to Various Lipoprotein Classes.- 5. Atherosclerotic Cardiovascular Mortality in the Island of Crete Study.- 2 - Myocardial Infarction.- 1. Non-Obstructive Mural Coronary Thrombosis in Sudden Death.- 2. Improved Biochemical Detection of Myocardial Ischemic Injury.- 3. Myocardial Perfusion Assessed by Direct Coronary Arterial Injection of Radiolabelled Particles.- 4. Controlled Trial of a Cardiac Ambulance Service Manned by Ambulance Personnel.- 5. The Heparin Neutralizing Activity Test in the Diagnosis of Acute Myocardial Infarction (MI).- 3 - Fate of Lipoproteins.- 1. Chylomicron Remnant Particle Formation In Vivo in Hepatectomized Rat.- 2. Use of Esterified Retinol to Trace the Degradation of Chylomicrons in Cholesterol-Fed Rabbits.- 3. Postheparin Plasma Lipoprotein Lipase and Hepatic Lipase in Normal Human Subjects: Relationship to Age, Sex and Triglyceride Metabolism.- 4. Lipoprotein Lipase and Hepatic Lipase Activity in Post-heparin Plasma of Patients with Hypertriglyceridemia.- 5. Autoimmune Hyperlipidemia in the Nephrotic Syndrome.- 4 - Aortic Glycosaminoglycans, Gangliosides and Glycolysis.- 1. Further Studies on Glycosaminoglycan - Lipoprotein Interactions.- 2. Interactions of Glycosaminglycans with Collagen and Elastin in Bovine Aorta.- 3. Structural Characterization of Gangliosides from Normal and Atherosclerotic Human Thoracic Aortas.- 4. Studies on the Role of Increased Arterial Glycolysis in Atherogenesis.- 5. Influence of Glycosaminoglycan Content on Diffusive Transport of Calcium and Water Across the In Vitro Artery Wall.- 5 - Hemodynamics.- 1. Interrelationship of Hypertension and Atherosclerosis in a Subhuman Primate Model.- 2. Altered Renal Flow in the Localization of Sudanophilic Lesion in Rabbit Aortas.- 3. The Hemodynamic Basis of Atherosclerosis.- 4. City-Wide Screening for Detection of Hypertension.- 6 - Hyperlipidemia in Man and Treatment.- 1. Lipid-Protein Proportionate and Disproportionate Varieties of Lipoproteinemia.- 2. Metabolic Effects of the Bile Acid Sequestrant Polidexide (SeeholexR) in Man.- 3. Colestipol Hydrochloride, a New Hypolipidemic Drug: A Two-Year Study - Summary.- 4. Dietary Influence on Molecular Distribution of Serum Lipoproteins in Subjects with Proven Coronary Artery Disease.- 5. The Educational Diagnosis in Nutrition Counseling for Serum Cholesterol Reduction.- 7 - Atherosclerosis and Childhood.- 1. Metabolic Response to Intralipid Infusions in the Neonatal Period.- 2. Serum Cholesterol and Triglyceride Levels in Children from a Biracial Community - The Bogalusa Heart Study.- 3. Identification and Management of the Child at Risk for Atherosclerosis.- 4. A Study of the Dose-Effect Relationship of Cholestyramine in Children with Familial Hypercholesterolemia.- 5. Hyperlipidaemia and Weight Gain After Maturity.- 8 - Fibrinolytic Activity; Platelets.- 1. Associations Between Fibrinolytic Activity and Other Variables in an Industrial Population.- 2. Effects of Aspirin and Sulfinpyrazone on Platelet Prostaglandin Synthesis.- 3. Increase in Platelet Factor 4-Like Activity in the Initial Stages of Atherosclerosis in Pigeons.- 4. Inhibition of Platelet Adherence to Damaged Vessel Wall by Drugs.- 5. Experimental Modification of Platelet Survival.- 9 - Permeability; Tissue Culture.- 1. Hyperreactive Arterial Endothelial Cells in Atherogenesis - Effect of Smooth Muscle Relaxants.- 2. The Effect of Moderate Increases in Serum Cholesterol on the Blood-Artery Cholesterol Transfer Barrier.- 3. Cholesterol Exchange: Evidence for a Role in Arterial Cholesterol Accumulation.- 4. Cholesterol Metabolism in Human Endothelial Cells in Culture.- 5. Effect of Lipoprotein on In Vitro Synthesis of DNA in Aortic Tissue.