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MORE ABOUT THIS BOOK
Main description:
This volume covers the entire spectrum of research on troponin and related muscle proteins, including pathophysiological and clinical aspects. It details recent advances in work on the genetic disorders of cardiac troponin and ryanodine receptor proteins. Many color figures illustrate the three-dimensional structures of the proteins involved in the muscle functions. The book will help readers understand characteristic features of the regulatory mechanisms of striated muscle contraction and their disorders at the molecular level.
Contents:
Preface Letters from A. Weber and S.V. Perry Part 1: Historical aspects.-Biological actions of calcium.- Professor Ebashi's Journey Toward the Discovery of Troponin: A Personal Recollection.- Highlights of the history of the calcium regulation of striated muscle.- Part 2: Regulation by troponin and tropomyosin.- Troponin :structure,function and dysfunction.- From crystal structure of troponin to mechanism of calcium regulation of muscle contraction.- Ca ion and troponin switch.- Disposition and dynamics: Interdomain orientations in troponin.- Structural basis for calcium-regulated relaxation of striated muscles at interaction sites of troponin with actin.- Tropomyosin: A regulator of F-actin filament.- Tropomyosin and troponin cooperativity on the thin filament.- Conformational changes in reconstituted skeletal muscle thin filaments observed by fluorescence.- Calcium structural transition of troponin in the complex, on the thin filament, and in muscle fibers, as studied by site-directed spin-labelling EPR.- Crystal structure of tropomyosin: a flexible coiled-coil.- C. elegans model for studying tropomyosin and troponin regulations of muscle contraction and animal behaviour.- Structural and functional analysis of troponin from scallop striated and human cardiac muscles.- Part 3: Regulation in cardiac muscle and disorders.- Cooperativity in the regulation of force and the kinetics of force development in heart and skeletal muscles; Cross activation of force.- Heart failure, ischemia/reperfusion injury and cardiac troponin.- Troponin mutations in cardiomyopathies.- Molecular pathogenic mechanisms of cardiomyopathies caused by mutations in cardiac troponin T.- Cardiac troponin levels as a preferable biomarker for myocardial cell degradation in clinical practice.- Part 4: Regulation by myosin.- How calcium regulates some myosins: past and present.- Calcium inhibition of physarum myosin as examined by the recombinant heavy mero-myosin.- Part 5:Excitation-contraction coupling and disorder.- Calcium-induced release of calcium from the sarcoplasmic reticulum.- Dysregulation of the gain of CICR through ryanodine receptor1 (RyR1)- The putative mechanism underlying malignent hyperthermia.- Ion pumping by calcium ATPase of sarcoplasmic reticulum.- Regulation of cell functions by Ca2+-oscillation.- Part 6: Molecular mechanisms of muscle contraction.- Evidence about the structural behaviour of myosin crossbridges during muscle contraction.- Structural alterations of thin actin filaments in muscle contraction by synchrotron X-ray fiber diffraction.- Regulation of muscle contraction by Ca2+ and ADP: Focusing on the auto-oscillation (SPOC).- A mechanism for the muscle contraction based on actin filament rotation.- On the walking mechanism of linear molecular motors.- Modeling of the F-actin structure.- Contributors.- Subject index.
PRODUCT DETAILS
Publisher: Springer (Springer Verlag, Japan)
Publication date: January, 2007
Pages: 420
Weight: 1099g
Availability: Available
Subcategories: Biochemistry, Biomechanics, Physiology
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