- 10 - Experimental Models of Hyperlipidemia.- 1. Comparison of Age Related Alterations in Arterial Sterol Accumulation, Blood Pressure and Cholesterol Balance in Spontaneously Atherosclerosis-Susceptible and Atherosclerosis-Resistant Pigeons.- 2. Hereditary Hyperlipidemia in Chickens - Model for Study of Toxic Oxidation Products Found in Significant Amounts in U.S.P. Cholesterol, Powdered Eggs and Milk.- 3. A Comparative Study of the Effect of Dietary Cholesterol on Plasma Lipoproteins in Nonhuman Primates.- 4. Lipoproteins and the In Vitro Study of Cholesterol Metabolism in Gerbils.- 5. A Circulating Inhibitor of Post-Heparin Plasma Lipolysis in the Type IV-V Hyperlipoproteinemia Induced in Green Lymphoma-Bearing Hamsters.- 11 - Experimental Hypercholesterolemia.- 1. Turnover of Cholesterol in Aorta of Rabbits Previously Fed a Cholesterol-Enriched Diet.- 2. Turnover and Aortic Uptake of Very Low Density Lipoproteins (VLDL) from Hypercholesteremic Rabbits: Effect of Metformin.- 3. Increased Oxygen Consumption in Cholesterol-Fed Rabbits.- 4. Effects of Dietary Proteins and Amino Acids on the Plasma Cholesterol Concentrations of Rabbits Fed Cholesterol-Free Diets.- 5. Serum and Aortic Lipids of Rats Fed Long-Term Equilibrate Diets Containing Various Alimentary Fats.- 12 - Lipid Composition and Metabolism in Man.- 1. The Characteristics of Human Plasma Lipoprotein Metabolism: Influence of Low Caloric Diet on Hyperlipidemia.- 2. Fatty Acid Composition of Adipose Tissue in Patients with Myocardial Infarction Compared with Subjects Free of Coronary Heart Disease.- 3. Cholesterol Synthesis and Uptake by Fat Cells in Familial Hypercholesterolemia.- 4. Effects of Caloric Restriction on Cholesterol Metabolism in Hyperlipemic Obese Subjects.- 5. Relationships between Plasma Lipoprotein Cholesterol Concentrations and the Pool Size and Metabolism of Cholesterol in Man.- 13 - Metabolic Control in Animal Tissues.- 1. Injected 7-0X0 Cholesterol and Plant Sterol Derivatives and Hepatic Cholesterogenesis.- 2. The Effects of Fasting and Refeeding on In Vitro Lipogenesis and Glycogen Synthesis From U-14C-Glucose in the Rat Aorta.- 3. Cholesterol Ester: Lysolecithin Acyltransferase Activity of the Aorta.- 4. Significance of Lipoprotein Lipase in Rat Skeletal Muscle.- 5. Decreased Cardiac Glycogen Following Phenformin Injection in Hyperglycemic, Hyperinsulinemic Anaesthetized Rats.- 14 - Experimental Lesions - Morphology.- 1. Comparative Ultrastructure of Primate Fatty Streaks.- 2. Spontaneous Arterial Lesions in Normal Pigs and Pigs with Von Willebrand's Disease.- 3. Injury Induced Atherosclerosis; Is Injury or Thrombosis Responsible for Progression of Lesions?.- 4. The Effect of Hypercholesterolemia on the Response Patterns After Different Types of Defined Mechanical Injury.- 5. Arterial Surface Changes Examined by Scanning (SEM) and Transmission (TEM) Electron Microscopy.- 15 - Surgical Techniques - Investigation and Treatment.- 1. The Investigation of Cerebral Perfusion Using Intra-Arterial Injection of Isotopically Labelled Albumin Macro-Aggregates.- 2. Extracranial to Intracranial Microvascular Anastomosis: A New Approach to the Treatment of Cerebrovascular Disease.- 3. The Surgical Repair of Acute Ventricular Septal Defect as a Complication of Myocardial Infarction.- 4. The Membrane Lung in Routine Bloodless Open Heart Surgery.- 5. New Surgical Approach to Diffuse Coronary Occlusion: Selective Arterialization of the Coronary Veins.- E. Section III (Workshop Sessions) - Chapter 1 - Lipid Clinic 1 (Objectives, Organization, Biochemical and Dietary Methods).- 1. Introduction to Lipid Clinic I.- 2. Objectives.- 3. Organization of Lipid Clinics.- 4. Standardization of Currently Employed Biochemical Procedures.- 5. The Dietary Management of Hyperlipoproteinemia.- 6. A Point of View on the Dietary Management of Hyperlipidemia.- 7. Discussion.- 2 - New Therapeutic Approaches to Acute Myocardial Infarction (MI) and its Size.- 1. Lessons from the Myocardial Infarction Research Units.- 2. The Effect of Local Vasodilating Agents.- 3. Infarct Size: Its Estimation and Modification.- 4. Mechanical Assist in the Treatment of Impending or Established Myocardial Infarction and Cardiogenic Shock.- 5. New Therapeutic Approaches to Acute Myocardial Infarction (MI) and its Size: The Surgical Approach.- 6. Discussion.- 3 - Fate of Lipoproteins.- 1. The Origin and Fate of Chylomicrons and VLDL.- 2. The Origin and Fate of LDL.- 3. The Origin and Fate of HDL.- 4. The Role of LCAT in Cholesterol Transport.- 4 - Regression of Lesions.- 1. Introduction.- 2. Progression and Regression of Experimental Atherosclerotic Lesions.- 3. Dietary Restriction and Progress of Atheroma.- 4. Regression of Complicated Atherosclerotic Lesions in the Abdominal Aortas of Swine.- 5. Studies of Regression/Progression of Atherosclerosis in Man.- 6. Approaches to Evaluating Regression of Experimental Atherosclerosis.- 7. Discussion.- 5 - Lipid Clinic II (Drugs, Genetics and Lipoprotein Dynamics).- 1. Experimental Investigation of Hypolipidemic and Anti-Atherosclerotic Drugs with Different Mechanism of Action.- 2. Treatment of Hyperlipoproteinemias with Neomycin, Probucol and Tibric Acid.- 3. Cholesterol Turnover and Metabolism in Normal and Hyperlipidemic Patients.- 4. Genetic Studies in Outpatients: Plasma Cholesterol in Family and Twin Studies.- 5. Discussion.- 6 - Atherosclerosis and Childhood.- 1. Epidemiology and Risk Factors in Childhood.- 2. The Lesion in Children.- 3. Genetics of the Hyperlipidemias and Cardiovascular Implications.- 4. Dietary Management of Familial Type II - Hyperlipoproteinemia in Children and Adolescents - A Feasibility Study.- 5. Treatment of Hyperlipidemias in Childhood.- 6. Discussion.- 7 - Plasma Lipids and Thrombosis.- 1. Introduction.- 2. Fibrinolytic Activity and Risk Factors for Atherosclerosis.- 3. Dietary Fatty Acids and Arterial Thrombosis: Effects and Mechanism of Action with Special Reference to Linoleic Acid.- 4. Uptake of Labelled Cholesterol by Organizing Thrombus.- 5. Mural Thrombosis and Plaque Growth.- 6. Dynamics of Thrombus Formation.- 7. Summary.- 8. Opening Remarks to Discussion.- 8 - Animal Models in the Study of Atherosclerosis.- 1. Genetic Studies of Atherosclerosis in Animals.- 2. The Baboon as an Experimental Model in Drug Testing.- 3. Advanced Coronary Atherosclerosis in Swine Produced by Combination of Balloon-Catheter Injury and Cholesterol Feeding.- 4. Evolution and Regression of Aortic Fatty Streaks in Rhesus Monkeys.- 5. Comparison of Primates and Rabbits as Animal Models in Experimental Atherosclerosis.- 6. Discussion.- 9 - Lipid Clinic III (The Effects of Nutrition and Treatment on Lipid Metabolism).- 1. The Effects of Nutrition on Lipid Metabolism.- 2. Influence of Dietary Fat and Protein on Plasma Cholesterol Levels in the Early Postnatal Period.- 3. Results of Treatment of Hyperlipidemias; Short Term Effect on Cholesterol Metabolism.- 4. Results of Treatment of Hyperlipidemias: Long-Term Compliance and Effect on Lipid Metabolism.- 5. The Drug Treatment of Hyperlipidemia.- 6. Discussion.- 10 - Current Investigations in Myocardial Perfusion.- 1. An Overview of Myocardial Blood Flow.- 2. Studies of Regional Myocardial Perfusion in the Anginal Patient.- 3. The Determinants of Regional Myocardial Blood Flow.- 4. Regional Myocardial Perfusion: Studies with 133Xenon and a Multiple-Crystal Scintillation Camera.- 5. Discussion.- 11 - Tissue Culture I.- 1. Tissue Culture in the Study of Atherosclerosis.- 2. Electron Microscopic Techniques in the Study of Cultured Vascular Cells.- 3. Techniques for Culturing Arterial Endothelial Cells.- 4. Cultured Human Fibroblasts in the Study of Atherosclerosis.- 5. Cultured Human Endothelial Cells in Atherosclerosis.- 6. Discussion.- 12 - Connective Tissues in Atherosclerotic Lesions.- 1. Introduction.- 2. Secretion and Assembly of Collagen - Present Status.- 3. Aortic Protocollagen Proline Hydroxylase.- 4. Pathophysiology of the Intercellular Matrix as a Whole.- 5. Morphology of Collagen and Elastin Fibers in Atherosclerotic Lesions.- 6. Biochemistry of Collagen and Elastic Fibers in Atherosclerotic Lesions.- 7. Glycosaminoglycans in Atherosclerotic Lesions.- 8. The Mode of Calcification in Atherosclerotic Lesions.- 9. Role of Arterial Lipoproteins in the Formation of Fibrous Plaque.- 10. Discussion.- 13 - Recommendations to the Public for Prevention of Atherosclerosis.- 1. Choice of Objectives in Atherosclerosis Prevention.- 2. National Views: Australia.- 3. Prevention Programs in Canada.- 4. Diet and Coronary Heart Disease - A British Point of View.- 5. New Zealand Perspectives.- 6. The Status in Sweden.- 7. The Alternative American Diet.- 8. Recommendations to the Public for Prevention of Atherosclerosis from Six Western Countries - Their Application to Children.- 9. Practical Considerations Regarding Availability of Food Supplies.- 10. Discussion.- 14 - Biochemistry of Arterial Wall; Factors in Mural Lipid Accumulation.- 1. Introduction.- 2. Effect of Lipid Accumulation on Arterial Wall Bioenergetics.- 3. Quantitative Studies of the Interaction between Plasma and Tissue Components in Human Intima.- 4. Arterial Cholesterol Esterase.- 5. Participation of Phospholipids in Arterial Metabolism of Cholesterol Esters.- 6. The Significance of 'Bound' and 'Labile' Fractions of Low-Density Lipoprotein and Fibrinogen in the Arterial Wall.- 7. Summary.- 8. Discussion.- 15 - Tissue Culture II.- 1. The Lipoproteins and Arterial Smooth Muscle Cells; Uptake of VLDL, LDL, HDL.- 2. Lipoproteins and Arterial Smooth Muscle Cells: Regulation of Cellular Metabolism by Swine Lipoproteins.- 3. The Lipoproteins and Arterial Smooth Muscle Cells: Cellular Proliferation and Morphology.- 4. The Arterial Smooth Muscle Cell: Stimulation of Cholesterol Esterification by Plasma Lipoproteins.- 5. Production of Glycosaminoglycans, Collagen and Elastic Tissue by Aortic Medial Explants.- 6. Summary.- 7. Discussion.- 16 - Endothelium and Permeability.- 1. Theoretical Models for Transport of Low-Density Lipoproteins in the Arterial Wall.- 2. The Morphologic Basis of Arterial Endothelial Permeability; Some Ultrastructural Aspects of the Evans Blue Model.- 3. Light Microscopic Localization of Actomyosin and Tropomyosin in Tissues by Immunoperoxidase Technique Following Fixation in Dimethylsuberimidate and Embedding in Polyethylene Glycol.- 4. The Morphologic Basis for Normal Endothelial Permeability; Intercellular Pathways.- 5. The Morphological Basis for Altered Endothelial Permeability in Atherosclerosis.- 6. The Influence of Hypercholesterolemia Upon Endothelial Glycocalix.- Resume of Workshop - Conference.- F. Resume of Workshop - Conference.- Closing Remarks.- G. Closing Remarks.- List and Addresses of Invited Participants.- List of Contributors.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: December, 2012
Pages: None
Weight: 1785g
Availability: Available
Subcategories: Cardiovascular Medicine, Haematology
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